Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model

Arzi, Laleh; Farahi, Ali; Jafarzadeh, Nazli; Riazi, Gholamhossein; Majid, Shahana; Hoshyar, Reyhane

doi:10.1089/dna.2018.4351

Cited by 42 publications

(18 citation statements)

References 30 publications

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“…In previous studies of triple-negative breast cancer (TNBC), crocin inhibited the metastasis of lung and liver cancer cells from the breast by inhibiting Wnt/β-catenin and increased the weight, survival rate, and volume of tumors in mice. Crocin reduced metastasis, invasion, and extracellular adhesion of TNBC cells in a dose-dependent manner, and its mechanism was related to the inhibition of the downstream factors FZD7, NEDD9, VIM, and VEGF-a [35,36].…”

Section: Introductionmentioning

confidence: 96%

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Wang

et al. 2020

Neural Plasticity

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At present, most of the drugs have little effect on the pathological process of rheumatoid arthritis (RA). Analgesia is an important measure in the treatment of RA and is also one of the criteria to determine the therapeutic effects of the disease. Some studies have found that crocin, a kind of Chinese medicine, can effectively alleviate pain sensitization in pain model rats, but the mechanism is not clear. Emerging evidence indicates that crocin may inhibit the metastasis of lung and liver cancer cells from the breast by inhibiting Wnt/β-catenin and the Wnt signaling pathway is closely related to RA. Wnt5a belongs to the Wnt protein family and was previously thought to be involved only in nonclassical Wnt signaling pathways. Recent studies have shown that Wnt5a has both stimulatory and inhibitory effects on the classical Wnt signaling pathway, and so, Wnt5a has attracted increasing attention. This study demonstrated that crocin significantly increased the mechanical thresholds of adjuvant-induced arthritis (AIA) rats, suggesting that crocin can alleviate neuropathic pain. Crocin significantly decreased the levels of pain-related factors and glial activation. Foxy5, activator of Wnt5a, inhibited the above effects of crocin in AIA rats. In addition, intrathecal injection of a Wnt5a inhibitor significantly decreased hyperalgesia in AIA rats. This research shows that crocin may alleviate neuropathic pain in AIA rats by inhibiting the expression of pain-related molecules through the Wnt5a/β-catenin pathway, elucidating the mechanism by which crocin relieves neuropathic pain and provides a new way of thinking for the treatment of AIA pain.

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Section: Introductionmentioning

confidence: 96%

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Wang

et al. 2020

Neural Plasticity

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“…Several studies assigned most of the observed anti-metastatic effects of saffron to its crocin content in different types of cancers including breast, esophageal and melanoma [ 42 , 43 , 44 ]. Different molecular mechanisms of action of crocin have been described in these systems.…”

Section: Discussionmentioning

confidence: 99%

Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells

Güllü

Kobelt

Brim

et al. 2020

Cells

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The high mortality rate of colorectal cancer (CRC) patients is directly associated with metastatic dissemination. However, therapeutic options specifically for metastasis are still limited. We previously identified Metastasis-Associated in Colon Cancer 1 (MACC1) as a major causal metastasis-inducing gene. Numerous studies confirmed its value as a biomarker for metastasis risk. We investigated the inhibitory impact of saffron on MACC1-induced cancer cell growth and motility. Saffron crudes restricted the proliferation and migration of MACC1-expressing CRC cells in a concentration- and MACC1-dependent manner. Saffron delays cell cycle progression at G2/M-phase and does not induce apoptosis. Rescue experiments showed that these effects are reversible. Analysis of active saffron compounds elucidated that crocin was the main compound that reproduced total saffron crudes effects. We showed the interaction of MACC1 with the cancer stem cell (CSC) marker DCLK1, which contributes to metastasis formation in different tumor entities. Saffron extracts reduced DCLK1 with crocin being responsible for this reduction. Saffron’s anti-proliferative and anti-migratory effects in MACC1-expressing cells are mediated by crocin through DCLK1 down-regulation. This research is the first identification of saffron-based compounds restricting cancer cell proliferation and motility progression via the novel target MACC1.

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“…Crocin, the major bioactive compound in Saffron has anticancer properties on Balb/c female mice that prevent metastasis of triple negative breast cancer in murine models at a dose of 200 mg/kg, s.c., three times a week (Arzi, Farahi, et al, 2018). Crocin, at a dose of 200 mg/kg, i.p.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Through this treatise, we have tried to present a clear review about the benefits of some selected spices in preventing cancer, which has become the emperor of all maladies. From ancient times, we use ↓ FZD7, NEDD9, VIM, and VEGF-α genes and ↑ E-cadherin in 4T1 cells Arzi, Farahi, et al (2018) Lung cancer cells Caspase-8,9,3 mediated cell apoptosis in A549 and H446 cells Liu, Ye, et al, 2014;Liu, Schmitz, et al, 2014 Crocetin Breast cancer cells ↓ Migration through Wnt/β-catenin pathway Arzi, Farahi, et al (2018) ↓ MMP in MDA-MB-231 cells Chryssanthi et al (2011) Colon cancer cells ↓ NF-κB, VEGF and MMP-9 in DU-145 cells xenografts Liu, Ye, et al, 2014;Liu, Schmitz, et al, 2014 Black cumin Jiang, Zhu, Huang, et al, 2017; 20 mg/kg ↑ Apoptosis, ↓NF-ΑB signaling…”

Section: Con Clus I On and Future Per S Pec Tive Smentioning

confidence: 99%

Curry versus cancer: Potential of some selected culinary spices against cancer with in vitro, in vivo, and human trials evidences

et al. 2020

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Spices are dietary agents with immense potential for cancer chemo-prevention. A wide variety of spices are extensively used as food flavoring agents which possess potent antioxidant, anti-inflammatory, and anticancer properties due to the presence of certain bio-active compounds in them. In vitro, in vivo studies and clinical trials of selected spices against various types of cancer are being specified in this review. Effect of certain putative dietary spices namely turmeric, clove, garlic, ginger, fennel, black cumin, cinnamon, pepper, saffron, rosemary, and chilli along with its role in cancer are being discussed. Literature search was conducted through PubMed, Google scholar, Science direct, and Scopus using the keywords "spice," "cancer," "natural medicine," "herbal compound," "bioactive compounds." About 4,000 published articles and 127 research papers were considered to grab the brief knowledge on spices and their anticancer potential on a predefined inclusion and exclusion criteria. Practical application: Historically, spices and herbs are known for its traditional flavor, odor, and medicinal properties. Intensified risk of chronic and pervasive clinical conditions and increased cost of advanced drug treatments have developed a keen interest among researchers to explore the miscellaneous properties of herbal spices. Cancer is one of the deleterious causes of mortality affecting a huge number of populations worldwide. Arrays of cancer treatments including surgery, chemotherapy, and radiation therapy are used to compromise the disease but effective only when the size of the tumor is small. So, an effective treatment need to be developed that produces less side effects and herbal spices are found to be the promising agents. In this review, we illustrate about different in vitro, in vivo, and clinical studies of wide range of culinary spices having antineoplastic potential.

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Inhibitory Effect of Crocin on Metastasis of Triple-Negative Breast Cancer by Interfering with Wnt/β-Catenin Pathway in Murine Model

Cited by 42 publications

References 30 publications

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/β-Catenin Signaling Pathway and Glial Activation

Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells

Curry versus cancer: Potential of some selected culinary spices against cancer with in vitro, in vivo, and human trials evidences

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