Inhibitory Effect of Eco-Friendly Naturally Synthesized Silver Nanoparticles from the Leaf Extract of Medicinal Detarium microcarpum Plant on Pancreatic and Cervical Cancer Cells

Adebayo, Ismail Abiola; Arsad, Hasni; Gagman, Haladu Ali; Ismail, Noor Zafirah; Samian, Mohammed Razip

doi:10.31557/apjcp.2020.21.5.1247

Cited by 21 publications

(8 citation statements)

References 31 publications

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“…As a result, anti-breast cancer compounds may be found in the stem bark of these plants [ 59 ]. dAgNps inhibited HeLa cell proliferation with IC 50 values of 31.5 μ g/mL [ 79 ]. The chloroform and ethyl acetate extracts were the most effective at inhibiting osteosarcoma cells.…”

Section: Resultsmentioning

confidence: 99%

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Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Abdulrahman

2022

Advances in Pharmacological and Pharmaceutical Sciences

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Historically, natural products have been the principal source of medications for the treatment of human diseases. Traditional medical practitioners employ Detarium microcarpum as a treatment for diabetes, malaria, wounds, inflammation, and even cancer. This study emphasizes the importance of harmonizing D. microcarpum research so that results from various sources may be directly compared to reach a scientific conclusion. We searched Google Scholar, Science Direct, Google.com, Wiley, PubMed, Hindawi, and Springer for research papers on Detarium microcarpum. This analysis excludes untrustworthy online data, thesis papers, and review publications on D. microcarpum. The leaves and stem bark were shown to have high antioxidant, anti-inflammatory, antibacterial, antidiabetic, and anticancer properties. The study also discovered that too much consumption is harmful. Polyphenols and flavonoids were the most commonly reported compounds. However, human safety and efficacy are yet to be fully evaluated, and further well-designed clinical trials are needed to confirm preclinical findings. The leaves and stem bark extracts and isolated compound mechanism of action should be investigated. It is necessary to set a standard dose and ensure its safety.

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Section: Resultsmentioning

confidence: 99%

“…HeLa cell growth was decreased by dAgNps with IC 50 values of 31.5 μg/mL. [79] Notes: S/N � serial number.…”

Section: Aqueousmentioning

confidence: 99%

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Abdulrahman

2022

Advances in Pharmacological and Pharmaceutical Sciences

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“…Silver nanoparticles synthesized from phytochemicals (plant compounds) have been found to have antimicrobial, anticancer, antioxidant, and antidiabetic properties [ 15 ]. For instance, silver nanoparticles synthesized from the phytochemicals of Alternanthera sessilis, Dendrophthoe falcata, Albizia adianthifolia, Morinda citrifolia, Detarium microcarpum, and Artemisia turcomanica were reported to have antiproliferative effects on the growth of prostate cancer (PC3), breast cancer (MCF7), lung cancer (A549), cervical cancer (HeLa), pancreatic cancer, and gastric cancer (AGS) cells, respectively [ 14 , 16 – 20 ]. Hence, owing to the fact that there is a pressing need for effective therapy for leukemia, in this study, we investigated the potency of the silver nanoparticles synthesized from B. dalzielii stem bark metabolites to inhibit the growth and proliferation of AML cell line, Kasumi-1 cells.…”

Section: Introductionmentioning

confidence: 99%

Boswellia dalzielii-Mediated Silver Nanoparticles Inhibited Acute Myeloid Leukemia (AML) Kasumi-1 Cells by Inducing Cell Cycle Arrest

