Inhibitory effect of trehalose dimycolate (TDM) and its stereoisometric derivatives, trehalose dicorynomycolates (TDCMs), with low toxicity on lung metastasis of tumour cells in mice

Watanabe, Rikiya; Yoo, Yung Choon; Hata, Katsura; Mitobe, Manabu; Koike, Yuko; Nishizawa, Masatoyo; Garcia, Dulce M.; Nobuchi, Yoko; Imagawa, Hiroshi; Yamada, Hidetoshi; Azuma, Ichiro

doi:10.1016/s0264-410x(98)00367-3

Cited by 37 publications

(27 citation statements)

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“…11 and 12 Moreover, the absolute configuration of these two chiral centres is necessary for efficient recognition by T cells and the generation of an immune response by the host organism against pathogenic mycobacteria; 13 the same is also true for the antitumour properties of mycolic acid derivatives. 14 Mycolic acids are generally present as penta-arabinose tetramycolyl clusters bound to the cell wall or as non-bound species such as trehalose dimycolates (TDMs). These species exert a number of very important immunological effects.…”

Section: Openup (July 2007)mentioning

confidence: 99%

The first syntheses of single enantiomers of the major methoxymycolic acid of Mycobacterium tuberculosis

et al. 2007

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Section: Openup (July 2007)mentioning

confidence: 99%

The first syntheses of single enantiomers of the major methoxymycolic acid of Mycobacterium tuberculosis

et al. 2007

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“…An adjuvant modulates the immune response against the antigen enhancing its antigenicity and immunogenicity (21). Various adjuvant systems were tested for M. tuberculosis vaccination such as dimethyl dioctadecyl ammonium bromide, monophosphoryl lipid A (MPL), incomplete Freund adjuvant, and trehalose dicorynomycolate (TDM), a synthetic analogue of the mycobacterial trehalose dimycolate (24,31,50).…”

mentioning

confidence: 99%

Gamma Interferon and Monophosphoryl Lipid A-Trehalose Dicorynomycolate Are Efficient Adjuvants forMycobacterium tuberculosisMultivalent Acellular Vaccine

2005

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In this study, we examined the immunogenicity and protective efficacy of six immunodominant Mycobacterium tuberculosis recombinant antigens (85B, 38kDa, ESAT-6, CFP21, Mtb8.4, and 16kDa) in a multivalent vaccine preparation (6Ag). Gamma interferon (IFN-␥) and monophosphoryl lipid A-trehalose dicorynomycolate (Ribi) adjuvant systems were used separately or in combination for immunization with the recombinant antigens. Our results demonstrate that immunization of mice with Ribi emulsified antigens in the presence of IFN-␥ (Ribi؉6Ag؉IFN-␥) resulted after challenge with a virulent M. tuberculosis strain in a significant reduction in the CFU counts that was comparable to that achieved with the BCG vaccine (ϳ0.9-log protection). Antigen-specific immunoglobulin G (IgG) titers in the Ribi؉6Ag؉IFN-␥-immunized mice were lower than in mice immunized with Ribi؉6Ag and were oriented toward a Th1-type response, as confirmed by elevated IgG2a levels. In addition, splenocyte proliferation, IFN-␥ secretion, and NO production were significantly higher in splenocytes derived from Ribi؉6Ag؉IFN-␥-immunized mice, whereas IL-10 secretion was decreased. These findings confirm the induction of a strong cellular immunity in the vaccinated mice that correlates well with their enhanced resistance to M. tuberculosis. The adjuvant effect of IFN-␥ was dose dependent. A dose of 5 g of IFN-␥ per mouse per immunization gave optimal protection, whereas lower or higher amounts (0.5 or 50 g/ mouse) of IFN-␥ failed to enhance protection.

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“…However, most research are centered around the bio-activity of trehalose lipid molecules that exhibit biomedical properties such as antimicrobial, antiviral (Azuma et al, 1987;Watanabe et al, 1999;Shao, 2011) and antitumor activities (Sudo et al, 2000;. Due to their functions in cell membrane interactions they can act as therapeutic agents (Zaragoza et al, 2009;Shao, 2011) or have an impact on the pathogenesis of causative agents of infections, such as those caused by pathogenic M. tuberculosis, Corynebacterium diphteriae, and the opportunistic pathogens, Mycobacterium avium, Mycobacterium intracellulare, Nocardia asteroides, Corynebacterium matruchotii, and Corynebacterium xerosis (Kuyukina and Ivshina, 2010).…”

Section: Trehalose Lipid Estersmentioning

confidence: 99%

Microbiotechnology Based Surfactants and Their Applications

Rahman¹

2016

Frontiers Research Topics

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PublisherFrontiers in Microbiology About FrontiersFrontiers is more than just an open-access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers Journal SeriesThe Frontiers Journal Series is a multi-tier and interdisciplinary set of open-access, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers Journal Series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to QualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: researchtopics@frontiersin.org 2 February 2016 | Microbiotechnology Based Surfactants and Their Applications Frontiers in MicrobiologyBiosurfactants are structurally diverse group of bioactive molecules produced by a variety of microorganisms. They are secondary metabolites that accumulate at interfaces, reduce surface tension and form micellar aggregates. This research topic describes few novel microbial strains with a focus on increasing our understanding of genetics, physiology, regulation of biosurfactant production and their commercial potentials. A major stumbling block in the commercialization of b...

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Inhibitory effect of trehalose dimycolate (TDM) and its stereoisometric derivatives, trehalose dicorynomycolates (TDCMs), with low toxicity on lung metastasis of tumour cells in mice

Cited by 37 publications

References 34 publications

The first syntheses of single enantiomers of the major methoxymycolic acid of Mycobacterium tuberculosis

The first syntheses of single enantiomers of the major methoxymycolic acid of Mycobacterium tuberculosis

Gamma Interferon and Monophosphoryl Lipid A-Trehalose Dicorynomycolate Are Efficient Adjuvants forMycobacterium tuberculosisMultivalent Acellular Vaccine

Microbiotechnology Based Surfactants and Their Applications

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