Inhibitory Effect ofBacillus velezensison Biofilm Formation byStreptococcus mutans

Abstract

17Streptococcus mutans plays a key role in the development of dental caries and 18 promotes the formation of oral biofilm produced by glucosyltransferases (GTFs) Dental caries is among the most common infectious diseases worldwide, and its 37 development is closely associated with physiological factors of bacteria, such as the biofilm 38 formation and glucosyltransferase production of Streptococcus mutans. Biofilms are difficult 39 to remove once they have formed due to the exopolysaccharide matrix produced by the 40 All rights reserved. No reuse allowed without permission..(which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

Inhibitory effect of Bacillus velezensis on biofilm formation by Streptococcus mutans

“…Various studies have been conducted on the anti-caries effects of microorganisms that inhibit the growth of S. mutans using treated culture medium from lactic acid bacteria and antibiotics or lytic enzymes from Bacillus spp. (12)(13)(14)(15)(16)(17). Quercitrin and deoxynojirimycin (DNJ) were recently shown to inhibit the GTF gene expression in S. mutans, which led to biofilm formation (18).…”