Inhibitory effect of mesna and 5-fluorouracil on propylene glycol-induced cholesteatoma in rats

Kökten, Numan; Tüysüz, Ozan; Zenginkinet, Tülay; Hanege, Fatih Mehmet; Kalcıoğlu, M. Tayyar

doi:10.14639/0392-100x-n1392

Cited by 4 publications

(4 citation statements)

References 22 publications

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“… 12 , 13 However, more recent studies have shown that 100% concentrated MESNA without dilution is more effective in controlling cholesteatoma. 7 , 8 Kokten et al 6 used a 100% concentration of MESNA and reported that it inhibited the formation of cholesteatoma in their study investigating its effectiveness on cholesteatoma.…”

Section: Discussionmentioning

confidence: 99%

“…In one of these studies, MESNA was shown to be highly effective in preventing the formation of propylene glycol-induced cholesteatoma in rats. 6 Sodium 2-mercaptoethanesulfonate has been proven by experimental studies to be non-ototoxic, and in some clinics, such as ours, it is used in the surgical treatment of cholesteatoma. It has been reported in short-term follow-up studies that MESNA is effective enough to reduce residual cholesteatoma.…”

Section: Introductionmentioning

confidence: 99%

“… 7 Similarly, Kokten et al conducted another study using a 100% concentration and found no ototoxic effects. 6 Another aspect to consider with the increasing popularity of MESNA use in otologic surgery is its potential toxic effect on the facial nerve. In a study by Baklacı et al, they investigated the effects of 25% and 100% concentrations of MESNA on the facial nerve and reported that MESNA had no toxic effect on the facial nerve.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-Term Results of Sodium 2-Mercaptoethane Sulfonate Usage on Cholesteatoma Surgery

Celik,

Yalcın,

Kılıc

et al. 2024

JIAO

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Long-Term Results of Sodium 2-Mercaptoethane Sulfonate Usage on Cholesteatoma Surgery

Celik,

Yalcın,

Kılıc

et al. 2024

JIAO

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“…Reports from dermatological applications of 5-FU for malignant tumors have indicated that erythema and erosion are the most commonly reported adverse effects [16]. Recently, the combination of 5-FU with sodium 2-mercaptoethanesulfonate (MESNA), a synthetic sulfur compound that disrupts epithelial disulfide bonds, has shown promise in rat studies for cholesteatoma treatment [17]. Interestingly, MESNA has already been utilized as an adjunct in cholesteatoma surgery [18], thereby suggesting that combined therapy with 5-FU and MESNA may hold potential as a future ambulatory care option.…”

Section: Discussionmentioning

confidence: 99%

A Novel Strategy for Conservative Management of External Auditory Canal Cholesteatoma: Employing 5-Fluorouracil in Ambulatory Care for Select Patients

Niwa,

Utsunomiya,

Kuyama

et al. 2023

AOHNS

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Objective: This research illuminated the exploration of an alternative path in the therapeutic landscape of cholesteatoma, an abnormal growth in the ear that commonly necessitates surgical resolution. This study was motivated by the reality that not every patient is inclined, or has the capacity, to pursue surgical intervention due to personal reservations or geographic limitations. Consequently, our study highlights the utilization of 5-fluorouracil (5-FU), a compound acclaimed for its efficacy in oncology chemotherapy, as a potential substitute for invasive measures in cholesteatoma treatment. The main objective was to critically examine the non-invasive approach to managing cholesteatoma through 5-FU administration in ambulatory care environments.Methods: This investigation was built upon a case series study, meticulously assessing the clinical outcomes of patients who underwent treatment for cholesteatoma in an ambulatory care facility. Between November 2007 and November 2020, 15 ears of 14 patients were evaluated for cholesteatoma in the external auditory canal, attic area, or previously operated mastoid cavity. After thorough ear cleaning and debris extraction, the obtained tissues were examined pathologically. The treatment regimen consisted of a monthly application of roughly 0.3 mg of 5% 5-FU cream (Kyowa Kirin) to the afflicted region. The efficacy of this therapy was gauged after a one-month duration using Takahashi's criteria, with the cholesteatoma's status meticulously documented monthly.Results: Fourteen patients were monitored (average age of 78 years; 71% female) at our ambulatory facility for cholesteatoma diagnosis. Left ear cholesteatoma was diagnosed in nine patients (60%), right ear in four (27%), and bilateral in one (13%). Reported symptoms included hearing impairment (33%), otorrhea and otalgia (17% each), ear fullness (13%), ear discomfort (11%), and bleeding (6%). The cholesteatoma's location was distributed as follows: external auditory canal (67%), attic (20%), and mastoid cavities (13%). Clinical observations revealed 87% of patients with epithelial debris, and 13% with granulation and epithelial debris. Pathological examinations confirmed the diagnosis of cholesteatoma. No surgical interventions were performed. The clinical appraisals revealed 87% positive results, 13% satisfactory outcomes, and no cases of poor outcomes. Conclusion:Our findings advocate the feasibility of conservative, non-surgical cholesteatoma treatment with topical 5-FU cream within an ambulatory care framework. This approach might serve as an effective alternative for certain patient demographics, including the elderly and individuals residing in remote areas where access to specialized medical services is limited. The adoption of such a treatment modality could potentially enhance cholesteatoma management, leading to improved quality of life for patients.

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Osteopontin-driven partial epithelial-mesenchymal transition governs the development of middle ear cholesteatoma

Zeng,

Xie,

et al. 2024

Cell Cycle

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Inhibitory effect of mesna and 5-fluorouracil on propylene glycol-induced cholesteatoma in rats

Cited by 4 publications

References 22 publications

Long-Term Results of Sodium 2-Mercaptoethane Sulfonate Usage on Cholesteatoma Surgery

Long-Term Results of Sodium 2-Mercaptoethane Sulfonate Usage on Cholesteatoma Surgery

A Novel Strategy for Conservative Management of External Auditory Canal Cholesteatoma: Employing 5-Fluorouracil in Ambulatory Care for Select Patients

Osteopontin-driven partial epithelial-mesenchymal transition governs the development of middle ear cholesteatoma

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