Inhibitory effect of baicalin on allergic response in ovalbumin-induced allergic rhinitis guinea pigs and lipopolysaccharide-stimulated human mast cells

Zhou, Yunjiang; Wang, Hu; Sui, Hehuan; Li, Li; Zhou, Chunyun; Huang, Jiajun

doi:10.1007/s00011-016-0943-0

Cited by 40 publications

(21 citation statements)

References 29 publications

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“…In other words, one possible explanation for the anti-inflammatory effects of artemisinin might be the inhibition of MAPK pathways, which reduced the levels of inflammatory mediators. It is also well-known that MAPKs play important roles in the activation of NF-κB, which regulates a wide variety of genes involved in the allergy process [ 24 , 25 ]. Our study illustrated that artemisinin inhibited the activation of ERK, while the effect of artemisinin on the NF-κB pathway should be validated in future studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model

Wang

Luo

et al. 2018

Allergy Asthma Clin Immunol

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BackgroundAllergic rhinitis (AR), characterized by sneezing, nasal itching and rhinorrhea, affects a large number of population. This study aimed to explore the effects of artemisinin alone or combined with neurectomy of pterygoid canal in ovalbumin-induced AR mouse model and illustrate the underlying mechanisms.MethodsAllergic symptoms were evaluated to verify inhibitory effect of artemisinin alone or combined with neurectomy of pterygoid canal on AR. Serum levels of histamine, immunoglobulin E (IgE) and inflammatory factors TNF, INF-γ, IL-1β IL-10, IL-4 and IL-5 were measured by ELISA. The mRNA levels of TNF, INF-γ, IL-1β and IL-10 in local lymph nodes were measured by RT-qPCR. The total and phosphorylated levels of ERK and JNK were assessed by Western blot. CD4+CD25+Foxp3+ T (Treg) cells were analyzed by flow cytometry.ResultsArtemisinin significantly relieved the behavior symptoms of AR mice. The administration of artemisinin strikingly suppressed the expression of histamine, IgE and inflammatory factors. An increased Treg cell proportion and inhibited ERK phosphorylation were observed in artemisinin-treated groups as compared to those in the AR group. Moreover, artemisinin plus neurectomy of pterygoid almost abolished the behavioral score increase in AR mice.ConclusionsThese results indicated that artemisinin exhibited anti-allergic effect by inhibiting ERK activation and increasing Treg cell proportion, which subsequently decreased the expressions of allergic mediators. In addition, artemisinin combined with neurectomy of pterygoid showed better efficacy than artemisinin alone.Electronic supplementary materialThe online version of this article (10.1186/s13223-018-0249-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model

Wang

Luo

et al. 2018

Allergy Asthma Clin Immunol

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“…(BC) (7-D-glucuronic acid-5,6dihydroxyflavone) is a flavonoid extracted from the dried roots of Scutellaria baicalensis Georgi which has been clinically utilized as the traditional medicines and the nutritional supplements [9]. BC is known for its several pharmacological actions, including antiinflammatory and anti-allergic properties [10,11]. Studies using several cell lines and animal models have reported BC or herbal extracts rich in BC to possess anti-proliferative or anti-tumor effects [12][13][14].…”

Section: Baicalinmentioning

confidence: 99%

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Jin

2020

Aging

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BPH is a disease prevalent among elderly men that is characterized by abnormal proliferation of prostatic epithelial and stromal tissues. No effective treatment exists for BPH owing to lack of a clear understanding of its molecular etiology. Although several studies have reported therapeutic effects of baicalin against numerous diseases, including prostate cancer, its beneficial effects on BPH have not yet been explored. The present study investigated the therapeutic effects of baicalin on the development of BPH and its mechanism of action. We established a testosterone-treated BPH animal model and DHT-stimulated prostate cell lines, including RWPE-1 and WPMY-1. Administration of baicalin ameliorated the pathological prostate enlargement, suppressed the production of DHT, and inhibited the activity of 5α-reductase Type II in the animal model. BC exerted these effects via its anti-proliferative effects by restoring the Bax/Bcl-2 ratio, activating caspase-3 and caspase-8, and inducing the phosphorylation of AMPK. In vitro studies using DHT-stimulated prostate cells demonstrated an up-regulation of BPH-related and proliferation markers, whereas baicalin clearly reduced the overexpression of AR, PSA, PCNA, and Bcl-2. These results suggested that baicalin could suppress androgen-dependent development of BPH both in vivo and in vitro by inducing apoptosis.

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“…Allergic rhinitis (AR) is a type of chronic inflammation in the respiratory tract [1]. It is a very common disease of nasal mucosa, triggered by the interaction of specific immunoglobulin E (IgE) and ubiquitous environmental proteins in sensitized patients [2]. The main symptoms of AR are sneezing, rhinorrhea, itching and nasal congestion; these symptoms are usually accompanied by other related symptoms such as nasal mucosa swelling [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the use of natural products for treating AR has been increasing worldwide; many prior trials have evaluated the effectiveness of herbal medicines for AR [10]. Baicalin, a flavonoid compound isolated from Scutellaria baicalensis Georgi, has been shown to have multiple pharmacological activities, including anti-allergic, anti-inflammatory and antioxidant effects [2]. Based on its anti-allergic and anti-inflammatory activity, baicalin is widely used to treat various allergic and inflammatory diseases, including asthma, atopic dermatitis and AR [11].…”

Section: Introductionmentioning

confidence: 99%

Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats

Chen

Shu

et al. 2019

R. Soc. open sci.

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Allergic rhinitis (AR) is a global health problem that appears in all age groups and affects approximately 15–30% of people. Baicalin has been used for the treatment of various allergic diseases, including AR. However, the metabolic mechanisms of AR and baicalin against AR have not been systematically studied. Here, ovalbumin-sensitized AR rats were used as a model, and animal behaviour, histological analysis, enzyme-linked immunosorbent assay (ELISA) and metabolomics were used to elucidate the mechanism of baicalin for AR. The results indicated that baicalin has a protective effect on AR rats by inhibiting the release of immunoglobulin E (IgE), histamine, interleukin-1 beta (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). In addition, ovalbumin-induced AR included modulation of arachidonic acid, leukotriene A4 (LTA4), leukotriene B4 (LTB4), α-ketoglutaric acid, phosphatidylcholine PC (20 : 4/0 : 0), PC (16 : 0/0 : 0), citric acid, fumarate, malate, 3-methylhistidine, histamine and other amino acids that are involved in arachidonic acid, histidine metabolism, the TCA cycle and amino acid metabolism. Thus, AR could be alleviated or reversed by baicalin.

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Inhibitory effect of baicalin on allergic response in ovalbumin-induced allergic rhinitis guinea pigs and lipopolysaccharide-stimulated human mast cells

Cited by 40 publications

References 29 publications

Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model

Effect of artemisinin and neurectomy of pterygoid canal in ovalbumin-induced allergic rhinitis mouse model

Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis

Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats

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