1996
DOI: 10.2131/jts.21.4_243
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Inhibitory effect of indomethacin on neonatal lung catabolism of prostaglandin E2: possible mechanism of the reopening of the ductus arteriosus after indomethacin therapy.

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Cited by 7 publications
(11 citation statements)
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“…They supported previous reports that re-opening of the neonatal DA induced by PGE 2 was accelerated when indomethacin was administered transplacentally [13].…”
supporting
confidence: 90%
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“…They supported previous reports that re-opening of the neonatal DA induced by PGE 2 was accelerated when indomethacin was administered transplacentally [13].…”
supporting
confidence: 90%
“…The lung 15-PGDH activity was not affected by maternal treatment of aspirin and ibuprofen. In a previous report, 15-PGDH activity decreased in newborn rats following maternal administration of indomethacin, thus, a decrease in the 15-PGDH activity was partly responsible for the increased responsiveness to PGE 2 after prenatal indomethacin treatment [13]. Comparing the present results with previous reports, increased ductal responsiveness to PGE 2 in newborns rats seems to be a common response after maternal NSAID treatment, such as indomethacin, aspirin and ibuprofen, but the catabolism of PGE 2 in the lung did not always contribute to increased ductal responsiveness to PGE 2 .…”
mentioning
confidence: 75%
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“…Re-opening of the DA after indomethacin treatment, however, is quite common, although the reason is unclear [4]. In a previous study, we found that the re-opening response of the DA induced by PGE 2 was significantly enhanced and that the neonatal lung catabolism of PGE 2 was decreased in newborn rats following maternal treatment with indomethacin [23].…”
mentioning
confidence: 90%
“…In the second experiment, 15-PGDH activity in the lung homogenate was assayed using a modified method [23] of Tsuruta and Mori [24] in newborn rats. Newborn pups were taken from the pregnant females who were administered enalapril (10 mg/kg) or captopril (150 mg/kg) as outlined in the first experiment.…”
mentioning
confidence: 99%