Inhibitory Effect of Caerulein on Salivary Secretion in Man

Loguercio, C.; Costato, D.; Blanco, C. Del Vecchio

doi:10.1159/000200684

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…The results by Marcinkiewicz et al [52] suggest that the interference of cerulein in the mechanisms of water secretion is short term and therefore reversible. Loguercio et al [53] argue that the reduced saliva secretion, induced by cerulein, could result from it causing contraction of the smooth muscles of the salivary ducts. However, we noticed that—in contrast to the fluid secretion—the mechanism responsible for the synthesis/secretion of proteins appears to be more sensitive to the effects induced by cerulein AP.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Defense, Oxidative Modification, and Salivary Gland Function in an Early Phase of Cerulein Pancreatitis

Maciejczyk

Skutnik-Radziszewska

Zieniewska

et al. 2019

Oxidative Medicine and Cellular Longevity

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Acute pancreatitis (AP) is a multifactorial disease characterized by necroinflammatory changes of the pancreas. Our study is the first study which evaluated the relationship between the free radical production, enzymatic and nonenzymatic antioxidants, oxidative damage, and secretory function of the salivary glands of AP rats. Male Wistar rats were divided equally into 2 groups: control (n=9) and AP (n=9). AP was induced by intraperitoneal injection with cerulein and confirmed by higher serum amylase and lipase. We have demonstrated that the superoxide dismutase and glutathione reductase activities, as well as reduced glutathione concentration, were significantly decreased in both the parotid and submandibular glands of AP rats as compared to the control rats. The production of free radicals evidenced as dichlorodihydrofluorescein assay and the activity of NADPH oxidase and xanthine oxidase and IL-1β concentration were significantly higher in the parotid and submandibular glands of AP rats compared to the controls. In AP rats, we also showed a statistical increase in oxidation modification products (advanced glycation end products and advanced oxidation protein products), salivary amylase activity, and significant decrease in the total protein content. However, we did not show apoptosis and any morphological changes in the histological examination of the salivary glands of AP rats. To sum up, cerulein-induced AP intensifies production of oxygen free radicals, impairs the redox balance of the salivary glands, and is responsible for higher oxidative damage to these glands. Interestingly, oxidative modification of proteins and dysfunction of the antioxidant barrier are more pronounced in the submandibular glands of AP rats.

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Section: Discussionmentioning

confidence: 99%