Inhibitory Effect of Polyphenol-Enriched Apple Extracts on Mast Cell Degranulationin VitroTargeting the Binding between IgE and FcεRI

Tokura, Tomoko; Nakano, Nobuhiro; Ito, Toshifumi; Matsuda, Hironori; Nagasako-Akazome, Yoko; Kanda, Tomomasa; Ikeda, Mitsuo; Okumura, Ko; Ogawa, Hideoki; Nishiyama, Chiharu

doi:10.1271/bbb.69.1974

Cited by 75 publications

(55 citation statements)

References 11 publications

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“…The action of tannic acid is specific to CXCL12/ CXCR4 given that other chemokines/chemoattractants are not effected by this tannin preparation (70). Furthermore, apple tannins block Fc R1/IgE binding (55) and prevent epidermal growth factor signaling, presumably through physically blocking the receptor (57). Similar polyphenols from tea bind CD11b on monocytes, which we recently found for APP as well (43).…”

Section: Discussionmentioning

confidence: 52%

“…Interestingly, these illnesses are commonly associated with ␥␦ T cell regulatory activities (7,(51)(52)(53)(54), suggesting the described immunostimulatory properties of the Cat's Claw plant could be partially due to the activation of ␥␦ T cells. Preparations containing the apple-condensed tannins we described are also recognized for similar immunostimulatory properties (49,(55)(56)(57). These observations on the immunological effects of Cat's Claw and apple tannins support the prospect for condensed tannins to be used as a therapy to increase ␥␦ T cell function in innate immunity and wound healing.…”

Section: Discussionmentioning

confidence: 55%

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Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Holderness

Jackiw

Kimmel

et al. 2007

The Journal of Immunology

118

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γδ T cells are innate immune cells that participate in host responses against many pathogens and cancers. Recently, phosphoantigen-based drugs, capable of expanding γδ T cells in vivo, entered clinical trials with the goal of enhancing innate immune system functions. Potential shortcomings of these drugs include the induction of nonresponsiveness upon repeated use and the expansion of only the Vδ2 subset of human γδ T cells. Vδ1 T cells, the major tissue subset, are unaffected by phosphoantigen agonists. Using FACS-based assays, we screened primary bovine cells for novel γδ T cell agonists with activities not encompassed by the current treatments in an effort to realize the full therapeutic potential of γδ T cells. We identified γδ T cell agonists derived from the condensed tannin fractions of Uncaria tomentosa (Cat’s Claw) and Malus domestica (apple). Based on superior potency, the apple extract was selected for detailed analyses on human cells. The apple extract was a potent agonist for both human Vδ1 and Vδ2 T cells and NK cells. Additionally, the extract greatly enhanced phosphoantigen-induced γδ T cell expansion. Our analyses suggest that a tannin-based drug may complement the phosphoantigen-based drugs, thereby enhancing the therapeutic potential of γδ T cells.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 55%

Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Holderness

Jackiw

Kimmel

et al. 2007

The Journal of Immunology

118

View full text Add to dashboard Cite

show abstract

“…Cocoa and cocoa products that are abundant in West "frica as well as green and black teas are rich in various catechins that belong to a group of lavanols. "ll citrus fruits and juices are also good sources of lavanones [59,60].…”

Section: Sources Of Polyphenolsmentioning

confidence: 99%

Wound Care: Traditional African Medicine Approach

Builders¹,

Builders²

2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Wound care represents a major health burden in "frica. The types and causes of wounds in "frica are numerousɤ however, the interventions to these injuries are easily accessed in hospitals in the urban cities, while in most rural communities, the primary source of interventions is traditional medicine (TMɮ. In recent times, there are incidences of preferences to the use of TM in the management of especially challenging wounds even when conventional interventions are available. In some "frican communities, there are incidences of quasi integration of conventional and traditional "frican medicine (T"Mɮ in wound care. In the typical traditional "frican approach to wound care, diverse practices such as the use of herbal medicine, divination, and other physical interventions are common. There appears to be a favorable future for wound management using T"M with the increasing popularity due to various airmative reasons other than poverty. The recognition, patronage, and uses of T"M for wound care as an alternative or complimentary to the conventional approach is expected to continue, hence, the need for the diferent regional governments in consonance with the WHO to promote the standardization, regulation, and other factors that will assure the safety and eicacy of the various practices and products of T"M.

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“…In this study, demonstration of the feasibility of producing processed foods from unripe apple starch using koji mold is expected. Although the functions of polyphenols in unripe apples have been extensively studied (Kanda et al, 1998, Tokura et al, 2005, research on the utilization of starch from unripe apples is scarce. Identification of the ability of koji mold to utilize starch in unripe apples might lead to the effective utilization of this unused resource.…”

Section: Introductionmentioning

confidence: 99%

Increase in the Activity of α-amylase Produced by Aspergillus oryzae in Dried Unripe Apple Pulp Culture on Addition of NaNO3 and MgSO4

Izawa

Kamata

Kuwano

2016

FSTR

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Unripe apples contain large quantities of starch and represent an unused organic resource. Starch hydrolysis in unripe apples may provide an effective method to utilize this resource as a food material. Aspergillus oryzae can be grown using unripe apples. However, the activity level of α-amylase produced by A. oryzae grown in dried unripe apple pulp remains unconfirmed. Therefore, we here examined various culture conditions that might increase this α-amylase activity. Our results suggested that for culturing A. oryzae in dried unripe apple pulp using the shaking culture method, the addition of NaNO 3 and MgSO 4 ·7H 2 O as nitrogen and magnesium and/or sulfur sources, respectively, was essential. Thus, α-amylase production by A. oryzae required high oxygen levels and additional nitrogen and magnesium and/or sulfur sources, both of which occur in low quantities in dried unripe apple pulp.

show abstract

Inhibitory Effect of Polyphenol-Enriched Apple Extracts on Mast Cell Degranulationin VitroTargeting the Binding between IgE and FcεRI

Cited by 75 publications

References 11 publications

Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Select Plant Tannins Induce IL-2Rα Up-Regulation and Augment Cell Division in γδ T Cells

Wound Care: Traditional African Medicine Approach

Increase in the Activity of α-amylase Produced by <i>Aspergillus oryzae</i> in Dried Unripe Apple Pulp Culture on Addition of NaNO<sub>3</sub> and MgSO<sub>4</sub>

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