2023
DOI: 10.1002/brb3.3275
|View full text |Cite
|
Sign up to set email alerts
|

Inhibitory effect and mechanism of Rosiglitazone on M1 type polarization of central microglia in intracerebral hemorrhage mice based on JNK/STAT3 signaling pathway

Chenglei Chao,
Yinghui Li,
Quan Li
et al.

Abstract: BackgroundIntracerebral hemorrhage (ICH) seriously threatens the health of people. In addition, microglia M1 polarization was confirmed to be involved in the progression of ICH. Rosiglitazone was able to be used as an antidiabetic agent, which could activate PPAR‐γ, and PPAR‐γ was reported to inhibit inflammation in microglia. However, the detailed function of Rosiglitazone in ICH remains unclear.MethodsIn vivo and in vitro experiments were used to test the function of Rosiglitazone in ICH. In addition, RT‐qPC… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 46 publications
0
2
0
Order By: Relevance
“…According to the evaluation of SYRCLE’s ROB tool, among the 26 animal experimental studies included, 6 described random sequence generation ( Zhou et al, 2012 ; Caliaperumal et al, 2014 ; Hu et al, 2019a ; Li et al, 2019 ; Cui et al, 2020 ; Ye et al, 2023 ). Only 6 studies reported incomplete data on baseline characteristics ( Gong et al, 2005 ; Xue et al, 2006 ; Zhou et al, 2011 ; Zhou et al, 2012 ; Wan et al, 2016 ; Chao et al, 2023 ), and all the remaining studies comprehensively reported baseline characteristics of the animals, including animal breed, age, weight, and sex. No studies reported information on allocation concealment and blinding of animal interventions by investigators or animal breeders.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…According to the evaluation of SYRCLE’s ROB tool, among the 26 animal experimental studies included, 6 described random sequence generation ( Zhou et al, 2012 ; Caliaperumal et al, 2014 ; Hu et al, 2019a ; Li et al, 2019 ; Cui et al, 2020 ; Ye et al, 2023 ). Only 6 studies reported incomplete data on baseline characteristics ( Gong et al, 2005 ; Xue et al, 2006 ; Zhou et al, 2011 ; Zhou et al, 2012 ; Wan et al, 2016 ; Chao et al, 2023 ), and all the remaining studies comprehensively reported baseline characteristics of the animals, including animal breed, age, weight, and sex. No studies reported information on allocation concealment and blinding of animal interventions by investigators or animal breeders.…”
Section: Resultsmentioning
confidence: 99%
“…The involvement of thrombin in the activation and polarization of microglia/macrophages after ICH has been confirmed. The activation of PAR-1 by thrombin regulates the polarization of microglia towards the M1 phenotype ( Wan et al, 2016 ; Chao et al, 2023 ). Additionally, thrombin induces the differentiation of microglia into M1 phenotype by upregulating the expression of LncRNA TCONS_00145741 and activating the JNK MAPK pathway ( Wu et al, 2022 ).…”
Section: Resultsmentioning
confidence: 99%