Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose

Shim, Youngseon; Doo, Ho Kyung; Ahn, Se Young; Kim, Yong Suk; Seong, Je Kyung; Park, In Sun; Min, Bon Hong

doi:10.1016/s0378-8741(02)00370-7

Cited by 219 publications

(138 citation statements)

References 16 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…The reaction mixture was incubated at 37℃ for 3 min, and the reaction was terminated by the addition of 200 µL of 5% dinitrosalicylic acid reagent and heating at 90℃ for Inhibition of α-glucosidase α-Glucosidase from Saccharomyces cerevisiae was used for the inhibitory assay, which was performed as described by Shim et al (Shim et al, 2003) a The treatment were run in a random order. v/w ratio = solvent-to-solid ratio; Temperature = extraction temperature; Time = extraction time.…”

Section: Evaluation Of Anti-hyperglycemic Activity In Vitromentioning

confidence: 99%

Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from <i>Psidium guajava</i> Leaf

Liu

Wang

Huang³

et al. 2015

FSTR

View full text Add to dashboard Cite

The present study evaluated the optimal parameters for Psidium guajava leaf extraction by ultrasound to obtain maximal anti-hyperglycemic activities in the extract. The response surface methodology was employed for empirical model building. The maximum inhibition of the two starch-digesting enzymes α-amylase and α-glucosidase was determined. The optimized extraction parameters of solvent-to-solid ratio, extraction time, and extraction temperature for obtaining the maximum inhibitory activity for 50 µg/mL extract were determined to be the following: 12.07 (v/w), 5.22 min, and 59.77℃ for α-amylase (47.23% ± 0.76%) and 12 (v/w), 5.22 min, and 59.94℃ for α-glucosidase (59.42% ± 0.65%), respectively. The F values for the lack-of-fit were not significant ( p > 0.05) for both second-order models, indicating them to be appropriate for describing the response surface. In conclusion, our study presents the optimal conditions for ultrasound-assisted extraction of guava leaf as a potential substance for use in diabetes treatment.

show abstract

Section: Evaluation Of Anti-hyperglycemic Activity In Vitromentioning

confidence: 99%

Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from <i>Psidium guajava</i> Leaf

Liu

Wang

Huang³

et al. 2015

FSTR

View full text Add to dashboard Cite

show abstract

“…To date, many natural AGH inhibitors have been identified (Du et al, 2006; Iwai et al, 2006;Matsui et al, 2007;Matsumoto et al, 1993;shim et al, 2003), some of which possess strong antihyperglycemic effects via the inhibition of disaccaridases responsible for glucose production. Among them, a human study reported by Fujita et al (2001) has demonstrated that touchi extract shows efficient postprandial BGL control with a 40% reduction in BGL rise in diabetic subjects.…”

Section: Discussionmentioning

confidence: 99%

Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with .ALPHA.-Glucosidase Inhibitory Activity in Rats

