Inhibitory effect of okadaic acid on noradrenaline exocytosis from guinea-pig vas deferens

Ogawa, Shusuke; Katsuragi, Takeshi; Matsuo, Katsuichi; Furukawa, Tatsuo

doi:10.1016/0304-3940(94)90310-7

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…A number of early studies suggested that okadaic acid treatment of synaptosomes, neuromuscular junctions or cultured cells resulted in increased release of neurotransmitters including glutamate, GABA (γ -aminobutyric acid) and acetylcholine [257][258][259][260][261]. However, the most recent studies indicate inhibition of neurotransmitter release from synaptosomes or cells treated with either okadaic acid or calyculin A ( [262,263], but see [263a]; [264][265][266]). Because of the relatively high concentrations of PP1 and PP2A in neuronal tissue, concentrations of okadaic acid much greater than in vitro IC 50 concentrations are typically required to induce a response.…”

Section: Neuronal Exocytosismentioning

confidence: 99%

The role of serine/threonine protein phosphatases in exocytosis

Sim

Baldwin

Rostas

et al. 2003

Biochemical Journal

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Modulation of exocytosis is integral to the regulation of cellular signalling, and a variety of disorders (such as epilepsy, hypertension, diabetes and asthma) are closely associated with pathological modulation of exocytosis. Emerging evidence points to protein phosphatases as key regulators of exocytosis in many cells and, therefore, as potential targets for the design of novel therapies to treat these diseases. Diverse yet exquisite regulatory mechanisms have evolved to direct the specificity of these enzymes in controlling particular cell processes, and functionally driven studies have demonstrated differential regulation of exocytosis by individual protein phosphatases. This Review discusses the evidence for the regulation of exocytosis by protein phosphatases in three major secretory systems, (1) mast cells, in which the regulation of exocytosis of inflammatory mediators plays a major role in the respiratory response to antigens, (2) insulin-secreting cells in which regulation of exocytosis is essential for metabolic control, and (3) neurons, in which regulation of exocytosis is perhaps the most complex and is essential for effective neurotransmission.

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