Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin

Tseng, Tsui‐Hwa; Hsu, Jeng-Dong; Lo, Ming-Hsiang; Chu, Chia-Yih; Chou, Fen‐Pi; Huang, Chao-Lu; Wang, Chau‐Jong

doi:10.1016/s0304-3835(98)00010-x

Cited by 152 publications

(100 citation statements)

References 24 publications

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“…Ester and glycoside bonds of caffeic acid from the hydroxycinnamic acid group are of special interest (Borkowski 1993;Borkowski et al 1996). Furthermore, as it follows from literature data (Tseng et al 1998), protocatechuic acid from the hydroxybenzoic acid group, occurring in fruits, vegetables, and nuts, is the phenolic compound showing antioxidation and anticarcinogenic properties. It inhibits chemical carcinogenesis at the initiation and post-initiation stage of cancer in animals.…”

Section: Resultsmentioning

confidence: 92%

Secondary metabolites inSilphium integrifoliumin the first 2 years of cultivation

Kowalski¹

2004

New Zealand Journal of Crop and Horticultural Science

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Evaluation of secondary metabolite contents (essential oil, flavonoids, oleanosides, and phenolic acids) was made in leaves, inflorescences, and rhizomes of Silphium integrifolium during ontogenesis. It was found that the plant's rhizomes contained the highest level of essential oil (up to 0.61% v/w) and thus they are the most interesting raw material. Leaves contained the highest level of flavonoids (up to 1.31%). However, oleanosides occurred the most abundantly in inflorescences (4.59%). Inflorescences were characterised with the largest amounts of phenolic acids (up to 48.19 mg × 100 g -1 dry mass (DM) in total). It was found that caffeic and protocatechuic acids were the dominant phenolic acids in S. integrifolium. The optimum date of harvest was the period just before flowering.

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Section: Resultsmentioning

confidence: 92%

Secondary metabolites inSilphium integrifoliumin the first 2 years of cultivation

Kowalski¹

2004

New Zealand Journal of Crop and Horticultural Science

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“…Roselle calyx juice is a popular drink in Taiwan society. Protocatechuic acid (PA), a polyphenol containing a 3,4-dihydroxy substructure, is a compound derived from roselle calyx (Tseng et al, 1998;Ali et al, 2005). Several studies have indicated that roselle calyx possessed antioxidant, antihypertensive and antimutagenic activities in rats (Onyenekwe et al, 1999;Chewonarin et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

In vitro anti‐Helicobacter pylori activity of diallyl sulphides and protocatechuic acid

Liu

Hsu

Yin

2007

Phytotherapy Research

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The in vitro inhibitory effects of diallyl disulphide (DADS), diallyl trisulphide (DAT), roselle calyx extract and protocatechuic acid (PA) on the growth of Helicobacter pylori (15 susceptible, 11 clarithromycin-resistant and 9 metronidazole-resistant strains) were studied. The inhibition zone was determined after each agent had been heated at 25, 60, 100°C for 60 min. The minimal inhibitory concentration (MIC) of each agent was determined by the tube dilution assay. The results showed that heat treatment did not affect the anti-H. pylori activity of DADS, DAT, roselle calyx extract and PA, and the MIC values of these agents against test H. pylori strains were in the range 8 -64 mg/L. The time-kill study assay for DAT and PA at 1× × × × × MIC was monitored in Muller Hinton broth supplemented with 10% horse blood or mice stomach homogenate. Both DAT and PA inhibited the growth of all test H. pylori in broth and mice stomach homogenate ( p < < < < < 0.05); however, the inhibitory effects of these two agents were less in mice stomach homogenate than in broth (p < < < < < 0.05). DAT at 4, 6, 8, 10, 12, 14 mg/L and PA at 8, 16, 24, 32, 40, 48 mg/L were used for urease activity assay. These two agents significantly reduced urease activity of test H. pylori strains (p < < < < < 0.05), in which DAT and PA at 1× × × × × MIC reduced the urease activity of H. pylori to 70% and 40%, respectively. These agents, based on their lower MIC values and heat tolerance, might be useful in the prevention or therapy of H. pylori.

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“…They have also antimicrobial and antiviral properties [29] and, as components of the human diet in combination with antitumor drugs, can reduce side effects of the anticancer therapy [30][31][32]. PhAs regulate tumor promoting metabolic pathways and can inhibit tumor development [33,34]. In plants, PhAs play role as phytoalexins and also perform defensive functions against pathogenic agents.…”

Section: Introductionmentioning

confidence: 99%

Phenolic acids in Crithmum maritimum L. (Apiaceae) after Tytanit fertilization

et al. 2017

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Aerial parts and roots of Crithmum maritimum L. fertilized with Tytanit were investigated on the presence of phenolic acids (PhAs). Cinnamic and benzoic acid derivatives were quantified by use of validated RP-HPLC/DAD method. The amount of PhAs in fertilized plants (T) was higher than in control (C) plants (in the aerial parts: 2.16 mg/g and 1.28 mg/g dry weight, respectively, and in roots: 4.05 mg/g and 2.78 mg/g dry weight, respectively). The predominant PhA was the caffeic acid (83.2-94.2% of the total PhAs). After Tytanit treatment, amount of the caffeic acid rose from 667.41 µg/g in C to 1463.83 µg/g dry weight in the aerial parts of T, and in roots from 2251.74 µg/g in C to 3451.86 µg/g dry weight in T. Tytanit had also influence on the qualitative composition of PhAs; in extracts from aerial parts, some of PhAs (ferulic, chlorogenic, and syringic acids), absent in control, appeared after fertilization.

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Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin

Cited by 152 publications

References 24 publications

Secondary metabolites inSilphium integrifoliumin the first 2 years of cultivation

Secondary metabolites inSilphium integrifoliumin the first 2 years of cultivation

In vitro anti‐Helicobacter pylori activity of diallyl sulphides and protocatechuic acid

Phenolic acids in Crithmum maritimum L. (Apiaceae) after Tytanit fertilization

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