Inhibitory effect of quercetin-3-O-α-rhamnoside, p-coumaric acid, phloridzin and 4-O-β-glucopyranosyl-cis-coumaric acid on rats liver microsomes cytochrome P450 enzyme activities

Ma, Changyang; Liu, Cunyu; Ren, Mengjie; Xi, Xuefeng

doi:10.1016/j.fct.2022.113583

Cited by 4 publications

(1 citation statement)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 Quercetin also has shown multiple biological activities such as antidiabetic and anti-inflammatory effects. [25][26][27][28] Recent advances in the health benefits of quercetin, including its regulatory role in metabolic syndrome, have been summarized by our previous work. 29 Fig.…”

Section: Introductionmentioning

confidence: 99%

Quercetin ameliorates hepatic fat accumulation in high-fat diet-induced obese mice via PPARs

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Quercetin ameliorates hepatic fat accumulation in high-fat diet-induced obese mice via PPARs

et al. 2023

View full text Add to dashboard Cite

show abstract

Widely targeted metabolomics reveal the distribution of primary and secondary metabolites in pomegranate fruit

Chen,

Liu,

Zhu

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

The pomegranate fruit is valued for its nutritional and medicinal properties, and the composition and content of primary and secondary metabolites are the main factors impacting its nutritional and medicinal properties. However, a deep understanding of metabolites in different parts of fruit is still lacking. Here, the peel, aril, and seed of mature pomegranate fruits were analyzed separately to compare metabolic component differences using UPLC/MS–MS. A total of 858 metabolites belonging to 11 classes were identified, of which flavonoids, such as delphinidin‐3‐O‐glucoside and cyanidin‐3‐O‐glucoside; tannins, such as ellagic acid and punicalin; and terpenoids, such as corosolic acid and madasiatic acid, were upregulated in the peel. Lipids, such as punicic acid, methyl linolenate, and linoleic acid; alkaloids, such as indole and choline; nucleotides and derivatives mainly including 2‐deoxyribose‐1‐phosphate and 9‐(arabinosyl)‐hypoxanthine, were upregulated in seeds. Phenolic acids, such as 1‐O‐galloyl‐4,6‐(S)‐HHDP‐β‐D‐glucose and 1,7‐di‐O‐galloyl‐D‐sedoheptulose, and flavonoids, such as cyanidin‐3‐O‐glucoside, cyanidin‐3‐O‐(2″‐O‐xylosyl) galactoside, and delphinidin‐3‐O‐glucoside, were upregulated in aril. The flavone and flavonol biosynthesis (ko00944) pathways were significantly enriched between the peel and seed, as were the anthocyanin biosynthesis (ko00944) pathways between the aril and seed and the flavonoid biosynthesis (ko00941) pathways between the peel and aril. Additionally, functional antioxidants, such as 10,16‐dihydroxypalmitic acid, 3‐O‐methylellagic acid, and 3,3’‐O‐dimethylellagic acid, were first identified in pomegranate fruits. Our results revealed the composition and abundance of primary and secondary metabolites in pomegranate fruit, which can lay the foundation for further elucidation of its nutritional and medicinal properties.

show abstract

Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet obese C57BL/6 mice

Goodarzi¹,

Tehrani²,

Panahi³

et al. 2023

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

Inhibitory effect of quercetin-3-O-α-rhamnoside, p-coumaric acid, phloridzin and 4-O-β-glucopyranosyl-cis-coumaric acid on rats liver microsomes cytochrome P450 enzyme activities

Cited by 4 publications

References 49 publications

Quercetin ameliorates hepatic fat accumulation in high-fat diet-induced obese mice via PPARs

Quercetin ameliorates hepatic fat accumulation in high-fat diet-induced obese mice via PPARs

Widely targeted metabolomics reveal the distribution of primary and secondary metabolites in pomegranate fruit

Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet obese C57BL/6 mice

Contact Info

Product

Resources

About