Inhibitory effect of pomegranate ( Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli

Pagliarulo, Caterina; Vito, Valentina De; Picariello, Gianluca; Colicchio, Roberta; Pastore, Gabiria; Salvatore, Paola; Volpe, Maria Grazia

doi:10.1016/j.foodchem.2015.06.028

Cited by 149 publications

(120 citation statements)

References 36 publications

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“…The extraction yield of MPE was 35.4 g/100 g on a dry weight basis (Table ). This value is very much around values reported by Li et al (); Shiban Al‐Otaibi and Al‐Zoreky () and Pagliarulo et al () who reported that methanol extract yield of pomegranate peel were 31.5%, 45.4%, and 49.9%, respectively. Total phenolic compounds (TPC) was 188.9 mg GAE/g extract residue.…”

Section: Resultssupporting

confidence: 86%

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

El-Hadary

Ramadan

2019

J Food Biochem

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This work is aimed to evaluate phenolics composition, and in vitro antioxidant activities of hydro‐methanol pomegranate (Punica granatum L.) peel extract (MPE). In addition, the antihyperglycemic, hypolipidemic, and hepatoprotective effect of MPE in Wister albino rats was compared with standard drugs (glibenclamide and atorvastatin). Total phenolic content and total flavonoid contents in MPE (mg g−1) accounted for 188.9 as GAE and 13.95 as QE, respectively. Phenolic and flavonoids compounds in MPE analyzed by HPLC and revealed the presence of 23 phenolic compounds and 20 flavonoid compounds. For in vivo experiment, 56 rats were distributed into 8 groups. Group 1 was the normal control, while group 2 contained rats orally administrated with 200 mg kg−1 MPE daily. Group 3 contained diabetic rats (induced with a single dose of 100 mg/kg b.w. alloxan). Group 4 contained diabetic rats administered daily with 200 mg/kg MPE. Group 5 contained diabetic rats administered orally with a glibenclamide (standard drug for diabetic) at 10 mg/kg daily. Group 6 fed with high fat diet (HFD). Group 7 contained HFD‐rats administered orally with 200 mg/kg MPE daily. Group 8 contained HFD‐rats administered orally with atorvastatin (used to lower LDL‐cholesterol (LDL‐C) and fats and to raise HDL‐cholesterol (HDL‐C) in the blood) at 10 mg/kg daily. The study lasted for 56 days. Administration with MPE 200 mg/kg to both diabetic and hyperlipidemic rats significantly decreased blood glucose, HbA1c, total lipid, total cholesterol, LDL‐C, and very low density lipoprotein cholesterol levels, while increased high density lipoprotein cholesterol levels, as well as improved liver and kidney functions, compared with glibenclamide and atorvastatin effects. Practical applications Pomegranate peel, constituted about 50% of fruit fresh weight, is rich in bioactive compounds with potent health‐promoting activities. The results of the current study stated that MPE is rich in phenolics and flavonoids with powerful antioxidant potential. In addition, MPE showed antihyperglycemic and antihyperlipidemic activities due to the strong antiradical action via its antioxidant compounds. MPE enhanced liver and kidney functions when compared to standard drugs in diabetic and hyperlipidemic rats. MPC could be used as a natural material to develop diabetic and hyperlipidemic drugs.

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Section: Resultssupporting

confidence: 86%

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

El-Hadary

Ramadan

2019

J Food Biochem

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“…Pomegranate pomace includes many bioactive substances such as tannins, catechins, anthocyanins, gallic acid and ellagic acids (Pagliarulo et al, 2016). Among these compounds, tannins comprise approximately 25% of pomegranate peel (Voravuthikunchai et al, 2005), and ellagi-tannins have been reported to inhibit pathogenic bacteria, especially gram-positive bacteria such as L. monocytogenes (Sadeghian et al, 2011;Gyawali & Ibrahim, 2014).…”

Section: Resultsmentioning

confidence: 99%

Effect of pomegranate (Punica granatum) pomace extract as a washing agent on the inactivation of Listeria monocytogenes inoculated on fresh produce

Kang

Song

2017

Int J of Food Sci Tech

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Summary Pomegranate pomace extract (PPE) was used as a substitute to chlorinated water for washing of fresh produce. PPE contained punicalagins and ellagic acids, and it had a good inhibitory effect against Listeria monocytogenes based on the results of disc diffusion test and time‐kill assay. Red chard, beet, chicon and red mustard leaves were treated with 7 mg mL−1 PPE as a washing solution to inactivate L. monocytogenes inoculated on fresh produce and compared with 0.05 mg mL−1 NaOCl treatment. After the treatment, L. monocytogenes population on the four leafy vegetables was reduced by 1.96–2.97 log CFU g−1 compared to that on nontreated samples. The reductions in L. monocytogenes after PPE treatment were higher than those observed after NaOCl treatment. Further, the PPE treatment did not affect the surface colour of all fresh produce applied in this study. Thus, PPE can be used as an effective antimicrobial washing agent of fresh produce.

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“…The total polyphenols content of DEX-RA conjugates was evaluated by performing the Folin-Ciocalteau colorimetric assay with slight modifications [30]. For this purpose, all the tested items were previously diluted in distilled water (4% v/v).…”

Section: Folin-ciocalteu Assaymentioning

confidence: 99%

Safety and Efficacy of Dextran-Rosmarinic Acid Conjugates as Innovative Polymeric Antioxidants in Skin Whitening: What Is the Evidence?

et al. 2017

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Background: Melanins are high molecular weight pigments responsible for the mammalian skin and hair colour and play a key role in skin protection from UV radiation; however, their overproduction and excessive accumulation lead to pigmentation problems including melasma, freckles, uneven colouring, and age spots. Therefore, the modulation of melanin synthesis represents a critical issue in medicine and cosmetology. In the present study, an innovative polymeric antioxidant to be used as skin whitening agent is developed by the conjugation of dextran with rosmarinic acid. Methods: Dextran-rosmarinic acid conjugates (DEX-RA) were synthesized in a one-pot method starting from Origanum vulgare aqueous leaf extract and dextran. The total polyphenol content and the antioxidant activity were assessed by Folin-Ciocalteau assay and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and bleaching tests, respectively. The efficacy of DEX-RA was evaluated by inhibition of tyrosinase activity, in vitro diffusion and stability studies and in vivo studies. The biocompatibility of the conjugates was investigated by 3-[4,5-Dimethylthiaoly]-2,5-diphenyltetrazoliumbromide (MTT) and EPISKIN™ model. Results: Efficacy and safety studies confirmed the antioxidant and tyrosinase inhibitory activities and the biocompatibility of the synthesized conjugates. Conclusion: The polymeric conjugates, comparing to the free antioxidant, show a long-lasting efficacy combined to an enhanced stability resulting in an improved performance of the cosmetic formulations prepared using this innovative whitening agent as a bioactive ingredient.

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Inhibitory effect of pomegranate ( Punica granatum L.) polyphenol extracts on the bacterial growth and survival of clinical isolates of pathogenic Staphylococcus aureus and Escherichia coli

Cited by 149 publications

References 36 publications

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

Phenolic profiles, antihyperglycemic, antihyperlipidemic, and antioxidant properties of pomegranate (Punica granatum) peel extract

Effect of pomegranate (Punica granatum) pomace extract as a washing agent on the inactivation of Listeria monocytogenes inoculated on fresh produce

Safety and Efficacy of Dextran-Rosmarinic Acid Conjugates as Innovative Polymeric Antioxidants in Skin Whitening: What Is the Evidence?

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