Inhibitory effect of phenolic extract from squirting cucumber (<i>Ecballium elaterium</i> (L.) A. Rich) seed oil on integrin-mediated cell adhesion, migration and angiogenesis

Touihri-Barakati, Imen; Kallech-Ziri, Olfa; Morjen, Maram; Marrakchi, Naziha; Luis, José; Hosni, Karim

doi:10.1039/d2ra02593k

Cited by 7 publications

(2 citation statements)

References 55 publications

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“…Together, these results indicate that the lower-dose treatment with OLE could influence invasive properties of trophoblast cells through stimulating expression of integrin subunits which mediate this process. So far, the influence of flavonoids and secoiridoids as natural integrin antagonists has been shown in cancer cells, where they effectively modulated a wide range of integrins, thereby inhibiting the key cancer hallmarks (adhesion, migration, proliferation, invasion, angiogenesis and metastasis) [ 48 ]. In contrast, within non-cancer cells such as trophoblast HTR-8/SVneo cells, the effects of flavonoids were associated with an increase in the invasive capacity [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

Pirković,

Jovanović Krivokuća,

Vilotić

et al. 2023

IJMS

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Successful pregnancy establishment requires highly synchronized cross talk between the invasive trophoblast cells and the receptive maternal endometrium. Any disturbances in this tightly regulated process may lead to pregnancy complications. Local factors such as nutrients, hormones, cytokines and reactive oxygen species modulate the invasion of extravillous trophoblasts through critical signaling cascades. Epidemiological studies strongly indicate that a Mediterranean diet can significantly impact molecular pathways during placentation. Therefore, the aim of the current study was to examine whether oleuropein (OLE), one of the main compounds of the Mediterranean diet, may influence trophoblast cell adhesion and migration, as well as the expression of invasion-associated molecular markers and inflammatory pathways fostering these processes. HTR-8/SVneo cells were incubated with OLE at selected concentrations of 10 and 100 µM for 24 h. Results showed that OLE did not affect trophoblast cell viability, proliferation and adhesion after 24 h in in vitro treatment. The mRNA expression of integrin subunits α1, α5 and β1, as well as matrix-degrading enzymes MMP-2 and -9, was significantly increased after treatment with 10 µM OLE. Furthermore, OLE at a concentration of 10 µM significantly increased the protein expression of integrin subunits α1 and β1. Also, OLE inhibited the activation of JNK and reduced the protein expression of COX-2. Finally, a lower concentration of OLE 10 µM significantly stimulated migration of HTR-8/SVneo cells. In conclusion, the obtained results demonstrate the effects of OLE on the function of trophoblast cells by promoting cell migration and stimulating the expression of invasion markers. As suggested from results, these effects may be mediated via inhibition of the JNK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

Pirković,

Jovanović Krivokuća,

Vilotić

et al. 2023

IJMS

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“…Furthermore, the consumption of certain naturally derived dietary products at high levels may decrease the likelihood of tumor recurrence and enhance survival in breast cancer patients [73]. Many nutritional natural products found in the Mediterranean area, including pomegranate [74,75], edible mushrooms [76,77], marine algae [78,79], curcumin [80,81], whole-grain cereals [82,83], citrus fruit [84,85], grapes [86,87], and cucumber [88,89], have been shown in experimental studies to disrupt the development and progression of cancer via the application of anticancer or antineoplastic activity.…”

Section: Fruits Vegetables and Plant-based Foodsmentioning

confidence: 99%

The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns

Tsai

Hsu

et al. 2023

Nutrients

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Breast cancer is a significant public health problem globally and prevention strategies have become of great interest as its incidence rises. Exploring the connection between dietary patterns and the reduction of breast cancer risk is considered a promising approach. High levels of fiber, phytochemicals, a good antioxidant profile, and a composition of advantageous fatty acids are characteristics of healthy dietary programs such as the Mediterranean diet. This review summarized and discussed the active compounds that are considered important in preventing breast cancer, including dietary components from recent related reports. These include polyunsaturated fatty acids, fiber, phytochemicals, and alcohol. Although the exact mechanism for preventing breast cancer using these dietary factors is not well understood, the combination of all the elements in a healthy diet plays a role in reducing breast cancer risk. Considering the elevated probability of breast cancer relapse and mortality, it is crucial to investigate the correlation between a nutritious dietary pattern and breast cancer, while identifying bioactive components that have the potential to mitigate the risk of breast cancer incidence.

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Anticancer Properties of Different Varieties of Date Palm (Phoenix dactylifera L.) Leaf Extracts in Human Tumor Cells: a Comparative Study

Chakroun,

Morjen,

Mabrouk

et al. 2024

Plant Foods Hum Nutr

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Inhibitory effect of phenolic extract from squirting cucumber (Ecballium elaterium (L.) A. Rich) seed oil on integrin-mediated cell adhesion, migration and angiogenesis

Abstract: Phenolic extract from Ecballium elaterium inhibits integrin-mediated adhesion and migration, and hinders VGEF-induced angiogenesis.

Cited by 7 publications

References 55 publications

Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers

The Risk of Breast Cancer between Western and Mediterranean Dietary Patterns

Anticancer Properties of Different Varieties of Date Palm (Phoenix dactylifera L.) Leaf Extracts in Human Tumor Cells: a Comparative Study

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