Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture

Yagihashi, Satoru; Miura, Yutaka; Yagasaki, Kazumi

doi:10.1007/s10616-008-9121-8

Cited by 60 publications

(42 citation statements)

References 21 publications

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“…Such a benefit has also been observed with febuxostat in left ventricular hypertrophy in mice [25] and congestive heart failure in dogs [26]; wherein febuxostat has restored myocardial functions. This beneficial effect can be explained by inhibition of xanthine oxidase by febuxostat with a resultant decrease in free radical production and inhibition of apoptosis, consistent with the effects previously reported with other xanthine oxidase inhibitors such as allopurinol [10] and 6-gingerol [27].…”

Section: Discussionsupporting

confidence: 88%

Febuxostat ameliorates doxorubicin-induced cardiotoxicity in rats

Krishnamurthy

Rani

Bharti

et al. 2015

Chemico-Biological Interactions

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Section: Discussionsupporting

confidence: 88%

Febuxostat ameliorates doxorubicin-induced cardiotoxicity in rats

Krishnamurthy

Rani

Bharti

et al. 2015

Chemico-Biological Interactions

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“…These firmly suggest that [6]-gingerol can effectively be used for the treatment of gastric cancer (Ishiguro et al, 2007). Yagihashi et al (2008) reported that [6]-gingerol inhibited both proliferation and invasion of hepatoma cells in a dosedependent manner at concentrations of 6.25-200 muM (proliferation) and 50-200 muM (invasion). Suppression of hepatoma cell proliferation by [6]-gingerol may be due to cell cycle arrest and apoptosis induction.…”

Section: Cancer Insurgence and Gingermentioning

confidence: 86%

Ginger and its Health Claims: Molecular Aspects

Butt

Sultan

2011

Critical Reviews in Food Science and Nutrition

170

115

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Recent research has rejuvenated centuries-old traditional herbs to cure various ailments by using modern tools like diet-based therapy and other regimens. Ginger is one of the classic examples of an herb used for not only culinary preparations but also for unique therapeutic significance owing to its antioxidant, antimicrobial, and anti-inflammatory potential. The pungent fractions of ginger, namely gingerols, shogaols, paradols, and volatile constituents like sesquiterpenes and monoterpenes, are mainly attributed to the health-enhancing perspectives of ginger. This review elucidates the health claims of ginger and the molecular aspects and targets, with special reference to anticancer perspectives, immunonutrition, antioxidant potential, and cardiovascular cure. The molecular targets involved in chemoprevention like the inhibition of NF-κB activation via impairing nuclear translocation, suppresses cIAP1 expression, increases caspase-3/7 activation, arrests cell cycle in G2 + M phases, up-regulates Cytochrome-c, Apaf-1, activates PI3K/Akt/I kappaB kinases IKK, suppresses cell proliferation, and inducts apoptosis and chromatin condensation. Similarly, facts are presented regarding the anti-inflammatory response of ginger components and molecular targets including inhibition of prostaglandin and leukotriene biosynthesis and suppression of 5-lipoxygenase. Furthermore, inhibition of phosphorylation of three mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and c-Jun N-terminal kinase (JNK) are also discussed. The role of ginger in reducing the extent of cardiovascular disorders, diabetes mellitus, and digestive problems has also been described in detail. Although, current review articles summarized the literature pertaining to ginger and its components. However, authors are still of the view that further research should be immediately carried out for meticulousness.

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“…It was demonstrated that 6-, 8-, and 10-gingerols and 6-shogaol showed efficacy in anti-inflammatory, antibacterial, antipyretic, antilipidemic, antitumorigenic, and antiangiogenic effects (5,(21)(22)(23)(24)(25)(26)(27). In addition, 6-gingerol was shown to inhibit leukotriene A 4 hydrolase (LTA 4 H) and suppress anchorage-independent cancer cell growth in colorectal cancer cells (HCT116 and HT29) with IC 50 's of 50 and 35 μM, respectively (28).…”

Section: Introductionmentioning

confidence: 99%

Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans

Zick

et al. 2011

AAPS J

106

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Abstract. Ginger extracts have been studied in various clinical trials for different indications. However, the pharmacokinetics of the ginger active constituents in human biological matrices is not well investigated. This study aims to develop a LC-MS/MS method for simultaneous measurement of 6-, 8-, and 10-gingerols and 6-shogaol and study their pharmacokinetics in human plasma and colon tissues. A sensitive LC-MS/MS method was established and validated with a low limit of quantification of 2-5 ng/ mL. The intra-and inter-day accuracy ranged from −7.3% to 10.4% and from −9.4% to 9.8%, respectively. The intra-and inter-day precision ranged from 0.9% to 10.9% and from 2.0% to 12.4%, respectively. The glucuronide and sulfate metabolites of 6-, 8-, and 10-gingerols and 6-shogaol in plasma and colon tissues were quantified after hydrolysis with β-glucuronidase and sulfatase. After oral dosing of 2.0 g ginger extracts in human, free 10-gingerol and 6-shogaol were detected in plasma with peak concentrations (9.5±2.2 and 13.6±6.9 ng/mL, respectively) at 1 h after oral administration, but no free 6-gingerol and 8-gingerol were detected in plasma from 0.25 to 24 h. The peak concentrations of glucuronide metabolites of 6-, 8-, and 10-gingerols and 6-shogaol were 0.47±0.31, 0.17±0.14, 0.37±0.19, and 0.73±0.54 μg/mL at 1 h, respectively. The peak concentrations of the sulfate metabolites of 6-, 8-, and 10-gingerols and 6-shogaol were 0.28±0.15, 0.027±0.018, 0.018±0.006, and 0.047±0.035 μg/mL at 1 h, respectively. Very low concentrations (2-3 ng/mL) of 10-gingerol glucuronide and sulfate were found in colon tissues. Pharmacokinetic analysis showed that half-lives of these four analytes and their metabolites were 1-3 h in human plasma. No accumulation was observed for 6-, 8-, and 10-gingerols and 6-shogaol and their metabolites in both plasma and colon tissues after multiple daily dosing.

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Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture

Abstract: Effect of [6]-gingerol, a major pungent component in ginger, on the proliferation of a rat ascites hepatoma AH109A cells was investigated by measuring [

Cited by 60 publications

References 21 publications

Febuxostat ameliorates doxorubicin-induced cardiotoxicity in rats

Febuxostat ameliorates doxorubicin-induced cardiotoxicity in rats

Ginger and its Health Claims: Molecular Aspects

Examination of the Pharmacokinetics of Active Ingredients of Ginger in Humans

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