Inhibitory effect of particulate matter on toll-like receptor 9 stimulated dendritic cells by downregulating mitogen-activated protein kinase and NF-κB pathway

Arooj, Madeeha; Ali, İrshad; Kang, Hee Kyoung; Hyun, Jin Won; Koh, Young‐Sang

doi:10.1080/15287394.2020.1756018

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…And autophagy deficiency enhanced the expression of Nrf2, which can inhibit the inflammatory response as well as the levels of IL-8, IL-6 and TNF-α induced by PM 2.5 stimulation [ 192 ]. In CpG-DNA (TLR9 ligand)-stimulated dendritic cells, PM 2.5 significantly reduced the levels of TNF-α, IL-6 and IL-12 p40, which might be related to the inhibition of NF-κB and MAPK signaling pathways [ 193 ]. It has been suggested that PM 2.5 and formaldehyde might induce hematopoietic toxicity by reducing the expression of blood cells, myeloid progenitor cells (MPCs) and hematopoietic growth factors.…”

Section: The Effects and Mechanisms Of Pm On Neurologic Systemmentioning

confidence: 99%

A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence

Sun

et al. 2022

Part Fibre Toxicol

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The impacts of air pollution on public health have become a great concern worldwide. Ambient particulate matter (PM) is a major air pollution that comprises a heterogeneous mixture of different particle sizes and chemical components. The chemical composition and physicochemical properties of PM change with space and time, which may cause different impairments. However, the mechanisms of the adverse effects of PM on various systems have not been fully elucidated and systematically integrated. The Adverse Outcome Pathway (AOP) framework was used to comprehensively illustrate the molecular mechanism of adverse effects of PM and its components, so as to clarify the causal mechanistic relationships of PM-triggered toxicity on various systems. The main conclusions and new insights of the correlation between public health and PM were discussed, especially at low concentrations, which points out the direction for further research in the future. With the deepening of the study on its toxicity mechanism, it was found that PM can still induce adverse health effects with low-dose exposure. And the recommended Air Quality Guideline level of PM2.5 was adjusted to 5 μg/m3 by World Health Organization, which meant that deeper and more complex mechanisms needed to be explored. Traditionally, oxidative stress, inflammation, autophagy and apoptosis were considered the main mechanisms of harmful effects of PM. However, recent studies have identified several emerging mechanisms involved in the toxicity of PM, including pyroptosis, ferroptosis and epigenetic modifications. This review summarized the comprehensive evidence on the health effects of PM and the chemical components of it, as well as the combined toxicity of PM with other air pollutants. Based on the AOP Wiki and the mechanisms of PM-induced toxicity at different levels, we first constructed the PM-related AOP frameworks on various systems. Graphical Abstract

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Section: The Effects and Mechanisms Of Pm On Neurologic Systemmentioning

confidence: 99%