Inhibitory effect of platinum (II) complex of curcumin on non-small cell lung cancer via the PI3K-AKT pathway

Abstract

Purpose: To study the effect of platinum (II) complex of curcumin (PCC) on non-small cell lung cancer (NSCLC) using human NSCLC cell line A549. Methods: The anti-proliferative and apoptotic effects of PCC against NSCLC were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Annexin V-FITC/propidium iodide double staining, quantitative real-time polymerase chain reaction (qRT-PCR), and western blot assays. Results: First, MTT assay and Annexin V-FITC/propidium iodide double staining results revealed that PCC possesses strong anti-cancer potency and high safety, when compared with cisplatin. Western blotting and qRT-PCR results showed that PCC inhibited the viability of NSCLC cells, decreased the expressions of PI3K, VEGF, AKT and Bcl-2, and upregulated the expression of PTEN. Conclusion: These results indicate that PCC promotes apoptosis in A549 cells via PTEN/PI3K/AKT signaling pathways.

Isoginkgetin inhibits lung cancer cell progression through miR-27a-5p/APEX1 axis

“…Many miRNAs with abnormal expressions in lung cancer participate in the occurrence and spread of lung cancer. It is well known that miRNA is an important target of traditional Chinese medicine [16]. High throughput sequencing has revealed several abnormally expressed miRNAs in curcumintreated lung cancer cells [16].…”

“…It is well known that miRNA is an important target of traditional Chinese medicine [16]. High throughput sequencing has revealed several abnormally expressed miRNAs in curcumintreated lung cancer cells [16]. Therefore, the development of drugs targeting miRNAs is promising for the treatment of lung cancer through regulation of miRNA expressions.…”