Inhibitory effect of topical antibiotics/antiseptics administration on bacterial growth in the open wound of the jawbone surgery: Randomized controlled, preliminary study

Abstract

Background/purpose TThe bone cavities after extirpation of cysts or tumor of the jawbone requires the insertion of gauze containing various antibiotics/antiseptics to minimize the risk of pain, bleeding, and surgical site infection (SSI). However, there have been few reports on the efficacy of topical administration of antibiotics/antiseptics to an open wound of the jawbone. To compare the inhibitory effects of topical povidone-iodine gel and tetracycline ointment on the jawbone wound bacterial growth after extirpation of cyst or tumor. Materials and methods This is a preliminary, randomized controlled, open-labeled trial. Eighteen patients were randomly assigned into two groups. In povidone-iodine (PI) group, gauze mixed with povidone-iodine gel was inserted into the bone cavity wound, and in tetracycline (TC) group gauze mixed with tetracycline ointment was inserted after extirpation of cyst or tumor of the jaw bone. In both groups, gauze was removed 48 h after surgery, and examined by bacterial culture and real-time polymerase chain reaction (PCR) using primers detecting total bacteria and MRSA. Results The topical application of tetracycline ointment was superior to that of povidone-iodine gel concerning inhibitory effects of total bacteria and methicillin-resistant Staphylococcus aureus (MRSA). Conclusion This preliminary study suggests that the insertion of gauze mixed with tetracycline ointment is recommended for bone wounds after extirpation of cyst or tumor of the oral cavity.

Combinatory effects of Dipterocarpus alatus twig emulgel: Wound-restoring, antibacterial, and anti-inflammatory activities against methicillin-resistant Staphylococcus aureus-infected mouse superficial wounds

“…Tetracycline is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria that is usually prescribed for bacterial skin infection [ 22 ]. A topical tetracycline ointment was superior to a povidone-iodine gel in terms of inhibitory effects towards MRSA [ 23 ]. Hence, D. alatus twig extract (with concentrations of 20 and 40 mg/g; D20 and D40) and tetracycline (Tetra) emulgel formulations were prepared for comparison in the current study.…”

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

“…Therefore, gas impregnated with Tec antibiotic ointment is generally used in open wounds of the jawbone. [ 148 ] In a report by Ranjbar‐Mohammadi et al, [ 149 ] CS/PLA nanofibers containing Tec antibiotic were prepared by electrospinning method. The results showed that long‐term controlled release of Tec was effective in treating some chronic infections.…”

Bacteriological Investigation and Drug Resistance Analysis of Chronic Refractory Wound Secretions

“…C hronic refractory wound refers to a wound that is difficult to heal for various reasons. 1,2 There are many types and complex causes, and it is not clearly defined currently. It is usually identified as a chronic wound that cannot be reduced by 10% to 15% per week or by 50% for more than 1 month.…”