Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration

Nishimura, Erica; Fukuda, Kazumasa; Matsuda, Satoru; Kobayashi, Ryota; Matsui, Kazuaki; Takeuchi, Masashi; Okubo, Koshu; Hirahashi, Junichi; Nakamura, Rieko; Kawakubo, Hirofumi; Kitagawa, Yuko

doi:10.1007/s00595-022-02637-x

Cited by 1 publication

(2 citation statements)

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“…Institutional and national guidelines for the care and use of laboratory animals were followed. Mouse pneumonia model was induced as reported in [11] . 1 × 10 6 H22 cells in 100 μL PBS were injected into the tail vein, and immediately thereafter, 20 μg of LPS in 50 μ L PBS were intra-nasally administered.…”

Section: Methodsmentioning

confidence: 99%

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Pneumonia promotes pulmonary metastasis of HCC after transplantation via VEGF regulated PI3K/AKT/Cas-9 signaling and angiogenesis

Zhuang,

Lu,

Zhuo

et al. 2024

Hepatoma Res

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Aim: Pneumonia is the most frequent early postoperative complication in liver transplantation (LT) recipients. Inflammation may provide a favorable environment for tumor implantation, so we aimed to evaluate the impact of pneumonia on pulmonary metastasis of hepatocellular carcinoma (HCC) and reveal its underlying mechanism. Methods: A training cohort with 234 LT recipients were recorded and analyzed. Using the propensity-score method, we matched covariates between patients with and without pneumonia. A model for predicting pulmonary metastasis was built and validated in an independent validating cohort containing 179 subjects. A mouse model was built to mimic HCC pulmonary metastasis. The potential pathway was revealed by cytokine array analysis and validated in vitro . Results: Pneumonia was an independent risk factor for pulmonary metastasis in liver transplant recipients. It promoted pulmonary metastasis in both the clinical setting and the mouse model. In vitro , LPS-stimulated VEGF secretion from macrophages in the lung significantly reduced cell apoptosis and activated PI3K/AKT/cas-9 signaling. Administration of VEGF receptor2 inhibitor Vatalanib could reduce metastasis and improve prognosis in pneumonia mice. Conclusion: Pneumonia promotes HCC pulmonary metastasis by activating PI3K/AKT/Cas-9 signaling in HCC cells via macrophage-originated VEGF. Vatalanib might be efficient in reducing HCC pulmonary metastasis in liver transplant recipients with pneumonia.

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Section: Methodsmentioning

confidence: 99%

“…Recently, the impact of inflammation on cancer metastasis has received increasing attention. Previous studies showed that lung inflammation promoted pulmonary metastasis of several types of tumors [11][12][13][14] . Inflammation-induced lung metastasis could be attenuated by aspirin or antibiotics [12,15] .…”

Section: Introductionmentioning

confidence: 97%