Inhibitory Effect of Tannin in Green Tea on the Proliferation of Mesangial Cells

Yokozawa, Takako; Oura, Hikokíchi; Hattori, Masao; Iwano, Masayuki; Dohi, Kazuhiro; Sakanaka, Senji; Kim, Mujo

doi:10.1159/000187570

Cited by 30 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, some plant foods have advantageous properties, apparently unrelated to macronutrient composition. For example, polyphenolics extracted from tea inhibited mesangial proliferation (19) and significantly prolonged renal survival in experimental models of glomerulosclerosis (20). Third, iron was an important factor in the progression of experimental nephropathy after the initial offending agent was removed (21).…”

mentioning

confidence: 99%

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

Facchini

Saylor

2003

Diabetes

View full text Add to dashboard Cite

Diabetic nephropathy has become the leading cause of uremia. Several lines of evidence suggest dietary factors other than protein intake have a substantial role in the progression of diabetic nephropathy to end-stage renal disease. The present investigation was initiated to evaluate whether a carbohydrate-restricted, low-ironavailable, polyphenol-enriched (CR-LIPE) diet may delay and improve the outcome of diabetic nephropathy to a greater extent than standard protein restriction. To this aim, 191 diabetic patients, all with type 2 diabetes, were randomized to either CR-LIPE or standard protein restriction and the following outcomes monitored: doubling of serum creatinine, cumulative incidence of endstage renal disease, and all cause mortality. Over a mean follow-up interval of 3.9 ؎ 1.8 years, serum creatinine concentration doubled in 19 patients on CR-LIPE (21%) and in 31 control subjects (39%) (P < 0.01). Renal replacement therapy or death occurred in 18 patients on CR-LIPE (20%) and in 31 control subjects (39%) (P < 0.01). These differences were independent from followup interval, sex, mean arterial blood pressure, HbA 1c , initial renal dysfunction, and angiotensin system inhibitor use. In conclusion, CR-LIPE was 40 -50% more effective than standard protein restriction in improving renal and overall survival rates.

show abstract

mentioning

confidence: 99%

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

Facchini

Saylor

2003

Diabetes

View full text Add to dashboard Cite

show abstract

“…Catechin analogues such as (-)-epicatechin 3-O-gallate (ECG) and EGCG, are known to have many physiological effects, such as antitumor (Morré et al, Suganuma et al, 1999) and radioprotective (Uchida et al, 1992) activities and to exert suppressive effects on renal et al, 1997). It is also apparent that ECG and EGCG inhibit the proliferation of mesangial cells (Yokozawa et al, 1993a(Yokozawa et al, , 1993b. In addition, EGCG inhibits the growth of OK cells, mostly via apoptosis (Miyamoto et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is no information about how the inhibition of NOX activity may induce apoptosis, although it is known that prolonged inhibition of the NOX form associated with tumor cell lines induces apoptosis. On the other hand, EGCG also has inhibitory effects on the proliferation of mouse (Yokozawa et al, 1993a) and human (Yokozawa et al, 1993b) mesangial cells. These cells, whose plasma membranes may contain NOX, are not tumor cell lines, but have been transformed to become proliferating cell lines, except for opossum kidney proximal tubular (OK) cells (Miyamoto et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

(-)-Epigallocatechin 3-O-gallate (EGCG) -induced apoptosis in normal rat kidney interstitial fibroblast (NRK-49F) cells

et al. 2008

View full text Add to dashboard Cite

“…These activities may be relevant to cancer prevention in experimental regimens where tea polyphenols are provided after a carcinogen. The ability of polyphenols to inhibit mitogenic signaling in vivo is supported by in vitro studies demonstrating antiproliferative effects of EGCG on numerous cell lines [24,[26][27][28][29][30][31][32][33][34][35]. However, mechanisms by which EGCG inhibits proliferation have not been…”

Section: Referencesmentioning

confidence: 99%

Effect on Green Tea Polyphenols on Breast Cancer Signaling.

Cobrinik¹

1999

View full text Add to dashboard Cite

Public reporting burden tor this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources qatherlnq and maintaining tn« data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information 'includinq suqqestions for reuucmg mis Ourden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302 and to the Office of Management and Budget,, Washington, DC 20503 '"«"** ina m me umce or AGENCY USE ONLY (Leave blank) REPORT DATE April 2000 REPORT TYPE AND DATES COVEREDFinal (1 A pr 98 3 0 AprJDO) TITLE AND SUBTITLE Effect of Green Tea Polyphenols on Breast Cancer Signaling AUTHOR(S)David Cobrinik, M.D., Ph.D. FUNDING NUMBERSDAMD17-98-1-8051 PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Columbia UniversityNew York, New York 10032dcl97@columbia.edu SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)U 12b. DISTRIBUTION CODEThis project aimed to define the effects of green tea polyphenols (GTPs) on cell signaling pathways and on mammary tumorigenesis in MMTV/c-neu transgenic mice. The studies showed that the major polyphenol in green tea, EGCG, did not impair erbB-2 tyrosine phosphorylation or EGF-dependent activation of MAP kinase in transformed or untransformed MCF10A cells, and that orally administered green tea or GTPs did not inhibit mammary tumorigenesis.Subsequent studies focused on the mechanism by which EGCG inhibits mammary epithelial cell cycle progression.EGCG inhibited S phase entry in epidermal growth factor (EGF)-stimulated MCF10A breast epithelial cells when provided in GO or mid Gl, but not when provided after the late Gl restriction point.EGCG induced p21 CIP1/WAF1/SDI \ inhibited cyclin Dl-associated pRB kinase activity, increased the association of p21 with cyclin Dl, and impaired pRB phosphorylation. EGCG induced p21 expression at the mRNA level.In addition, the ability of EGCG to induce p21 depended on the addition of EGF, indicating that EGCG synergizes with growth factor-dependent signals.While these findings provide a mechanism by which polyphenolic compounds may inhibit proliferation, their relevance to breast cancer chemoprevention remains unclear due to the lack of effect of tea polyphenols on tumorigenesis in MMTV/c-neu transgenic mice. SUBJECT TERMSBreast Cancer, green tea polyphenol, receptor tyrosine kinase, chemoprevention Foreword. SECURITY CLASSIFICATION OF REPORTIntroduction. Body 5Key Research Accomplishments 8Reportable Outcomes " 8Conclusions 8References 9 Appendix 10 INTRODUCTIONGreen tea polyphenols (GTPs) are potentially useful for delaying the onset of breast cancer, since they suppress tumorigenesis in rodents, they inhibit tumor cell proliferation in vitro and in vivo, and they are apparently safe natural products. However, since the mechanism through which GTPs suppress tumorigene...

show abstract

Inhibitory Effect of Tannin in Green Tea on the Proliferation of Mesangial Cells

Cited by 30 publications

References 12 publications

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

A Low-Iron-Available, Polyphenol-Enriched, Carbohydrate-Restricted Diet to Slow Progression of Diabetic Nephropathy

(-)-Epigallocatechin 3-O-gallate (EGCG) -induced apoptosis in normal rat kidney interstitial fibroblast (NRK-49F) cells

Effect on Green Tea Polyphenols on Breast Cancer Signaling.

Contact Info

Product

Resources

About