Inhibitory circuitry involving Y cells and Y retinal terminals in the C laminae of the cat dorsal lateral geniculate nucleus

Dankowski, Aygul; Bickford, Martha E.

doi:10.1002/cne.10640

Cited by 18 publications

(16 citation statements)

References 81 publications

(191 reference statements)

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“…Intrageniculate inhibition clearly plays an important role in receptive-field construction within dLGN, although it is unlikely that it could explain the differences in response latency and receptive-field size of Y A and Y C cells (Table 2). Although the intrageniculate inhibitory circuitry is known to differ between layer A and layer C, it is thought to be similar for Y A and Y C cells (Dankowski and Bickford 2003;Datskovskaia et al 2001). Moreover, although systematic differences in intrageniculate inhibition would make Y A and Y C cells different in the strength of their receptive-field surrounds, response gains, offsets, and mean firing rates (Bonin et al 2005), none of these differences was revealed by our measurements (Figs.…”

Section: Neuronal Mechanisms Underlying Y a -Y C Receptive-field Mismmentioning

confidence: 49%

Functional Consequences of Neuronal Divergence Within the Retinogeniculate Pathway

Yeh¹,

Stoelzel²,

Weng³

et al. 2009

Journal of Neurophysiology

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Yeh C-I, Stoelzel CR, Weng C, Alonso J-M. Functional consequences of neuronal divergence within the retinogeniculate pathway. J Neurophysiol 101: 2166 -2185, 2009. First published January 28, 2009 doi:10.1152/jn.91088.2008. The neuronal connections from the retina to the dorsal lateral geniculate nucleus (dLGN) are characterized by a high specificity. Each retinal ganglion cell diverges to connect to a small group of geniculate cells and each geniculate cell receives input from a small number of retinal ganglion cells. Consistent with the high specificity of the connections, geniculate cells sharing input from the same retinal afferent are thought to have very similar receptive fields. However, the magnitude of the receptive-field mismatches, which has not been systematically measured across the different cell types in dLGN, seems to be in contradiction with the functional anatomy of the Y visual pathway: Y retinal afferents in the cat diverge into two geniculate layers (A and C) that have Y geniculate cells (Y A and Y C ) with different receptive-field sizes, response latencies, nonlinearity of spatial summation, and contrast sensitivity. To better understand the functional consequences of retinogeniculate divergence, we recorded from pairs of geniculate cells that shared input from a common retinal afferent across layers and within the same layer in dLGN. We found that nearly all cell pairs that shared retinal input across layers had Y-type receptive fields of the same sign (i.e., both on-center) that overlapped by Ͼ70%, but frequently differed in size and response latency. The receptive-field mismatches were relatively small in value (receptive-field size ratio Ͻ5; difference in peak response Ͻ5 ms), but were robustly correlated with the strength of the synchronous firing generated by the shared retinal connections (R 2 ϭ 0.75). On average, the percentage of geniculate spikes that could be attributed to shared retinal inputs was about 10% for all cell-pair combinations studied. These results are used to provide new estimates of retinogeniculate divergence for different cell classes.

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Section: Neuronal Mechanisms Underlying Y a -Y C Receptive-field Mismmentioning

confidence: 49%

Functional Consequences of Neuronal Divergence Within the Retinogeniculate Pathway

Yeh¹,

Stoelzel²,

Weng³

et al. 2009

Journal of Neurophysiology

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“…Y cells are located in the C m , and the dendrites of A laminae Y cells cross laminar borders, whereas the dendrites of X cells are confined to the lamina of origin (Friedlander et al, 1981;Stanford et al, 1983;Wilson et al, 1984). Although the triadic arrangements of RLD profiles might imply an association with X cells (which have been suggested to be the primary target of interneurons; Sherman and Friedlander, 1988), we have found that Y retinogeniculate axons contact interneurons and that glomeruli are particularly prominent in the C m , where X cells are absent (Datskovskaia et al, 2001;Dankowski and Bickford, 2003). Thus, RLD profiles could primarily participate in circuitry involving Y cells.…”

Section: Distribution Of Rld Profiles In the Dlgnmentioning

confidence: 83%

“…In cat tissue, this antibody has been shown to stain axon thalamic terminals originating from the basal forebrain, thalamic reticular nucleus (TRN)/PGN, and pretectum (Bickford et al, 1994;Wang et al, 2001Wang et al, , 2002a as well as the dendritic terminals of dLGN interneurons Datskovskaia et al, 2001;Dankowski and Bickford, 2003).…”

Section: Antibody Characterizationmentioning

confidence: 99%

Synaptic organization of thalamocortical axon collaterals in the perigeniculate nucleus and dorsal lateral geniculate nucleus

Bickford

Wei

Eisenback

et al. 2008

J of Comparative Neurology

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We examined the synaptic targets of large non-gamma-aminobutyric acid (GABA)-ergic profiles that contain round vesicles and dark mitochondria (RLD profiles) in the perigeniculate nucleus (PGN) and the dorsal lateral geniculate nucleus (dLGN). RLD profiles can provisionally be identified as the collaterals of thalamocortical axons, because their ultrastrucure is distinct from all other previously described dLGN inputs. We also found that RLD profiles are larger than cholinergic terminals and contain the type 2 vesicular glutamate transporter. RLD profiles are distributed throughout the PGN and are concentrated within the interlaminar zones (IZs) of the dLGN, regions distinguished by dense binding of Wisteria floribunda agglutinin (WFA). To determine the synaptic targets of thalamocortical axon collaterals, we examined RLD profiles in the PGN and dLGN in tissue stained for GABA. For the PGN, we found that all RLD profiles make synaptic contacts with GABAergic PGN somata, dendrites, and spines. In the dLGN, RLD profiles primarily synapse with GABAergic dendrites that contain vesicles (F2 profiles) and non-GABAergic dendrites in glomerular arrangements that include triads. Occasional synapses on GABAergic somata and proximal dendrites were also observed in the dLGN. These results suggest that correlated dLGN activity may be enhanced via direct synaptic contacts between thalamocortical cells, whereas noncorrelated activity (such as that occurring during binocular rivalry) could be suppressed via thalamocortical collateral input to PGN cells and dLGN interneurons.

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“…In the cat's dLGN, intemeurons were thought to be mostly associated with the X pathway (Sherman and Friedlander, 1988). However, subsequent studies showed that nearly half of the synaptic targets of Y retinogeniculate terminals are intemeurons, and intemeurons contact the dendrites of Y relay cells (Datskovskaia et aI., 2001;Dankowski and Bickford, 2003). All intemeurons are GABAergic, and their outputs inhibit postsynaptic targets (Montero, 1987;Guillery et aI., 2001).…”

Section: Types Of Thalamic Cellsmentioning

confidence: 99%

Signal processing in the tectothalamic pathway.

Wei¹

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Inhibitory circuitry involving Y cells and Y retinal terminals in the C laminae of the cat dorsal lateral geniculate nucleus

Cited by 18 publications

References 81 publications

Functional Consequences of Neuronal Divergence Within the Retinogeniculate Pathway

Functional Consequences of Neuronal Divergence Within the Retinogeniculate Pathway

Synaptic organization of thalamocortical axon collaterals in the perigeniculate nucleus and dorsal lateral geniculate nucleus

Signal processing in the tectothalamic pathway.

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