Inhibitory Effect of Mispyric Acid on Mammalian DNA Polymerases

Synthetic Studies on Kohamaic Acids: Synthesis of Structurally Simplified Analogs of Kohamaic Acid A

“…Inspired by the unique structure and the abovementioned potential of KA-A as a new lead, we initiated synthetic studies on KA-A in continuation of our work on the synthesis of pol inhibitor. 3,4) We decided on the evaluation of structure-activity relationships (SAR) as the foremost task of this project, because a basic understanding of SAR is essential to the development of new drug candidates. In this communication, we report the synthesis of a series of structurally simplified analogs of KA-A.…”