Inhibitory Effect of Dimethyl Sulfoxide on Nuclear Factor-κB Activation and Intercellular Adhesion Molecule 1 Gene Expression in Septic Rats

Chang, Cheow K.; Llanes, Sheila; Schumer, William

doi:10.1006/jsre.1998.5527

Cited by 40 publications

(26 citation statements)

References 43 publications

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“…Once activated, NF-jB transcriptionally regulates many cellular genes implicated in early immune, acute phase, and inflammatory responses. The amount of activated NF-jB correlates with the degree of mucosal inflammation [30,31]. Indeed, in our study, increases in MDA, PGE2, and TXB2 levels, increases in NF-j, TNF-a, and ICAM-1 expressions, and a decrease in GSH levels were detected in intestinal tissue of irradiated rats.…”

Section: Discussionsupporting

confidence: 61%

Preventive Effect of Pentoxifylline on Acute Radiation Damage via Antioxidant and Anti-inflammatory Pathways

Hepgül

Tanrikulu

Ünalp³

et al. 2009

Dig Dis Sci

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Section: Discussionsupporting

confidence: 61%

Preventive Effect of Pentoxifylline on Acute Radiation Damage via Antioxidant and Anti-inflammatory Pathways

Hepgül

Tanrikulu

Ünalp³

et al. 2009

Dig Dis Sci

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“…The activation of NF-κB depends on the cellular redox potential and a reduced intracellular GSH/oxidized GSH ratio. The amount of activated NF-κB correlates with the degree of mucosal inflammation [22][23][24]. In the present study, NF-κB positivity was strongest in the colonic tissue of TNBS-treated rats.…”

Section: Discussionsupporting

confidence: 60%

The Effect of Melatonin on TNBS-Induced Colitis

et al. 2006

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Ulcerative colitis is a multifactorial inflammatory disease of the colon and rectum with an unknown etiology. The present study was undertaken to investigate the effect of melatonin administration on oxidative damage and apoptosis in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Rats were divided into four groups as follows: Group 1 (n=8)-T-NBS colitis; Group 2 (n=8)--melatonin, 10 mg/kg/day ip, for 15 days in addition to TNBS; Group 3 (n=8)--melatonin alone, 10 mg/kg/day ip, for 15 days; and Group 4 (n=8)-isotonic saline solution, 1 ml/rat ip, for 15 days (sham control group). Colonic myeloperoxidase (MPO) activities, malondialdehyde (MDA) levels, and glutathione (GSH) levels are indicators of oxidative damage, while caspase-3 activities reveal the degree of apoptosis of the colonic tissue. In all TNBS-treated rats, colonic MPO activity and MDA levels were found to be increased significantly compared to those in the sham group. Colonic MPO activity and MDA levels were significantly lower in the melatonin treatment group compared to TNBS-treated rats. GSH levels of colonic tissues were found to be significantly lower in TNBS-treated rats compared to the sham group. Treatment with melatonin significantly increased GSH levels compared to those in TNBS-treated rats. Caspas-3 activity of colonic tissues was found to be significantly higher in TNBS-treated rats compared to the sham group. Treatment with melatonin significantly decreased caspase-3 activity compared to that in TNBS-treated rats. These results imply a reduction in mucosal damage due to anti-inflammatory and anti-apoptotic effects of melatonin.

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“…107,108 DMSO can inhibit sepsis-induced hepatic NF-B activation and the activation of ICAM-1 gene expression in septic rats. 108 DMSO also has recently been shown to inhibit dimethylnitrosamine-induced hepatic fibrosis in rats. 107 Vitamin C, which is a known potent antioxidant can inhibit NF-B activation by TNF.…”

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confidence: 98%

Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair

Ali¹,

Mann²

2004

Cell Biochemistry & Function

139

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Activation of transcription factors plays a pivotal role in many signal transduction pathways. Of particular interest is NF-kappaB, which is present in the cytoplasm in an inactive form, where it can be activated in response to many different stress conditions such as infection, inflammation, heat shock etc. It has also been associated with apoptosis and tissue repair. Modulation of signal transduction events that mediate activation of NF-kappaB seems to have a great potential in not only treating many disease conditions, but also in tissue repair. The present review article is an attempt to put together many different conditions where the NF-kappaB activation pathway appears to be crucial in transducing signals under stress conditions, and to explore the possibility of its modulation as a targeted treatment modality.

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Inhibitory Effect of Dimethyl Sulfoxide on Nuclear Factor-κB Activation and Intercellular Adhesion Molecule 1 Gene Expression in Septic Rats

Cited by 40 publications

References 43 publications

Preventive Effect of Pentoxifylline on Acute Radiation Damage via Antioxidant and Anti-inflammatory Pathways

Preventive Effect of Pentoxifylline on Acute Radiation Damage via Antioxidant and Anti-inflammatory Pathways

The Effect of Melatonin on TNBS-Induced Colitis

Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair

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