Adebayo

Usman

Shittu

et al. 2020

Bioinorganic Chemistry and Applications

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Background. Acute myeloid leukemia (AML) persists to be a major health problem especially among children as effective chemotherapy to combat the disease is yet to be available. Boswellia dalzielii is a well-known herb that is traditionally used for treatment and management of many diseases including degenerative diseases. In this study, silver nanoparticles were synthesized from the phytochemicals of B. dalzielii stem bark aqueous extract. The silver nanoparticles were characterized by carrying out Fourier Transform Infrared (FTIR) spectroscopy, Energy Filtered Scanning Electron Microscopy (FESEM), X-ray diffraction, and Dynamic Light Scattering (DLS) analyses. Antioxidant capacity of the nanoparticles was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and the antiproliferative effect of the nanoparticles on Kasumi-1 leukemia cells was investigated using PrestoBlue assay. Flow cytometry analysis was performed to observe the effect of the nanoparticles on the leukemia cell cycle progression. Results. Our findings revealed that the synthesized silver nanoparticles were formed from electrons of the plant phytochemicals which include aromatic compounds, ethers, and alkynes. FESEM analysis revealed that the sizes of the nanoparticles range from 12 nm to 101 nm; however, DLS analysis estimated a larger average size of the nanoparticles (108.3 nm) because it measured the hydrodynamic radii of the nanoparticles. The zeta potential of the nanoparticles was −16 nm, and the XRD pattern of the nanoparticles has distinct peaks at 38.02°, 42.94°, 64.45°, 77.20°, and 81.47°, which is typical of face-centered cubic (fcc) structure of silver. The Trolox Equivalence Antioxidant Capacity (TEAC) of the nanoparticles was estimated to be 300.91 μM Trolox/mg silver nanoparticles. The nanoparticles inhibited Kasumi-1 cell proliferation. The half minimal inhibitory concentrations (IC50s) that inhibited Kasumi-1 cell proliferation are 49.5 μg/ml and 13.25 μg/ml at 48 and 72 hours, respectively. The nanoparticles induced cell cycle arrest in the Kasumi-1 cells at S (5% increase) and G2/M (3% increase) phases. Conclusion. The nanoparticles synthesized from the stem bark extract of B. dalzielii inhibit the growth of Kasumi-1 leukemia cells by activating cell cycle arrest; thus, they are potential antileukemic agents.

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“…Due to the absence of special clinical manifestations in the early stage of pancreatic cancer, the disease has reached the middle and late stage when most patients are diagnosed clinically, and only 15%~20% of patients can be treated with surgical resection, and about 50% of patients can be complicated with distant metastasis (3). The incidence of pancreatic cancer is related to genetic and environmental factors (4). Previous studies have shown that chronic pancreatitis, family inheritance and smoking can increase the risk of pancreatic cancer (5,6).…”

Section: Introductionmentioning

confidence: 99%

Analysis of levels and Clinical value of CA19-9, NLR and SIRI in patients with Pancreatic Cancer with different Clinical Features

Ziyu

Zhang³

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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This study aimed to investigate the levels of cancer antigen 19-9 (CA19-9), neutrophil/lymphocyte ratio (NLR) and systemic immune-inflammatory index (SIRI) in patients with pancreatic cancer with different clinical features and their clinical value. For this purpose, 78 patients with pancreatic cancer treated in our hospital from January 2018 to January 2021 were divided into two groups according to the NLR and SIRI calculated by blood routine and biochemical examination before operation. To observe and analyze the relationship between serum CA19-19 levels, clinical features and NLR and SIRI values in patients with different clinical stages and tumor diameter, and the diagnostic value of CA19-9, NLR and SIRI in pancreatic cancer. The results showed that the level of serum CA19-9 in patients with stage IV pancreatic cancer was significantly higher than that in patients with stage I, II and III, and the level of CA19-9 in patients with stage III was higher than that in patients with stage I and II, and the level of CA19-9 in patients with stage II was higher than that in patients with stage I. The level of CA19-9 in patients with pancreatic cancer with tumor diameter ≥ 5cm was significantly higher than that in patients with tumor diameter < 5cm. The percentage of patients with age ≤ 60 years old in high NLR group (83.78%) was significantly higher than that in low NLR group (63.41%), and the rate of patients with tumor diameter ≥ 5cm in the high SIRI group (54.05%) was significantly higher than that in low NLR group (26.83%). The rate of patients with tumor diameter ≥ 5cm in the high SIRI group (61.92%) was significantly higher than that in the low SIRI group (31.58%). Among the single indexes, the sensitivity of CA19-9 in the diagnosis of pancreatic cancer was the highest (93.10%). The specificity of Siri in the diagnosis of pancreatic cancer was 89.70%. The sensitivity and specificity of combined detection were 89.7% and 70.00%, respectively. In general, the level of serum CA19-9 in patients with pancreatic cancer increases gradually with the increase of clinical stage and tumor diameter. NLR value is related to patient age and tumor diameter, and SIRI value is related to tumor diameter. Combined detection of CA19-9, NLR and SIRI are of higher value in the early diagnosis of pancreatic cancer.

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Inhibitory Effect of Eco-Friendly Naturally Synthesized Silver Nanoparticles from the Leaf Extract of Medicinal Detarium microcarpum Plant on Pancreatic and Cervical Cancer Cells

Cited by 21 publications

References 31 publications

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Biological Activity and Chemical Composition of Detarium microcarpum Guill. and Perr—A Systematic Review

Boswellia dalzielii-Mediated Silver Nanoparticles Inhibited Acute Myeloid Leukemia (AML) Kasumi-1 Cells by Inducing Cell Cycle Arrest

Analysis of levels and Clinical value of CA19-9, NLR and SIRI in patients with Pancreatic Cancer with different Clinical Features

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