Fujise

Terahara

Fukui³

et al. 2008

FSTR

View full text Add to dashboard Cite

To evaluate the duration of antihyperglycemic effects of 6-O-caffeoylsophorose (CS), a newly identified natural α-glucosidase inhibitor from fermented purple-sweet potato, a single oral administration of CS was given to maltose-loaded Sprague-Dawley rats. Administration of CS (200 mg/kg) 30 min or 60 min before maltose administration produced an elevation of blood glucose level by administration of 2 g/kg of maltose in rats that was significantly lower than for no administration (control). In contrast, simultaneous or pro-administration of CS with maltose eliminated the antihyperglycemic effect. CS significantly reduced rat intestinal α-glucosidase activity in all of the small intestinal mucosal regions with a maximal reduction ratio of ca. 40% up to 60 min after CS administration. Thereafter, the intestinal α-glucosidase activity tended to return to basal level. These findings suggest that the antihyperglycemic effect of CS is restricted to pre-administration within 60 min.Keywords: α-glucosidase, caffeoylsophorose, antihyperglycemic effect, diabetes *To whom correspondence should be addressed. Email: tfujise@nakamura-u.ac.jp IntroductionAnthocyanins, one of the families of polyphenol compounds found in fruits and plants, are valued for their beneficial health effects. Pharmacologically, anthocyanins are reputed to be antimutagenic (Yoshimoto et al., 2001) and to have antioxidative effects (Oki et al., 2002). Crude anthocyanin extract of Ipomoea batatas cv Ayamurasaki has also been demonstrated to have considerable antihyperglycemic effect in Sprague Dawley (SD) rats (Matsui et al., 2002). In our previous reports, (Matsui et al., 2001a;Matsui et al., 2001b;Matsui et al., 2002) the main compounds showing antihyperglycemic effects in the extract were found to be acylated anthocyanins, both of which possess α-glucosidase (AGH, EC 3.3.1.20) inhibitory activity: YGM-3 (Cyanidin; 3-O-(2-O-(6-O-E-feruloyl-β-D-glucopyranosyl)-6-O-Ecaffeoyl-β-D-glucopyranoside)-5-O-β-D-gluconopyranoside) and YGM-6 (Peonidin; 3-O-(2-O-(6-O-E-feruloyl-β-D-glucopyranosyl) -6-O-E-caffeoyl-β-D-glucopyranoside)-5-O-β-D-gluconopyranoside).Further study regarding the structure-AGH inhibition relationship revealed that the acylated moieties (e.g., 6-O-E-caffeoyl-β-D-glucopyranoside) were responsible for eliciting AGH inhibition (Matsui et al., 2001b; Terahara et al., 2003). 6-O-Caffeoylsophorose (CS), which is a constituent of YGM-3 and YGM-6, was successfully produced by fermentation of purple-fleshed sweet potato and was identified for the first time as a natural compound and proven to be a potent AGH inhibitor Terahara et al., 2003).Recently, AGH inhibitors have attracted much attention as being effective drugs for noninsulin-dependent diabetes mellitus (NIDDM), as they can suppress or delay excessive postprandial elevation of blood glucose level (BGL) without promoting insulin secretion. In addition, the effective use of long-term therapeutic drug acarbose treatment in the prevention of NIDDM was reported (Chiasson et al., 2002). Clinical ...

show abstract

“…Several studies have proved that by inhibiting the enzyme action, glucose levels can be brought back to normal limits (Puls et al, 1977;Shim et al, 2003). In the study, action of honey in inhibiting the enzyme action was assessed and the results showed that more the sample concentration, more the percentage of inhibition of enzyme activity (Fig.…”

Section: Inhibition Of α-Glucosidasementioning

confidence: 97%

Antioxidant Activity, DNA and Cellular Protective Effect of Honey from Srilanka

Sherin¹,

Benny²,

Ashadevi³

2015

Asian J. of Biochemistry

View full text Add to dashboard Cite

Honey is a natural product produced by honey bees. Its value is increasing in food industry because of its nutritional and medicinal properties. Besides this, it also contains certain volatile chemicals, phenolic acids, flavonoids and carotenoid like substances which play a major role in antioxidant properties. The composition of honey depends on the plant species visited by the honeybees. The present study was carried out to evaluate the antioxidant activity of Srilankan honey and its role in protecting DNA and erythrocytes from free radical induced oxidative damage. Total phenolic, flavonoid and proanthocyanidin content present in honey was measured, in addition antioxidant assays like 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, reducing power, β-carotene linoleic acid assay, α-glucosidase enzyme inhibition assay, superoxide anion radical scavenging activity and ability of chelating ferrous ions were also studied.

show abstract

Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose

Cited by 219 publications

References 16 publications

Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from <i>Psidium guajava</i> Leaf

Optimization Extraction Conditions with Ultrasound for Anti-hyperglycemic Activities from <i>Psidium guajava</i> Leaf

Durable Antihyperglycemic Effect of 6-O-Caffeoylsophorose with .ALPHA.-Glucosidase Inhibitory Activity in Rats

Antioxidant Activity, DNA and Cellular Protective Effect of Honey from Srilanka

Contact Info

Product

Resources

About