Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma

Redier, H.; Chanez, Pascal; Vos, Christine De; Rifai, N.; Clauzel, A.M.; Michel, François‐Bernard; Godard, P.

doi:10.1016/0091-6749(92)90074-c

Cited by 92 publications

(44 citation statements)

References 45 publications

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“…Rédier et al [25]showed similar data within the bronchi of asthmatics during a late–phase reaction induced by antigen provocation. These results prompted several investigators to perform different studies concerning a possible modulating effect of CTZ in experimental and clinical conditions involving adhesion molecule expression and function.…”

Section: Modulation Of Cell Trafficking and Adhesion Molecule Expressionsupporting

confidence: 55%

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Rihoux

Michel²,

Arnold³

et al. 1999

Int Arch Allergy Immunol

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Some recent clinical studies carried out with the potent H₁–antihistamine cetirizine (CTZ) suggest that this drug could be useful for the treatment of mild to moderate asthma and even for the prevention of the disease. Besides a potent antagonism of H₁–receptors at bronchial level, this drug was also shown to exert a large series of anti–inflammatory effects in in vitro, ex vivo and in vivo pharmacological models and also in clinical situations in atopic subjects. All the data collected up to now suggest the possible existence in the molecule of a central key mechanism of action on resident cells especially involved in cell trafficking and bronchial inflammation, i.e a down–regulating effect on the nuclear factor_KB (NF_KB). This hypothesis was tested on human endothelial cells and a human epithelial pulmonary cell line using different experimental methods. The results showed that CTZ down–regulates the TNF–α–induced hyperactivation of NF_KB in these two different resident cells at physiological concentrations.

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Section: Modulation Of Cell Trafficking and Adhesion Molecule Expressionsupporting

confidence: 55%

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Rihoux

Michel²,

Arnold³

et al. 1999

Int Arch Allergy Immunol

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“…Studies have shown that cetirizine exhibited, even after a single dose, an inhibitory effect on the migration of eosinophils in skin, nose, eyes and lungs after allergen challenge [16, 17, 18, 19, 20]. This potential antiallergic effect has up to now not been shown for fexofenadine at therapeutic serum concentrations and could be of use in alleviating the symptoms during the late phase of the allergic reaction which occurs 6 h after allergen exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Cetirizine is minimally metabolized [9], crosses the blood-brain barrier with difficulty [10], has a low incidence of adverse effects [11]and a low potential to cause cardiac arrhythmias [12, 13, 14, 15]. In addition, cetirizine has been shown to inhibit eosinophil recruitment in the skin, nose, eyes and lungs [16, 17, 18, 19, 20]. …”

Section: Introductionmentioning

confidence: 99%

Controlled Comparison of the Efficacy and Safety of Cetirizine 10 mg o.d. and Fexofenadine 120 mg o.d. in Reducing Symptoms of Seasonal Allergic Rhinitis

Horak

Stübner

Zieglmayer

et al. 2001

Int Arch Allergy Immunol

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Background: The efficacy, onset and duration of action and safety of cetirizine 10 mg o.d., fexofenadine 120 mg o.d., and placebo were compared in this investigator-blinded, crossover study involving the use of the Vienna Challenge Chamber. Methods: 40 volunteers with seasonal allergic rhinitis were exposed to a controlled grass pollen concentration for 6 h on 2 consecutive days. Subjective symptoms and objective measurements were recorded during the allergen exposure periods. Results: Both active medications were significantly more effective than placebo and had a comparable onset of action in alleviating the symptoms of seasonal allergic rhinitis. The efficacy of both active drugs was comparable for the first 4 h after administration of the drugs on day 1 and day 2. However from 22 to 24 h after the first dose cetirizine was significantly superior to fexofenadine for the major symptom complex score and for sneezing. Concerning the total symptom complex score at day 2 fexofenadine could not reach superiority to placebo. No serious adverse events were reported. Conclusions: Cetirizine and fexofenadine were significantly better than placebo, also in reducing the symptom of nasal congestion. However cetirizine appears to have a longer duration of action than fexofenadine.

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“…Some H 1 -antihistamines have demonstrated anti-inflammatory properties in the bronchial mucosa. Indeed, in a study of allergic untreated asthmatics who were allergeninhalation challenged, Rédier et al [45] observed lower bronchoalveolar lavage inflammatory (mainly eosinophils) cell numbers in the cetirizine versus the placebo pretreated. No significant clinical modification in the allergen inhalation-challenge test was observed.…”

Section: Pharmacotherapymentioning

confidence: 99%

Pediatric Allergic Rhinitis and Asthma: Can the March be Halted?

et al. 2013

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The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of 'united airways disease' or 'respiratory allergy', implying that allergy, in its widest sense, underlies this clinical syndrome. Progression from AR to asthma is frequent and part of the 'atopic march'. Since pediatric immune responses are more adaptable and therefore may be more amenable to treatment, interventions at early childhood are characterized by a higher chance to affect the natural history of respiratory allergy. Although current treatments are quite effective in alleviating respiratory allergy symptoms, it has proven much more difficult to confirm any influence on the progression of the disease. Much more promising is the field of specific allergen immunotherapy, where current evidence, although not yet of ideal robustness, points towards a disease-modifying effect. In addition, newer or emerging, possibly more effective or more targeted interventions are promising in the preventive sense.

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Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma

Cited by 92 publications

References 45 publications

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Hypothetical Mechanisms of Action of an H1–Antihistamine in Asthma

Controlled Comparison of the Efficacy and Safety of Cetirizine 10 mg o.d. and Fexofenadine 120 mg o.d. in Reducing Symptoms of Seasonal Allergic Rhinitis

Pediatric Allergic Rhinitis and Asthma: Can the March be Halted?

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