Inhibitory effect of edible plant extracts on 12‐<i>O</i>‐tetradecanoylphorbol–13‐acetate‐induced ear oedema in mice

Yasukawa, Ken; Yamaguchi, Arisa; Arita, Jiro; Sakurai, Shogo; Ikeda, Atsuo; Takido, Michio

doi:10.1002/ptr.2650070218

Cited by 41 publications

(22 citation statements)

References 18 publications

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“…Pure humulone has been described to inhibit TPA-and arachidonic acid-induced ear edema in mice and TPA-induced tumor formation in mice skin [32,52]. Furthermore, the inhibitory effect on the transcriptional activation of COX-2 has been demonstrated in cultured cells [34] and mouse skin [33].…”

Section: Discussionmentioning

confidence: 96%

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Cleemput

Heyerick

Libert

et al. 2009

Molecular Nutrition Food Res

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Hop (Humulus lupulus L.) is an essential ingredient of beer, where it provides the typical bitter taste, but is also applied in traditional folk medicine for sedative and antibacterial purposes. In this study, we demonstrate and compare the anti-inflammatory effect of various classes of hop bitter acids (HBA), including alpha-acids (AA), beta-acids (BA), and iso-alpha-acids (IAA), in fibroblasts, which are important players in the inflammatory response. All three studied classes of HBA blocked the tumor necrosis factor alpha (TNF)-induced production of the cytokine IL6, and inhibited the transactivation of the pro-inflammatory transcription factors nuclear factor kappa B (NF-kappaB), activator protein-1 (AP-1), and cAMP-response element-binding protein (CREB). In this respect, the six-membered ring compounds AA and BA showed equal potency, whereas the five-membered ring compounds, IAA, were effective only when used at higher concentrations. Furthermore, with regard to the mechanism of NF-kappaB suppression, we excluded a possible role for glucocorticoid receptor alpha (GRalpha), peroxisome proliferators-activated receptor alpha/gamma (PPARalpha or PPARgamma), nuclear receptors (NRs) that are also known to inhibit inflammation by directly interfering with the activity of pro-inflammatory transcription factors. Interestingly, combining hop acids and selective agonists for GRalpha, PPARalpha, or PPARgamma resulted in additive inhibition of NF-kappaB activity after TNF treatment, which may open up new avenues for combinatorial anti-inflammatory strategies with fewer side effects. Finally, systemic administration of HBA efficiently inhibited acute local inflammation in vivo.

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Section: Discussionmentioning

confidence: 96%

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Cleemput

Heyerick

Libert

et al. 2009

Molecular Nutrition Food Res

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“…It would be particularly useful to develop a method of prevention at the promotion stage of carcino genesis, as such a method may be applicable even after exposure to tumor-initiating agents, which seems, in many cases, to be unavoidable in human life. Our earlier studies demonstrated that some extracts from edible plants and crude drugs inhibited TPA-induced inflamma tory ear edema and active compounds were separated from their extracts [4,5], In this context, the topical application of the antitu mor-promoting agent, humulon, afforded a high degree of protection against tumor formation in mouse skin. In addition, humulon inhibited AA-induced inflammatory ear edema in mice, which is an acute skin inflammation model due to increased production of endogenous leukotrienes and prostaglandins [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Humulon, one of the bitters in the hop, has been used as an antibiotic [2] and antifungal [3] agent. In our previous study, humulon was isolated from the hop and found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammatory ear edema in mice [4], Furthermore, in this study, topical application of humulon markedly suppressed the promo tion of skin tumors induced by twice weekly application of TPA following initiation by a single application of 7,12-dimethylbenz[a]anthracene (DMBA) in ICR mice.…”

Section: Introductionmentioning

confidence: 99%

Humulon, a Bitter in the Hop, Inhibits Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

Yasukawa

Takeuchi²,

Takido³

1995

Oncology

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Humulon, one of the bitters in the hop, was isolated from the female flowers of Humulus lupulus. This component has inhibitory activity against 12-O-tetra-decanoylphorbol-13-acetate (TPA)-induced inflammation. At 1 mg/mouse, humulon inhibited markedly the tumor-promoting effect of TPA (1 μg/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]an-thracene (50 μg/mouse). Furthermore, humulon inhibited arachidonic acid-induced inflammatory ear edema in mice.

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“…Peppermint ( M. piperita ) oil is one of the most popular and widely used essential oils, mostly because of its main components, Menthol, and menthone [4]. Previous studies have shown antiviral [5], antibacterial [6, 7], antifungal [6, 8–10], antibiofilm formation [11–13], radioprotective [14], antioedema [15], analgesic [16], and antioxidant activities [6] of the EO and methanolic extracts of herbal parts and callus cultures of M. piperita . In addition, M. piperita EO has been shown to cause inhibitory effects against radial fungal growth and aflatoxin production by Aspergillus species [17].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition, Antifungal and Antibiofilm Activities of the Essential Oil ofMentha piperitaL.

et al. 2012

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Variations in quantity and quality of essential oil (EO) from the aerial parts of cultivated Mentha piperita were determined. The EO of air-dried sample was obtained by a hydrodistillation method and analyzed by a gas chromatography/mass spectrometry (GC/MS). The antifungal activity of the EO was investigated by broth microdilution methods as recommended by Clinical and Laboratory Standards Institute. A biofilm formation inhibition was measured by using an XTT reduction assay. Menthol (53.28%) was the major compound of the EO followed by Menthyl acetate (15.1%) and Menthofuran (11.18%). The EO exhibited strong antifungal activities against the examined fungi at concentrations ranging from 0.12 to 8.0 μL/mL. In addition, the EO inhibited the biofilm formation of Candida albicans and C. dubliniensis at concentrations up to 2 μL/mL. Considering the wide range of the antifungal activities of the examined EO, it might be potentially used in the management of fungal infections or in the extension of the shelf life of food products.

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Inhibitory effect of edible plant extracts on 12‐O‐tetradecanoylphorbol–13‐acetate‐induced ear oedema in mice

Cited by 41 publications

References 18 publications

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Humulon, a Bitter in the Hop, Inhibits Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

Chemical Composition, Antifungal and Antibiofilm Activities of the Essential Oil ofMentha piperitaL.

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