Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway

Huang, Xiaoxue; Yi, Yuling; Yong, Jiangyan; Sun, Jiayi; Song, Zhen; Li, Dongmei; Li, Yan

doi:10.1038/s41429-021-00463-w

Cited by 15 publications

(6 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Helicobacter hepaticus could translocate from the intestine to breast tissues and promote the progression of breast cancer [ 45 ]. On the other hand, berberine is widely used as an antimicrobial drug for the treatment of diarrheal infection [ 46 , 47 ] and shows antimicrobial activities against several microorganisms, such as Helicobacter pylori , Candida albicans , and Klebsiella pneumoniae [ 48 , 49 , 50 , 51 ]. Therefore, we could speculate that berberine might play the anticancer role via inhibiting intratumoral microbes and regulating gut microbiota.…”

Section: Effects Of Berberine On Cancersmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

View full text Add to dashboard Cite

Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.

show abstract

Section: Effects Of Berberine On Cancersmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

“…In addition, the KEGG enrichment results of DEGs showed that the most obvious enrichment pathway was the MAPK pathway in the biofilm-forming phase after AMP-17 treatment. In C. albicans , the HOG-MAPK pathway regulates important physiological functions such as morphology, oxidative stress pressure, cell wall biosynthesis, and yeast-to-hyphae transition [ 34 ]. Some genes involved in the MAPK pathway (HOG1, CKE1, CCP1, CPH1, and WOR2), with AMP-17 treatment, were downregulated by 1.94-, 1.94-, 1.78-, 2.48-, and 2.06-fold, respectively, and STP4 was upregulated by 3.35-fold.…”

Section: Resultsmentioning

confidence: 99%

The Antimicrobial Peptide AMP-17 Derived from Musca domestica Inhibits Biofilm Formation and Eradicates Mature Biofilm in Candida albicans

et al. 2022

View full text Add to dashboard Cite

The biofilm formation of C. albicans represents a major virulence factor during candidiasis. Biofilm-mediated drug resistance has necessitated the search for a new antifungal treatment strategy. In our previous study, a novel antimicrobial peptide named AMP-17 derived from Musca domestica was confirmed to have significant antifungal activity and suppress hyphal growth greatly in C. albicans. In the current work, we aimed to investigate the antibiofilm property of AMP-17 in C. albicans and explore the underlying mechanism. An antifungal susceptibility assay showed that AMP-17 exerted a strong inhibitory efficacy on both biofilm formation and preformed biofilms in C. albicans. Furthermore, AMP-17 was found to block the yeast-to-hypha transition and inhibit the adhesion of biofilm cells with a reduction in cellular surface hydrophobicity. A morphological analysis revealed that AMP-17 indeed suppressed typical biofilm formation and damaged the structures of the preformed biofilm. The RNA-seq showed that the MAPK pathway, biosynthesis of antibiotics, and essential components of the cell were mainly enriched in the biofilm-forming stage, while the citrate cycle (TCA cycle), phenylamine metabolism, and propanoate metabolism were enriched after the biofilm matured. Moreover, the co-expressed DEGs in the two pairwise comparisons highlighted the terms of transmembrane transporter activity, regulation of filamentation, and biofilm formation as important roles in the antibiofilm effect of AMP-17. Additionally, qRT-PCR confirmed that the level of the genes involved in cell adhesion, filamentous growth, MAPK, biofilm matrix, and cell dispersal was correspondingly altered after AMP-17 treatment. Overall, our findings reveal the underlying antibiofilm mechanisms of AMPs in C. albicans, providing an interesting perspective for the development of effective antifungal agents with antibiofilm efficacy in Candida spp.

show abstract

“…C. albicans is susceptible to resistance to commonly used antifungal drugs such as fluconazole and amphotericin B (72). Berberine was found to inhibit fluconazole-resistant C. albicans through its action on the highosmolarity glycerol mitogen-activated protein kinase (HOG-MAPK) pathway, with increased susceptibility to fluconazole after treatment (73). The formation of C. albicans biofilm increases its drug resistance and virulence.…”

Section: Berberinementioning

confidence: 99%

The effect of herbal medicine in innate immunity to Candida albicans

Bao

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Candida albicans (C. albicans) is an opportunistic pathogenic fungus that often causes mucosal and systemic infections. Several pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), have been implicated in the host recognition of C. albicans. These PRRs recognize the pathogen-associated molecular patterns (PAMPs) of C. albicans to activate innate immune cells, thereby rapidly inducing various inflammatory responses by activating intracellular signaling cascades. Herbal medicine and its active components deserve priority development due to their low toxicity and high antibacterial, antiviral and antifungal activities. This review discussed the activities of herbal compounds against C. albicans and their related mechanisms, especially their regulatory role on innate immune cells such as neutrophils, macrophages, and dendritic cells (DCs) implicated in C. albicans infections. Our work aims to find new therapeutic drugs and targets to prevent and treat diseases caused by C. albicans infection with the mechanisms by which this fungus interacts with the innate immune response.

show abstract

Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway

Cited by 15 publications

References 44 publications

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

The Antimicrobial Peptide AMP-17 Derived from Musca domestica Inhibits Biofilm Formation and Eradicates Mature Biofilm in Candida albicans

The effect of herbal medicine in innate immunity to Candida albicans

Contact Info

Product

Resources

About