Inhibitory effect and mechanism on melanogenesis from fermented herbal composition for medical or food uses

Cha, Jae-Young; Yang, Hyun‐Ju; Moon, Hyung‐In; Cho, Young-Su

doi:10.1016/j.foodres.2011.11.002

Cited by 25 publications

(21 citation statements)

References 28 publications

(24 reference statements)

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“…Fermented products of traditional herb extracts by fungi and bacteria also showed strong tyrosinase inhibitory activities [10,12,13,14]. Recently, our study also found that mycelial culture broth of eight traditional herbal extracts fermented with Phellinus linteus (8-HsPLCB) inhibited melanin production and tyrosinase activity, and also reduced the contents of melanogenesis-related proteins, including tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F0 melanoma cells [15]. However, the effect of 8-HsPLCB had not been determined in brown guinea pigs, whose skin serves as an excellent pigmentation model because it is similar to human skin [16].…”

Section: Introductionmentioning

confidence: 81%

“…The skin-whitening cosmetics using traditional herbs are popular with East Asian women. We have previously found that fungus-fermented traditional herbs, including Angelica gigas and Morus alba root bark, have a much greater effect in inhibiting mushroom tyrosinase activity than those extracts only due to high contents of the phenolics and flavonoids [10,15]. Recently, our study also found that mycelial culture broth of eight kinds of traditional herbal extracts fermented with Phellinus linteus (8-HsPLCB) inhibited melanin production and tyrosinase activity, and also reduced the contents of melanogenesis-related proteins, including tyrosinase and MITF, in B16F0 melanoma cells [15].…”

Section: Discussionmentioning

confidence: 99%

“…Co., Ltd. (Korea). Mycelial culture broth of the eight kinds of traditional crude herbal extracts fermented with P. linteus (previously named as 8-HsPLCB) was prepared by cultivating at 28 o C for 9 days according to a previous study [15].…”

Section: Preparation Of Mycelial Culture Broth Of Eight Phellinus Linmentioning

confidence: 99%

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Anti-Pigmentation Effects of Eight Phellinus linteus-Fermented Traditional Crude Herbal Extracts on Brown Guinea Pigs of Ultraviolet B-Induced Hyperpigmentation

Ahn

Choo

Cho

2018

Journal of Microbiology and Biotechnology

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We have previously found that mycelia culture broth of eight kinds of traditional herbal extracts fermented with (previously named as 8-HsPLCB) not only inhibited melanin and tyrosinase activity, but also reduced the contents of melanogenesis-related proteins, including tyrosinase and microphthalmia-associated transcription factor, in 3-isobutyl-1-methylxanthine-stimulated B16F0 melanoma cells. For a further study, the effect of 8-HsPLCB against skin pigmentation in brown guinea pigs with ultraviolet B (UVB)-induced hyperpigmentation was investigated. 8-HsPLCB (3%) and arbutin (2%) as positive controls were applied topically twice daily for 4 weeks to the hyperpigmented areas. 8-HsPLCB showed skin-lightening effect as effective as arbutin, one of the most widely used in whitening cosmetics. Melanin index values as the degree of pigmentation showed a significant reduction week by week post 8-HsPLCB treatment and then substantially reduced by 4 weeks. The degree of depigmentation after 4 weeks of topical application with 8-HsPLCB was 32.2% as compared with before treatment (0 week). Moreover, using Fontana-Masson staining and hematoxylin-eosin staining, 8-HsPLCB reduced melanin pigmentation in the basal layer of the epidermis and epidermal thickness changes exposed to the UV-B irradiation as compared with non-treatment and vehicle treatment. The intensity of the skin-lightening effect of 8-HsPLCB was similar to arbutin. These results suggest that the skin-lightening effect of 8-HsPLCB might be resulted from inhibition of melanin synthesis by tyrosinase in melanocytes. To conclude, 8-HsPLCB treatment showed reduction of the melanin pigment and histological changes induced by UV irradiation in brown guinea pigs.

