Inhibitory Effect of<i>Agaricu blazei</i>Murill Components on Abnormal Collagen Fiber Formation in Human Hepatocarcinoma Cells

Sorimachi, Kenji; Akimoto, Kazumi; Koge, Takashi

doi:10.1271/bbb.70700

Cited by 9 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was evidence that the mushroom could improve immune function and life quality of gynecological cancer patients taking chemotherapy [ 127 ]. Besides, the extract from A. blazei meycelial could decrease formation of abnormal collagen fiber in HCC cells [ 128 ], which might be very helpful since liver cirrhosis is highly implicated in the development of liver cancer. The anti-tumor property of A. blazei was also proved in Smmu 7721 hepatoma-bearing mice [ 129 ].…”

Section: Edible Macro-fungimentioning

confidence: 99%

Dietary Natural Products for Prevention and Treatment of Liver Cancer

et al. 2016

View full text Add to dashboard Cite

Liver cancer is the most common malignancy of the digestive system with high death rate. Accumulating evidences suggests that many dietary natural products are potential sources for prevention and treatment of liver cancer, such as grapes, black currant, plum, pomegranate, cruciferous vegetables, French beans, tomatoes, asparagus, garlic, turmeric, ginger, soy, rice bran, and some edible macro-fungi. These dietary natural products and their active components could affect the development and progression of liver cancer in various ways, such as inhibiting tumor cell growth and metastasis, protecting against liver carcinogens, immunomodulating and enhancing effects of chemotherapeutic drugs. This review summarizes the potential prevention and treatment activities of dietary natural products and their major bioactive constituents on liver cancer, and discusses possible mechanisms of action.

show abstract

Section: Edible Macro-fungimentioning

confidence: 99%

Dietary Natural Products for Prevention and Treatment of Liver Cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Aqueous extracts of AbM exhibit antimutagenic and anticlastogenic effects in vitro [72, 73], and protect against X‐irradiation in mice [74]. Furthermore, another AbM water extract inhibited abnormal collagen fibre formation in human hepatocarcinoma cells [75].…”

Section: Cancermentioning

confidence: 99%

Effects of the Medicinal Mushroom Agaricus blazei Murill on Immunity, Infection and Cancer

Hetland¹,

Johnson

Lyberg

et al. 2008

Scand J Immunol

View full text Add to dashboard Cite

Agaricus blazei Murill (AbM) is an edible, medicinal mushroom of Brazilian origin. It is used traditionally against a range of diseases, including cancer and chronic hepatitis, and has been cultivated commercially for the health food market. AbM has recently been shown to have strong immunomodulating properties, which has led to increasing scientific interest. In this article, we review current knowledge as to the immunological properties of AbM, and its possible clinical use in connection with infections and cancer. We also present some novel findings, which point to highly different biological potency between AbM extracts of different source and manufacturing.

show abstract

“…This indicates that AndoSan may also have a direct antiproliferative effect on myeloma cells, which may be clinically significant. In earlier studies an inhibitory/tumoricidal effect of Agaricus has been reported in fibrosarcoma [ 5 , 9 ] and ovarian cancer [ 6 ] and in human hepatocarcinoma [ 7 ] and leukemic cells [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…The fruiting body of AbM is rich in β -glucans, which is a potent stimulant of the innate immune system. β -Glucan from AbM has been shown to have an antitumor effect both in vitro (fibrosarcoma [ 5 ], ovarian cancer [ 6 ], hepatocarcinoma [ 7 ], and leukemia cells [ 8 ]) and in animal models (fibrosarcoma [ 9 ], multiple myeloma [ 10 ], and lung cancer [ 11 ]). It has therefore been assumed that the medicinal effect of AbM is mainly due to the immunostimulatory effect of β -glucans [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of theAgaricus blazeiMurrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study

Tangen

Tierens

Caers

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy with autologous stem cell support were randomized in a double blinded fashion to receive adjuvant treatment with the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients). Intake of the study product started on the day of stem cell mobilizing chemotherapy and continued until the end of aplasia after high dose chemotherapy, a period of about seven weeks. Thirty-three patients were evaluable for all study endpoints, while all 40 included patients were evaluable for survival endpoints. In the leukapheresis product harvested after stem cell mobilisation, increased percentages of Treg cells and plasmacytoid dendritic cells were found in patients receiving AndoSan. Also, in this group, a significant increase of serum levels of IL-1ra, IL-5, and IL-7 at the end of treatment was found. Whole genome microarray showed increased expression of immunoglobulin genes, Killer Immunoglobulin Receptor (KIR) genes, and HLA genes in the Agaricus group. Furthermore, AndoSan displayed a concentration dependent antiproliferative effect on mouse myeloma cells in vitro. There were no statistically significant differences in treatment response, overall survival, and time to new treatment. The study was registered with Clinicaltrials.gov NCT00970021.

show abstract

Inhibitory Effect ofAgaricu blazeiMurill Components on Abnormal Collagen Fiber Formation in Human Hepatocarcinoma Cells

Cited by 9 publications

References 17 publications

Dietary Natural Products for Prevention and Treatment of Liver Cancer

Dietary Natural Products for Prevention and Treatment of Liver Cancer

Effects of the Medicinal Mushroom Agaricus blazei Murill on Immunity, Infection and Cancer

Immunomodulatory Effects of theAgaricus blazeiMurrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study

Contact Info

Product

Resources

About