Inhibitory effect of milk fat on milk secretion in the mouse: a re‐examination

Peaker, M.; Taylor, Emma

doi:10.1113/expphysiol.1994.sp003788

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Heesom et al (1992) suggested that FIL may regulate lactose and casein synthesis, whereas fat synthesis may be regulated by a negative feedback mechanism involving medium chain fatty acids. To test this hypothesis, Peaker and Taylor (1994) investigated the effect of milk fat on litter weight gain in mice. Intraperitoneal injection of whole milk (which contains milk fat globules) into lactating mice inhibited litter growth, whereas skim milk (which was supposed to contain FIL) or fractions of milk fat globules alone had no effect.…”

Section: Local Regulation Of Milk Production and Mammary Functionmentioning

confidence: 99%

TRIENNIAL LACTATION SYMPOSIUM: A local affair: How the mammary gland adapts to changes in milking frequency1,2

Wall

McFadden

2012

Journal of Animal Science

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Regular removal of milk from the mammary gland is critical to maintaining milk secretion. Early studies in rodents demonstrated that changes in milking frequency influenced mammary blood flow, as well as mammary cell number and activity. Later studies in ruminants confirmed those observations and that the response was regulated locally within the mammary gland. In addition, it was discovered that increased milking frequency (IMF) during early lactation stimulated an increase in milk production that partially persisted through late lactation, indicating long-term effects on mammary function. The local mechanisms regulating the mammary response to IMF are poorly understood, although several have been proposed. To gain insight into the mechanisms underlying the mammary response to IMF, and to identify genes associated with the response, we used a functional genomics approach and conducted experiments on dairy cows exposed to unilateral frequent milking (UFM; twice daily milking (2X) of the left udder half, four-times daily milking (4X) of the right udder half). Across multiple experiments, we were unable to detect an effect of UFM on mammary cell proliferation or apoptosis. We have, however, identified distinct transcriptional signatures associated with the mammary response to milk removal and to UFM during early lactation. Sequential sampling of mammary tissue revealed that when UFM was imposed during early lactation, at least two sets of genes were coordinately regulated with changes in differential milk production of 4X vs. 2X udder halves. Moreover, some genes were persistently differentially expressed in 4X vs. 2X udder halves after UFM and were associated with the persistent increase in milk yield. We conclude that a coordinated transcriptional response is associated with the increase in milk yield elicited by IMF during early lactation, and that the two sets of differentially expressed genes may be a marker for the autocrine up-regulation of milk production. Moreover, we propose that we have identified a novel form of imprinting associated with persistent alteration of mammary function, which we term 'lactational imprinting.”

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Section: Local Regulation Of Milk Production and Mammary Functionmentioning

confidence: 99%

TRIENNIAL LACTATION SYMPOSIUM: A local affair: How the mammary gland adapts to changes in milking frequency1,2

Wall

McFadden

2012

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Heesom et al (1992) suggested that FIL may regulate lactose and casein synthesis, whereas fat synthesis may be regulated by a negative feedback mechanism involving medium chain fatty acids. To test this hypothesis, Peaker and Taylor (1994) investigated the effect of milk fat on litter weight gain in mice. Infusion of whole milk (which contains milk fat globules) into the mammary glands of lactating mice inhibited litter growth, whereas skim milk (which contains FIL) or fractions of milk fat globules alone had no effect.…”

Section: Negative Feedback On Milk Fat Synthesismentioning

confidence: 99%