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Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Anti-Pigmentation Effects of Eight Phellinus linteus-Fermented Traditional Crude Herbal Extracts on Brown Guinea Pigs of Ultraviolet B-Induced Hyperpigmentation

Ahn

Choo

Cho

2018

Journal of Microbiology and Biotechnology

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“…Tyrosinase is known to be a key enzyme, and is responsible for the rate-limiting step in melanin synthesis. It was demonstrated that the inhibitory effect on melanogenesis was associated with a decrease in tyrosinase activity (Cha et al, 2012;Chaabane et al, 2014). Jeong et al (2015) showed that baicalin, a component of Scutellaria baicalensis decreased melanogenesis and tyrosinase activity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fucoidan on B16 Murine Melanoma Cell Melanin Formation and Apoptosis

Wang¹,

Xu²,

Liang³

et al. 2017

Afr J Tradit Complement Altern Med

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Background：Fucoidan is a complex sulfated polysaccharide extracted from brown seaweed and has a wide variety of biological activities. It not only inhibits cancer cell growth but also inhibits tyrosinase in vitro. Therefore, it is of interest to investigate the effect of fucoidan on B16 murine melanoma cells as the findings may provide new insights into the underlying mechanism regarding the inhibition of melanin formation by fucoidan. In the present study, we aimed to investigate the anti-melanogenic effect of fucoidan and its inhibitory effect on B16 cells. Materials and Methods:The influence of fucoidan on B16 melanoma cells and cellular tyrosinase was examined. Cell viability was examined by the cell counting kit-8 assay. Cellular tyrosinase activity and melanin content were determined using spectrophotometric methods and protein expression was analyzed by immunoblotting. Morphological changes in B16 melanoma cells were examined by phase contrast microscopy and apoptosis was analyzed by flow cytometry. Results: In vitro studies were performed using cell viability analysis and showed that fucoidan significantly decreased viable cell number in a dose-response manner with an IC50 of 550 ±4.3 µg/mL. Cell morphology was altered and significant apoptosis was induced when cells were exposed to 550 µg/mL fucoidan for 48 h. Conclusion: This study provides substantial evidence to show that fucoidan inhibits B16 melanoma cell proliferation and cellular tyrosinase activity. Fucoidan may be useful in the treatment of hyperpigmentation and as a skin-whitening agent in the cosmetics industry.

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“…The extract activates phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3beta signalling pathway and suppresses the microphthalmia-associated transcription factor. Thereby, the extract exhibits the antihyperpigmentation effects [19].…”

Section: Cosmeceutical Importance Of Fpementioning

confidence: 95%

Cosmeceutical Importance of Fermented Plant Extracts: A Short Review

2018

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Personal care products, especially cosmetics, are regularly used all over the world. The used cosmetics are discharged continuously into the environment that affects the ecosystem and human well-being. The chemical and synthetic active compounds in the cosmetics cause some severe allergies and unwanted side effects to the customers. Currently, many customers are aware of the product composition, and they are stringent in product selection. So, cosmetic producers are keen to search for an alternative, and natural active principles for the development and improvisation of the cosmetic products to attain many customers. Phytochemicals are known for several pharmacological and cosmeceutical applications. Fermentation process improved the quality of the active phytochemicals and also facilitates the easy absorption of them by human system. Recently, several research groups are working on the cosmeceutical importance of fermented plant extracts (FPE), particularly on anti-ageing, anti-wrinkle, and whitening property of FPE. The current manuscript is presenting a brief on cosmeceutical importance of FPE. COSMECEUTICAL IMPORTANCE OF FERMENTED PLANT EXTRACTS: A SHORT REVIEW

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Inhibitory effect and mechanism on melanogenesis from fermented herbal composition for medical or food uses

Cited by 25 publications

References 28 publications

Anti-Pigmentation Effects of Eight Phellinus linteus-Fermented Traditional Crude Herbal Extracts on Brown Guinea Pigs of Ultraviolet B-Induced Hyperpigmentation

Anti-Pigmentation Effects of Eight Phellinus linteus-Fermented Traditional Crude Herbal Extracts on Brown Guinea Pigs of Ultraviolet B-Induced Hyperpigmentation

Effect of Fucoidan on B16 Murine Melanoma Cell Melanin Formation and Apoptosis

Cosmeceutical Importance of Fermented Plant Extracts: A Short Review

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