Inhibitory effect of follicular fluid on RNA synthesis of rat granulosa cells in vitro

Bernard, Jean‐Paul; Psychoyos, A

doi:10.1530/jrf.0.0490355

Cited by 9 publications

(1 citation statement)

References 13 publications

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“…The earliest studies from Nalbandov and colleagues suggested the ovum as the possible source of this inhibitor (EI-Fouly et al 1970). Although the cell of origin has not been settled, numerous laboratories have now shown that factors in follicular fluid exert an inhibitory effect on various aspects of the function of follicular cells, including progesterone secretion (Ledwitz-Rigby et al 1977;Shemesh 1979), morphological luteinization (Bernard 1973;Alexander et al 1978;Bernard and Chretien 1978), RNA synthesis (Bernard and Psychoyos 1977), prostaglandin synthesis (She mesh 1979) and either adenylate cyclase or cAMP accumulation (Ledwitz-Rigby et al 1977;Kraiem et al 1978;Amsterdam et al 1979aAmsterdam et al , 1979bRigby et al 1980). Most studies have been performed with pig or cow follicles, presumably for technical reasons.…”

Section: Luteinization Inhibitormentioning

confidence: 99%

Peptide Regulators in the Ovarian Follicle

Hammond¹

1981

Aust. Jnl. Of Bio. Sci.

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Data generated within the last several years have shown that follicular fluid contains substances, presumably peptide in nature, which exert potentially important effects on granulosa cells and the oocyte. This review briefly summarizes the current evidence concerning the nature and importance of these putative regulators including the luteinization inhibitor, oocyte maturation inhibitor, inhibitors of the binding of luteinizing hormone and follicle stimulating hormone, stimulators of ornithine decarboxylase and intrafollicular peptides with gonadotrophin-releasing activity. Although the existence of such activities has been clearly demonstrated, the evidence for a regulatory role of these agents in the control of ovarian physiology is not compelling. However, their occurrence must now be taken into account in our attempts to understand the mechanism of follicular growth, differentiation and atresia.

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Section: Luteinization Inhibitormentioning

confidence: 99%

Peptide Regulators in the Ovarian Follicle

Hammond¹

1981

Aust. Jnl. Of Bio. Sci.

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Leukaemia inhibitory factor and the regulation of pre‐implantation development of the mammalian embryo

Stewart

1994

Molecular Reproduction Devel

115

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This paper reviews the evidence that certain growth factors, particularly leukaemia inhibitory factor (LIF), play a crucial role in regulating the development of the pre-implantation mammalian embryo. LIF was originally implicated in regulating the early development of the mouse embryo because it inhibited the differentiation of embryonic stem (ES) cells, pluripotential cells derived from the inner cell mass of the blastocyst. Subsequent studies on its role in vivo revealed, surprisingly, that it is essential for the growth rather than the differentiation of the blastocyst. In vivo, overtly normal blastocysts can be produced in a LIF-deficient environment that are capable of forming viable fertile adults. However, in the absence of LIF, they fail to implant and enter into a state resembling that exhibited by blastocysts undergoing delayed implantation, which is characterized by a cessation of cell proliferation. This failure to implant occurs because the principle sites of LIF production are the endometrial glands of the uterus. These synthesize and secrete LIF at implantation, with LIF synthesis essential for implantation. Preliminary evidence indicates that LIF synthesis is required both by the uterus for it to undergo decidualization and by the blastocyst for implantation. These data indicate that the maternal environment plays a crucial role in the development and growth of the pre-implantation embryo, by supplying factors that regulate these processes in the embryo.

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The Influence of Follicular Fluid on Progesterone Secretion by Porcine Granulosa Cells in Vitro

Ledwitz-Rigby

Rigby

1979

Advances in Experimental Medicine and Biology

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Inhibitory effect of follicular fluid on RNA synthesis of rat granulosa cells in vitro

Cited by 9 publications

References 13 publications

Peptide Regulators in the Ovarian Follicle

Peptide Regulators in the Ovarian Follicle

Leukaemia inhibitory factor and the regulation of pre‐implantation development of the mammalian embryo

The Influence of Follicular Fluid on Progesterone Secretion by Porcine Granulosa Cells in Vitro

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