Inhibitory Effect of Two Traditional Chinese Medicine Monomers, Berberine and Matrine, on the Quorum Sensing System of Antimicrobial-Resistant Escherichia coli

Sun, Tao; Li, Xiaodong; Hong, Juan; Liu, Can; Zhang, Xin-Luo; Zheng, Junhua; Xu, Youlong; Ou, Zheng-Yang; Zheng, Jing-Ling; Yu, Daojin

doi:10.3389/fmicb.2019.02584

Cited by 59 publications

(35 citation statements)

References 32 publications

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“…The CLSM, FESEM, and crystal violet staining results also showed that sanguinarine had a significant inhibitory effect on the P. rettgeri biofilm by blocking the expression and formation of biofilm substances, which led to the inactivation of P. rettgeri [ 68 ]. By changing the quorum sensing system, researchers observed that berberine inhibited biofilm formation in drug-resistant E. coli strains [ 86 ].…”

Section: Antibacterial Mechanisms Of Natural Alkaloidsmentioning

confidence: 99%

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

et al. 2021

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Alkaloids are nitrogen-containing heterocyclic compounds typically isolated from plants. They represent one of the most important types of natural products because of their large number and structural diversity and complexity. Based on their chemical core structures, alkaloids are classified as isoquinolines, quinolines, indoles, piperidine alkaloids, etc. In-depth analyses of alkaloids have revealed their antibacterial activities. To date, due to the widespread use of antibiotics, the problem of drug-resistant bacterial infections has been gradually increasing, which severely affects the clinical efficacy of antibacterial therapies and patient safety. Therefore, significant research efforts are focused on alkaloids because they represent a potentially new type of natural antibiotic with a wide antibacterial spectrum, rare adverse reactions, and a low tendency to produce drug resistance. Their main antibacterial mechanisms include inhibition of bacterial cell wall synthesis, change in cell membrane permeability, inhibition of bacterial metabolism, and inhibition of nucleic acid and protein synthesis. This article reviews recent reports about the chemical structures and the antibacterial activities and mechanisms of alkaloids. The purpose is to solve the problem of bacterial resistance and to provide a certain theoretical basis and research ideas for the development of new antibacterial drugs.

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Section: Antibacterial Mechanisms Of Natural Alkaloidsmentioning

confidence: 99%

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

et al. 2021

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“…Other alkaloids which can conduct these modulations include the phenothiazines [99][100][101]. Berberine (6), a well-established antimicrobial agent [102][103][104][105], inhibits biofilm formation of drug-resistant E. coli through the downregulation of quorum-sensing related genes [106]. It is available in good yield from several sources, including Berberis vulgaris L. (Berberidaceae), Coptis chinensis Franch.…”

Section: Antibiotic Drug Discoverymentioning

confidence: 99%

Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs

Daley¹,

Cordell

2021

Molecules

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An overview is presented of the well-established role of alkaloids in drug discovery, the application of more sustainable chemicals, and biological approaches, and the implementation of information systems to address the current challenges faced in meeting global disease needs. The necessity for a new international paradigm for natural product discovery and development for the treatment of multidrug resistant organisms, and rare and neglected tropical diseases in the era of the Fourth Industrial Revolution and the Quintuple Helix is discussed.

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“…Screening QS inhibitors from TCM resources has become a new strategy for the development of natural antibacterial agents ( Khider et al, 2019 ). Both Berberine and Matrine are able to inhibit biofilm formation of antimicrobial-resistant E. coli strains through downregulating the QS system, and Berberine is more effective than Matrine ( Sun et al, 2019 ).…”

Section: Inhibitory Mechanism Of Tcm On Antibiotic Resistancementioning

confidence: 99%

Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

Qiu

Hua

et al. 2020

Front. Microbiol.

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Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.

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Inhibitory Effect of Two Traditional Chinese Medicine Monomers, Berberine and Matrine, on the Quorum Sensing System of Antimicrobial-Resistant Escherichia coli

Cited by 59 publications

References 32 publications

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

Alkaloids in Contemporary Drug Discovery to Meet Global Disease Needs

Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

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