Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage

Cosmeceuticals Derived from Bioactive Substances Found in Marine Algae

“…In addition, phlorotannins are found to exhibit inhibitory effects on melanogenesis as well as provide protection against photo-oxidative stress induced by UVB radiation [38]. Melanin is the major pigment responsible for the color of human skin and sometimes may be over stimulated due to chronic sun exposure or other hyperpigmentation diseases.…”

“…Therefore, dieckol from E. cava presented strong tyrosinase inhibitory and melanin synthesis inhibitory activities. Hence, dieckol may be useful as a natural whitening agent [36][37][38]49].…”

“…Marine macroalgae are a rich source of various phenolic antioxidant compounds [35][36][37][38][39]. These compounds exhibit a wide range of physiological properties, such as anti-allergenic, anti-artherogenic, anti-inflammatory, anti-microbial, anti-thrombotic, cardioprotective, vasodilatory, and antioxidant effects [1,36,37,40,41].…”

“…Tyrosinase, a copper-containing mono oxygenase, is a key enzyme that catalyses melanin synthesis in melanocytes [37]. It catalyses the hydroxylation of tyrosine into Dihydroxy Phenylalanine (DOPA) and other intermediates [38].…”

“…Phlorotannins were also found to exert a ROS scavenging effect. The effects of phlorotannins on cell viability in UVB radiation-induced fibroblasts were measured via a MMT assay [38,52] and were shown to exhibit inhibitory effects on intracellular oxidative damage induced by UVB radiation, with antioxidant activities associated with an improvement in cell viability [38].…”