Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression

Win, Nan Nwe; Nakamoto, Shingo; Moriyama, Mitsuhiko; Jiang, Xia; Suganami, Akiko; Tsutsumi, Yutaka; Okamoto, Hiroaki; Shirasawa, Hiroshi

doi:10.7150/ijms.27489

Cited by 19 publications

(30 citation statements)

References 27 publications

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“…117,118 Accordingly, both PHH and HLCM-derived human hepatocytes are capable of supporting the viral lifecycle of HAV in vitro. 119,120 This evidence strongly encourages us to consider employing HLCM as an in vivo study model of HAV infection.…”

Section: Hepatitis a Virusmentioning

confidence: 93%

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

et al. 2020

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Advancement in both bioengineering and cell biology of the liver led to the establishment of the first-generation humanized liver chimeric mouse (HLCM) model in 2001. The HLCM system was initially developed to satisfy the necessity for a convenient and physiologically representative small animal model for studies of hepatitis B virus and hepatitis C virus infection. Over the last two decades, the HLCM system has substantially evolved in quality, production capacity, and utility, thereby growing its versatility beyond the study of viral hepatitis. Hence, it has been increasingly employed for a variety of applications including, but not limited to, the investigation of drug metabolism and pharmacokinetics and stem cell biology. To date, more than a dozen distinctive HLCM systems have been established, and each model system has similarities as well as unique characteristics, which are often perplexing for end-users. Thus, this review aims to summarize the history, evolution, advantages, and pitfalls of each model system with the goal of providing comprehensive information that is necessary for researchers to implement the ideal HLCM system for their purposes. Furthermore, this review article summarizes the contribution of HLCM and its derivatives to our mechanistic understanding of various human liver diseases, its potential for novel applications, and its current limitations.

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Section: Hepatitis a Virusmentioning

confidence: 93%

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

et al. 2020

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“…Japanese rice-koji miso extracts enhanced GRP78 expression and inhibited HAV HA11-1299 genotype IIIA strain replication in the human hepatocytes, Huh7 and PXB cells [ 97 ]. We investigated the effect of miso extracts on virus replication in HepG2.2.15 cells infected with the HAV HA11-1299 strain [ 73 ].…”

Section: Prevention Of Hav Infection In Patients With Chronic LIVmentioning

confidence: 99%

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Sasaki

Masuzaki

Takahashi

et al. 2020

IJMS

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Hepatitis A virus (HAV) infection occasionally leads to a critical condition in patients with or without chronic liver diseases. Acute-on-chronic liver disease includes acute-on-chronic liver failure (ACLF) and non-ACLF. In this review, we searched the literature concerning the association between HAV infection and chronic liver diseases in PubMed. Chronic liver diseases, such as metabolic associated fatty liver disease and alcoholic liver disease, coinfection with other viruses, and host genetic factors may be associated with severe hepatitis A. It is important to understand these conditions and mechanisms. There may be no etiological correlation between liver failure and HAV infection, but there is an association between the level of chronic liver damage and the severity of acute-on-chronic liver disease. While the application of an HAV vaccination is important for preventing HAV infection, the development of antivirals against HAV may be important for preventing the development of ACLF with HAV infection as an acute insult. The latter is all the more urgent given that the lives of patients with HAV infection and a chronic liver disease of another etiology may be at immediate risk.

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“…Koji, also known as Aspergillus oryzae, is a filamentous fungus employed by the Japanese to ferment certain kinds of food like soybeans, potatoes, rice and some other grains [71]. Miso is one of the by-products of the fermentation of Japanese rice by Koji.…”

Section: Adjunctive Anti-hav Natural Products 31 Japanese Rice-koji mentioning

confidence: 99%

“…Miso is one of the by-products of the fermentation of Japanese rice by Koji. Miso is conventional Japanese seasoning used for preparing miso soup, a staple Japanese cuisine [71]. Previous studies showed that Japanese miso extract increases the expression of a heat-shock protein known as glucose-regulated protein 78 (GRP78) and suppresses ultraviolet C mutagenesis [72].…”

Section: Adjunctive Anti-hav Natural Products 31 Japanese Rice-koji mentioning

confidence: 99%

“…Previous studies showed that Japanese miso extract increases the expression of a heat-shock protein known as glucose-regulated protein 78 (GRP78) and suppresses ultraviolet C mutagenesis [72]. Some researchers observed that HAV replication was retarded upon expression of GRP78 [71]; hence GRP78 has become a potential host antiviral against HAV infection [73]. Recent post-infection assay examined miso extracts obtained from Japanese rice-koji for antiviral activity against HAV, and it was shown that the miso extracts inhibited HAV replication by enhancing the expression of GRP78 in human hepatocytes (Huh7 and PXB cells) [71].…”

Section: Adjunctive Anti-hav Natural Products 31 Japanese Rice-koji mentioning

confidence: 99%

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Antiviral Natural Products against Hepatitis-A Virus

Odimegwu¹,

Ukachukwu²

2020

Hepatitis a and Other Associated Hepatobiliary Diseases

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The review on antiviral anti-hepatitis A virus agents is warranted given the importance of hepatitis A virus (HAV) as a human pathogen. Novel antiviral drugs have been sourced from natural agents and developed into products for management of viral infections. The role of purified natural products in treatment and as adjunctives in the management of HAV infections is clearly plausible. Treatments against Hepatitis A virus infection is currently limited. In this chapter, the antiviral natural products against hepatitis-A virus (HAV), their sources as well as their treatment approach and their application have been discussed. The antiviral natural products could be sourced generally from plants, herbs and animals. These natural agents have been shown to demonstrate substantial antiviral activity against HAV and could target various stages of the viral life cycle, replication, assemblage, release, as well as targeting virus-host specific interactions.

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Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression

Cited by 19 publications

References 27 publications

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

Art of Making Artificial Liver: Depicting Human Liver Biology and Diseases in Mice

Co-Occurrence of Hepatitis A Infection and Chronic Liver Disease

Antiviral Natural Products against Hepatitis-A Virus

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