Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases

Akamatsu, Hirohiko; Komura, Jinro; Asada, Yasuo; Niwa, Yukie

doi:10.1007/bf00372056

Cited by 111 publications

(59 citation statements)

References 38 publications

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“…Naturally occurring azelaic acids possess comedolytic activity [54], anti-bacterial properties against P. acnes [55] including the normalization of keratinization [56] and anti-inflammatory effects on neutrophil function [57] as well as skin-lightening properties [58]. In addition to a single treatment with azelaic acid, combination treatments with other anti-acne agents, particularly benzoyl peroxide, enhanced efficacy [59].…”

Section: Azelaic Acidmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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SynopsisAcne vulgaris suppresses an individual's self-confidence by causing distress with regard to physical appearance, which affects a significant number of individuals during puberty and is delineated by adolescence. Several treatments have been introduced to decrease the aesthetic and psychological problems caused by acne. The topical application of therapeutic agents has been found to be more feasible than hormonal treatment and laser therapy. The ingredients in topical acne treatments, particularly herbs and naturally derived compounds, have received considerable interest as they have fewer adverse effects than synthetic agents. Ré suméL'acné vulgaire touche à l'assurance d'un individu en causant une détresse face à son apparence physique. Elle affecte un nombre important d'individus pendant la puberté et est associée à l'adolescence. Plusieurs traitements ont été proposés pour diminuer les problèmes esthétiques et psychologiques causés par l'acné. L'application topique d'agents thérapeutiques a été estimée plus aisée qu'un traitement hormonal et une thérapie laser. Les ingrédients des traitements topiques de l'acné, particulièrement les plantes et les composés naturels dérivés ont suscité un intérêt considérable par leurs moindres effets indésirables que les ingrédients synthé-tiques.

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Section: Azelaic Acidmentioning

confidence: 99%

Therapeutic agents and herbs in topical application for acne treatment

Kanlayavattanakul

Lourith

2011

Intern J of Cosmetic Sci

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“…This might account for the unusually high calcification associated with lipid core domains. Second, azelaic acid has been noted to have anti-inflammatory properties and has been noted to decrease cytokine production by macrophages and inflammatory cells [223][224][225]. It also has been noted to reduce oxidant production by leukocytes [223].…”

Section: Azelaic Acid a Lipid Peroxidation-derived Lipophilic Dicarbmentioning

confidence: 99%

“…Second, azelaic acid has been noted to have anti-inflammatory properties and has been noted to decrease cytokine production by macrophages and inflammatory cells [223][224][225]. It also has been noted to reduce oxidant production by leukocytes [223]. Thus, it has been added as an active ingredient in topical skin medications, particularly as anti-acne agent [224][225][226].…”

Section: Azelaic Acid a Lipid Peroxidation-derived Lipophilic Dicarbmentioning

confidence: 99%

Lipid peroxidation and decomposition — Conflicting roles in plaque vulnerability and stability

Parthasarathy

Litvinov

Selvarajan

et al. 2008

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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The low density lipoprotein (LDL) oxidation hypothesis has generated considerable interest in oxidative stress and how it might affect atherosclerosis. However, the failure of antioxidants, particularly vitamin E, to affect the progression of the disease in humans has convinced even staunch supporters of the hypothesis to take a step backwards and reconsider alternatives.Preponderant evidence for the hypothesis came from animal antioxidant intervention studies. In this review we point out basic differences between animal and human atherosclerosis development and suggest that human disease starts where animal studies end. While initial oxidative steps in the generation of early fatty streak lesions might be common, the differences might be in the steps involved in the decomposition of peroxidized lipids into aldehydes and their further oxidation into carboxylic acids. We suggest that these steps may not be amenable to attenuation by antioxidants and antioxidants might actually counter the stabilization of plaque by preventing the formation of carboxylic acids which are anti-inflammatory in nature. The formation of such dicarboxylic acids may also be conducive to plaque stabilization by trapping calcium.We suggest that agents that would prevent the decomposition of lipid peroxides and promote the formation and removal of lipid hydroxides, such as paraoxonase (PON 1) or apo A1/high density lipoprotein (HDL) might be more conducive to plaque regression. KeywordsAtherosclerosis; aldehydes; dicarboxylation; inflammation; calcification Oxidation hypothesis of atherosclerosisAtherosclerosis is the major manifestation of cardiovascular diseases. The role of lipoproteins in atherosclerosis development has been a topic of interest for over five decades. It is now established beyond doubt that high levels of low density lipoprotein (LDL) and low levels of high density lipoprotein (HDL) contribute significantly to the development and progression of cardiovascular diseases [1][2][3][4][5].The biochemical processes that contributed to the formation of early atherosclerotic lesions, the fatty streak lesions, are still under debate. The LDL oxidation hypothesis was put forward in the eighties to explain the formation of fatty streak lesions and over 4000 publications and countless reviews have appeared on the topic to date [6][7][8][9][10][11] providing evidence for the presence *Address correspondence to: Sampath Parthasarathy, Ph.D., M.B.A*. N-850 Doan Hall, 410 W. 10 th Avenue, Ohio State University, Columbus, OH 43210, Tel: (614) Fax: (614) 292-9259, E-mail: spartha@osumc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all ...

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“…It is produced when Malassezia is grown in the presence of oleic acid and is a competitive inhibitor of tyrosinase, an enzyme involved in the production of melanin (302). In addition to having antibacterial (190,242) and antifungal (65) activity, azelaic acid inhibits the proliferation of several tumor cell lines (331) and decreases the production of reactive oxygen species in neutrophils by inhibiting cell metabolism (9).…”

Section: Structure Physiology and Biochemistrymentioning

confidence: 99%

Immunology of Diseases Associated withMalasseziaSpecies

2002

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SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

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Inhibitory effect of azelaic acid on neutrophil functions: a possible cause for its efficacy in treating pathogenetically unrelated diseases

Cited by 111 publications

References 38 publications

Therapeutic agents and herbs in topical application for acne treatment

Therapeutic agents and herbs in topical application for acne treatment

Lipid peroxidation and decomposition — Conflicting roles in plaque vulnerability and stability

Immunology of Diseases Associated withMalasseziaSpecies

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