Inhibitory Effect of Heparin on Herpes Simplex Virus

Nahmias, André J.; Kibrick, Sidney

doi:10.1128/jb.87.5.1060-1066.1964

Cited by 160 publications

(78 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This has already been proposed for the treatment of both hepatitis C (He et al, 2015) and Ebola virus (Sakurai et al, 2015) infections. Heparin, the widely used anticoagulant, has potentially attractive features including activity against attachment and entry of the enveloped viruses, human simplex (HSV) (Herold et al, 1996;Nahmias and Kibrick, 1964), human immunodeficiency (HIV) (Baba et al, 1988), SARS coronavirus (Vicenzi et al, 2004), and influenza (H5N1) . Here, we explore the effects of heparin on ZIKV infection in human neural progenitor cells (hNPCs) with particular regard to virus replication and induction of cytopathic effects (CPE) resulting in cell death.…”

Section: Introductionmentioning

confidence: 99%

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

et al. 2017

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

et al. 2017

View full text Add to dashboard Cite

“…43 Heparan sulfate has been shown to block the initial phase of HSV infection. 57,58 More recent investigations revealed that glycoproteins from the HSV-1 and HSV-2 viruses are known to interact directly with 3-O-sulfated heparin, which is abundantly expressed on host cells. 54,[59][60][61][62][63] These studies suggest that the binding of heparan sulfate to gD prevents its interactions with host cell receptors.…”

Section: Influenza Virusmentioning

confidence: 99%

Systematic screening of viral entry inhibitors using surface plasmon resonance

Kumar

2017

Reviews in Medical Virology

View full text Add to dashboard Cite

Viral binding and entry into host cells for various viruses have been studied extensively, yielding a detailed understanding of the overall viral entry process. As cell entry is an essential and requisite process by which a virus initiates infection, it is an attractive target for therapeutic intervention. The advantages of targeting viral entry are an extracellular target site, relatively easy access for biological interventions, and lower toxicity. Several cell-based strategies and biophysical techniques have been used to screen compounds that block viral entry. These studies led to the discovery of inhibitors against HIV, HCV, influenza, Ebola, and RSV. In recent years, several compounds screened by fragment-based drug discovery have been approved as drugs or are in the final stages of clinical trials. Among fragment screening technologies, surface plasmon resonance has been widely used because it provides accurate information on binding kinetics, allows real-time monitoring of ligand-drug interactions, requires very small sample amounts to perform analyses, and requires no modifications to or labeling of ligands. This review focuses on surface plasmon resonance-based schemes for screening viral entry inhibitors.

show abstract

“…The broad antiviral activity of UTIb is shown in Table 1. Heparin, which may be used medically to prevent clotting, has narrow antiviral activity but deserves to be mentioned because of its potent activity against HIV-1 (Nahmias and Kibrick, 1964;Baba et al, 1988;Rider, 1997). Below we will consider the properties of the constitutive broadly active inhibitors, i.e.…”

Section: Serum: Innate Inhibitorsmentioning

confidence: 99%

Innate antiviral defenses in body fluids and tissues

et al. 2000

View full text Add to dashboard Cite

Innate, non-specific, resistance mechanisms are important barriers to pathogens, particularly delaying virus multiplication at the onset of infections. These innate defense mechanisms include a series of mechanical barriers, pre-existing inhibitory molecules, and cellular responses with antimicrobial activity. The antiviral activities of these innate inhibitors reside in a variety of partly characterized substances. This review presents the innate antiviral inhibitors in cell cultures, urine, serum, the gastrointestinal tract, the nervous system, tissues of crustaceans, and saliva. Medical adaptation of the innate antiviral defense mechanisms may be useful for prevention and treatment of viral infections.

show abstract

Inhibitory Effect of Heparin on Herpes Simplex Virus

Cited by 160 publications

References 20 publications

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Systematic screening of viral entry inhibitors using surface plasmon resonance

Innate antiviral defenses in body fluids and tissues

Contact Info

Product

Resources

About