Inhibitory effect of Lonicera japonica-derived exosomal miR2911 on human papilloma virus

Chi, Yuhao; Shi, Lei; Shen, Lu; He, Chong; Zha, Wei; Shan, Linlin; Shen, Yuan

doi:10.1016/j.jep.2023.116969

Cited by 5 publications

(1 citation statement)

References 58 publications

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“…Regulatory effects of exogenous miRNAs from daily diet on mammalian bodies have been a research hotspot for years. ,, cal-miR2911, a plant miRNA that is abundant in fruits and vegetables consumed in daily diet, has atypical biogenesis from 26S rRNA (rRNA) and significantly high GC content in sequence composition . Recent studies showed that miR2911 potentially targeted genes of virus and inhibited the replication of influenza A virus, human papilloma virus, coronavirus 2019, and enterovirus 71, leading to mitigation and reverse of the related symptoms. ,− If an exogenous miRNA could resist the process of food digestion and survive in the ileum with a certain amount, then its potential to enter the circulation and regulate host gene expression would be greatly increased. Given its unique sequence property and antiviral capability, stability of miR2911 under the digestive environment was comprehensively studied, as well as its effects on the composition and the diversity of gut microbiota in mice.…”

Section: Discussionmentioning

confidence: 99%

Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on Bifidobacterium in Mice

Xu,

Wang,

Zhang

et al. 2024

J. Agric. Food Chem.

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Previous studies showed that cal-miR2911, featuring an atypical biogenesis, could target genes of virus and in turn inhibit virus replication. Given its especial sequence motif and cross-kingdom potential, the stability of miR2911 under digestive environment and its impact on intestinal microbes in mice were examined. The results showed that miR2911 was of considerable stability during oral, gastric, and intestinal digestion. The coingested food matrix enhanced its stability in the gastric phase, contributing to the existence of miR2911 in mouse intestines. The survival miR2911 promoted the growth of Bif idobacterium in mice and maintained the overall composition and diversity of the gut microbiota. miR2911 specifically entered the cells of Bifidobacterium adolescentis and potentially modulated the gene expression as evidenced by the dual-luciferase assay. The current study provided evidence on the cross-kingdom communication between dietary miRNAs and gut microbes, suggesting that modulating target bacteria using miRNAs for nutritional and therapeutic ends is promising.

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Section: Discussionmentioning

confidence: 99%

Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on Bifidobacterium in Mice

Xu,

Wang,

Zhang

et al. 2024

J. Agric. Food Chem.

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The Role of Traditional Chinese Medicine in the Management of Cervical Cancer

Wu,

Zhou,

Chen

et al. 2024

Am. J. Chin. Med.

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Globally, cervical cancer poses a substantial public health challenge, with low and middle-income countries bearing the highest burden [Rajkhowa, P., D.S. Patil, S.M. Dsouza, P. Narayanan and H. Brand. Evidence on factors influencing HPV vaccine implementation in South Asia: a scoping review. Glob. Public Health 18: 2288269, 2023]. The incidence rate ranks second highest among female malignant tumors in China, following only breast cancer. The prognosis of advanced cervical cancer is extremely poor, with a 5-year progression-free survival (PFS) rate of only 15%, and the treatment of advanced recurrent or metastatic cervical cancer remains a huge challenge. An increasing amount of evidence suggests that traditional Chinese medicine (TCM) can significantly enhance sensitivity to chemotherapeutic drugs, strengthen antitumor effects, and notably improve adverse reactions associated with cancer such as fatigue and bone marrow suppression. In recent years, the therapeutic effects and mechanisms of Chinese herbal medicines, such as the Guizhi-Fuling-decoction, the compound Yangshe granule, Huangqi, and Ginseng, herbal monomers (e.g., Ginsenoside Rh2, Tanshinone IIA, and Tetrandrine), and the related extracts and compound formulations, have received extensive attention for the treatment of cervical cancer. This paper reviews the research progress of TCM in cervical cancer. In addition, we reported a case of an advanced cervical cancer patient with multiple abdominal and pelvic metastasis who initially received chemotherapy, was then treated with TCM alone, and subsequently survived for 22 years. The model of whole-process management with TCM can enable more cancer patients to obtain longer survival periods.

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Ecological niche imprints the structure and network of microbial communities in Lonicera japonica Thunb

Zhang,

Dong,

Chen

et al. 2024

Preprint

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Background and aims Plant-associated microbiomes play pivotal roles in promoting plant health, productivity, and resistance to diseases. However, the differential adaptability of microorganisms to different microenvironments in Lonicera japonica remains unclear, which hinders their application in agriculture. Methods Here, the structure and network of bacterial and fungal communities in six compartment niches (bulk soil, rhizosphere soil, root, stem, leaf, and flower) of L. japonica were explored using three host ecotypes. Results Results demonstrated that the structure and assembly of microbiomes along the soil–plant continuum were primarily governed by compartment niches rather than host ecotypes. Bacterial diversity and network complexity incrementally decreased from the soil to the root and flower; however, fungal diversity and network complexity gradually decreased from the soil to the stem but increased from the stem to the leaf and flower. The bacterial keystone taxa Proteobacteria, Pseudomonas, Pantoea, Kluyvera, and Enterobacter were dominated in endosphere samples. Meanwhile, the core fungal keystone taxa Cryptococcus, Alternaria, and Erysiphe were dominated by endosphere samples. However, Mortierella and Fusarium were dominated by rhizosphere soil. Conclusion Microbiota was mainly derived from bulk soil and then filtered in each compartment niches. This finding provides empirical evidence for host selection and soil–plant–microbiome interaction along the soil–plant continuum.

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Inhibitory effect of Lonicera japonica-derived exosomal miR2911 on human papilloma virus

Cited by 5 publications

References 58 publications

Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on Bifidobacterium in Mice

Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on Bifidobacterium in Mice

The Role of Traditional Chinese Medicine in the Management of Cervical Cancer

Ecological niche imprints the structure and network of microbial communities in Lonicera japonica Thunb

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