Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice

Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress

“…Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) is a flavone derived from Artemisia asiatica and has been shown to have many pharmacological activities involving anti-oxidant [21,22], anti-inflammatory [23,24], antiatherogenic [25] and anti-cancer effects [26]. For example, it has been reported that a pharmaceutical agent containing eupatilin protects against gastric mucosal injury [27] and carrageenan-induced paw edema [24].…”

“…For example, it has been reported that a pharmaceutical agent containing eupatilin protects against gastric mucosal injury [27] and carrageenan-induced paw edema [24]. Moreover, animal studies have shown that eupatilin ameliorates acetaminophen-and carbon tetrachloride-induced acute liver injury [28] and dimethyl nitrosamine-induced liver fibrosis [29].…”

Gastroprotective effects of the isopropanol extract of Artemisia princeps and its gastroretentive floating tablets on gastric mucosal injury

“…Detailed MS data and absorption maxima data of these peaks are listed in Table II. These compounds have been previously identified in Artemisia princeps (19,20). The results show that the botanical origin of the raw material was re-confirmed by chemical fingerprinting, and the major components of the extract were anti-oxidant phenolic compounds such as eupatilin, jaceosidin, and 3,5-dicaffeoylquinic acid.…”

Proteasome Targeted Therapies in Rheumatoid Arthritis

“…Blocking of IKK in vitro with a dominant negative adenoviral construct was shown to inhibit the induction of IL-6, IL-8, and intercellular adhesion molecule-1 (ICAM-1) after stimulation with IL-1 or TNF- . The significance of NF-κB in inflammatory joint disease has been validated by numbers of arthritis models such as carrageenan-induced paw edema, collagen-induced arthritis and adjuvant-induced arthritis [Min et al, 2009, Campo et al, 2011, Ahmed et al, 2010. In animal models of arthritis the activation of NF-κB appears to precede the onset of disease, and the blockade of NF-κB decreases arthritis severity [Tsao et al, 1997;Ahmed et al, 2010].…”