Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis

Abstract

Background Actinidia arguta, known as sarunashi in Japan, is a vine tree native to east-Asia, including Japan, that produces small fruit rich in anthocyanins, catechins, vitamin C, chlorophyll, beta-carotene and other polyphenols.ResultsOur study revealed the inhibitory effect of the juice of A. arguta (arguta-juice) toward the mutagenicity of food-derived carcinogens and polycyclic aromatic hydrocarbons using the Ames test, and antioxidant activity of arguta-juice as determined using a free radical scavenging assay. The formation of DNA adducts in liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) decreased significantly following administration of arguta-juice. The preventive effect of arguta-juice on the induction of inflammation of mouse ear by 12-O-tetradecanoylphorbol-13-acetate (TPA) was revealed. The anti-carcinogenic effect of a topically applied partially purified fraction of A. arguta was revealed on skin tumorigenesis in mice induced by treatment with 7,12-dimethylbenz(a)anthracene and TPA. In an effort to reveal the mechanisms for antimutagenicity of arguta-juice, effects on the enzymes that metabolize xenobiotics were examined. Combined effects comprising i) inhibition of the metabolic activation of mutagens with phase I enzymes, but ii) no prevention on the activity of phase II detoxification enzyme, UGT, were observed. We also investigated the characterization and partial purification of the antimutagenic components in A. arguta, which suggested that the components in A. arguta responsible for the antimutagenicity were water-soluble, heat-labile phenolic compounds.ConclusionsThese results suggested that components in A. arguta are attractive candidates for potential use as chemopreventive agents.

Radioprotective activity of blackcurrant extract evaluated by in vitro micronucleus and gene mutation assays in TK6 human lymphoblastoid cells

“…Recently, Nishimura et al [ 20 ] reported that Actinidia argute , known as sarunashi, has antimutagenic and antioxidant activities. Furthermore, an extract of Barbados cherry fruit containing several antioxidants such as anthocyanin, vitamins E and C, and β-carotene showed antimutagenic effects, as measured by a MN test against radioisotope iodine-131, and this antimutagenic activity was mainly associated with the capture of free radicals generated by radiation [ 21 , 22 ].…”

The Nutritional and Health Benefits of Kiwiberry (Actinidia arguta) – a Review

“…This research suggests the future potential of healthy A. arguta fruit or constituents for use in anti-tumour treatment. Nishimura et al [ 61 ] have investigated the inhibitory effect of A. arguta juice on the mutagenicity of food-derived carcinogens and polycyclic aromatic hydrocarbons. The authors suggest that the components in A. arguta responsible for the antimutagenicity are water-soluble, heat-labile phenolic compounds.…”

Comparative analysis of agrochemical, allelopathic and microbiological characteristics of the soil environment for Actinidia arguta (Siebold et Zucc.) Planch. ex Miq. cultivated in Ukraine and two provinces of China

“…Fruits, leaves, and roots of A. arguta have a high content of phenolic compounds with allelopathic effects, that can be released into the root environment by leaching, decay of plant residues or in the form of root exudates (Zuo et al, 2012;Teng et al, 2013;Nishimura et al, 2016;Park, 2017;Latocha, 2017;Almeida et al, 2018;Li et al, 2018). The most important of them are flavan-3-ols, flavonols, phenolic acids, and anthocyanins, in particular, such as quercetin and kaempherol derivatives, as well as hydroxycinnamic acid derivatives, gallic, caffeic, chlorogenic, 2, 4-dihydroxybenzoic acids, catechin, epicatechin and rutin (Latocha, 2017;Almeida et al, 2018).…”

“…Actinidia arguta is mainly cultivated as a fruit and honey plant because it has beneficial nutritional qualities due to the high content of vitamins and mineral elements, as well as dietary properties (Park, 2017;Latocha, 2017;Pinto & Vilela, 2018;Almeida et al, 2018). Wide range of bioactive compounds with antiproliferative (Zuo et al, 2012;Latocha, 2017), antioxidant (Zuo et al, 2012Mikami-Konishide et al, 2013;Latocha, 2017;Almeida et al, 2018), antimicrobial (Almeida et al, 2018), hepatoprotective (Jho et al, 2011), antiallergic (Latocha, 2017), antiinflammatory and antinociceptive (Teng et al, 2013), antiamnesic (На et al, 2015) and some other effects (Nishimura et al, 2016;Latocha, 2017) makes hardy kiwifruit the high-value medicinal plant.…”