Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability

Kee, Ji‐Ye; Han, Yohan; Kim, Daeseung; Mun, Jeong‐Geon; Park, Jin Bong; Jeong, Mi-Young; Um, Jae‐Young; Hong, Seung‐Heon

doi:10.1016/j.phymed.2016.09.011

Cited by 102 publications

(55 citation statements)

References 38 publications

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“…Intrahepatic blood metastasis usually occurs in the early stages of HCC, resulting in the poor prognosis. We used the low-toxic dosage of quercetin (12.5, 25μmol/L) to treat SMMC-7721 cells, and cell monolayer scratching assay demonstrated that it could inhibit the migration, which was in accordance with the results of lung cancer and colon cancer studies [20,21]. Meanwhile, evenly distributed cells were observed within the middle of the scratches.…”

Section: Discussionsupporting

confidence: 69%

“…Quercetin can induce apoptosis, inhibit tumor growth and spread of brain, liver, and colon cells [18,19]. In addition, quercetin can suppress the invasiveness and metastasis of cancer cells [20,21]. The present study aimed to investigate the function of quercetin in HCC metastasis and its underlying mechanism.…”

Section: Discussionmentioning

confidence: 97%

“…In colorectal cancer, non-toxic dosage of quercetin could inhibit the EMT process by regulating the expression of E-cadherin, N-cadherin, β-catenin and snail, thus arresting the metastasis [21].…”

Section: Discussionmentioning

confidence: 99%

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Inhibitory effecT of quercetin on protein expression CtBP1 and migration of hepatocellular carcinoma cell SMMC-7721

Zhang

2018

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A B S T R A C TOur study aimed to investigate the potential role of quercetin in the migration of hepatocellular carcinoma cells, SMMC-7721, and its underlying mechanism. Cell monolayer scratching assay was performed to explore the role of quercetin in the migration ability of SMMC-7721 cells. Western Blot and immunofluorescence assay were conducted to detect the protein expression of transcriptional co-suppressor, CtBP1, and epithelial adhesion molecule, E-cadherin. The migration ability of SMMC-7721 cells was decreased by the addition of quercetin in a time and concentration dependent manner. Results of western blot and immunofluorescence assay demonstrated that quercetin inhibited the expression of CtBP1, while up-regulated the expression of E-cadherin. These findings suggest that quercetin contributed to the upregulation of E-cadherin through inhibition of CtBP1 expression. This in turn hinders the underlying EMT process, and finally prevents the invasiveness and metastasis of HCC cells. However, the mechanism how quercetin up-regulation CtBP1 in HCC cells still need to be elucidated.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 97%

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Inhibitory effecT of quercetin on protein expression CtBP1 and migration of hepatocellular carcinoma cell SMMC-7721

Zhang

2018

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“…Imperatorin, an active furanocoumarin component obtained from the root of Angelica dahurica, has been demonstrated to sensitize anoikis by downregulating Mcl-1 protein and upregulating Bax in lung cancer [82]. As a major dietary flavonoid, quercetin was reported to induce apoptosis through the MAPKs pathway, regulate EMT markers including E-, N-cadherin, β-catenin, and snail and modulate MMPs and TIMPs in colorectal cancer [83]. Curcumin, a compound derived from the rhizome of turmeric, was reported to inhibit the migratory and invasive ability of lung cancer cells through sensitizing anoikis, which was associated with downregulation of Bcl-2 [84].…”

Section: Anoikis Regulation Of Circulating Tumor Cellsmentioning

confidence: 99%

Recent Progress on the Molecular Mechanisms of Anti-invasive and Metastatic Chinese Medicines for Cancer Therapy

Wei¹,

Wang²,

Feng³

2017

Unique Aspects of Anti-Cancer Drug Development

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Despite of the recent advances in diagnostic and therapeutic approaches, cancer remains as the leading cause of death worldly with diverse causal factors regarding genes and environment. Invasion and metastasis, as one of the most important hallmarks for cancer, have restrained the successful clinical therapy and are the primary causes of death among cancer patients. So far, most chemotherapeutic drugs are not effective for metastatic cancer due to drug resistance and serious side effects. Therefore, it is urgently essential to develop more effective therapeutic methods. Owing to their diverse biological activities and low toxicity, naturally active compounds derived from Chinese medicines, as a complementary and alternative approach, are reported to promote the therapeutic index and provoked as an excellent source for candidates of anti-metastatic drugs. With the rapid development of molecular biology techniques, the molecular mechanisms of the effects of potential anti-invasive and metastatic Chinese medicines are gradually elucidated. This chapter reviews the potential anti-invasive and metastatic mechanisms of naturally active compounds from Chinese medicines, including suppression of EMT, proteases and cancer-induced angiogenesis, anoikis regulation of circulating tumor cells and regulation of miRNA-mediated gene expression, providing scientific evidence for clinically using Chinese medicines in the field of cancer therapy.

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“…Quercetin is a kind of natural polyhydroxy flavonoid that is found in various foods and plays a role in improving several diseases, such as diabetes, inflammation, and allergies (Hu, Lin, Zheng, & Cheung, ; Kee et al, ; Lin et al, ; Shen, Dang, et al, ; Shen, Lee, et al, ; Wang, Hu, et al, ; Wang, Hu, et al, ; Wang, Lam, et al, ; Wang, Lam, et al, ). Quercetin has a clear antagonistic effect on many kinds of malignant tumors (Kim et al, ) and can affect precancerous lesions of colon cancer by inhibiting the release of inflammatory factors (Miyamoto, Yasui, Ohigashi, Tanaka, & Murakami, ).…”

Section: Introductionmentioning

confidence: 99%

Alternating consumption of β‐glucan and quercetin reduces mortality in mice with colorectal cancer

et al. 2019

Food Science & Nutrition

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The current dietary recommendations for disease prevention and management are scarce and are not well supported. Beta‐glucan or quercetin in a diet can alleviate colorectal cancer (CRC) by regulating the gut microbiota and related genes, but the effects of alternating their consumption for routine ingestion during CRC occurrence remain unknown. This study investigated the effects of alternating the consumption of β‐glucan and quercetin for routine ingestion on CRC development in mice. The mortality rate, colonic length, inflammatory cytokines, gut microbiota, and colonic epithelial gene expression in healthy and CRC mice that consumed normal and alternate diets were compared and studied. The results showed that alternating the consumption of β‐glucan and quercetin (alternating among a β‐glucan diet, a normal diet and a normal diet that was supplemented with quercetin) alleviated colon damage and reduced the mortality rate in CRC mice, with a reduction in mortality of 12.5%. Alternating the consumption of β‐glucan and quercetin significantly decreased the TNF‐α level, increased the relative abundance of Parabacteroides, and downregulated three genes (Hmgcs2, Fabp2, and Gpt) that are associated with inflammation and cancer. Alternating the consumption of some bioactive compounds, such as β‐glucan and quercetin, in food can contribute to human health. This experiment provided some experimental evidence for the dietary recommendations for disease prevention and management.

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Inhibitory effect of quercetin on colorectal lung metastasis through inducing apoptosis, and suppression of metastatic ability

Cited by 102 publications

References 38 publications

Inhibitory effecT of quercetin on protein expression CtBP1 and migration of hepatocellular carcinoma cell SMMC-7721

Inhibitory effecT of quercetin on protein expression CtBP1 and migration of hepatocellular carcinoma cell SMMC-7721

Recent Progress on the Molecular Mechanisms of Anti-invasive and Metastatic Chinese Medicines for Cancer Therapy

Alternating consumption of β‐glucan and quercetin reduces mortality in mice with colorectal cancer

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