Inhibitory Effect of Vernonia amygdalina on Dimethylnitrosamine (DMN)-induced Liver Fibrosis in Rats

Usunobun, Usunomena; Paulinus, Okolie Ngozi; Gerald, Eze I.

doi:10.19070/2167-910x-1500030

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Mineral content of foods varied but generally substantial amounts of mineral and trace elements is available. The mineral element depends on the chemical composition of soil, cultural practices, time of planting and the amount of water available to the tuber plant (Osagie, 1992). FAO (1968;1972) reported the ash content of a sample of wet tissue of D. bulbifera as 1.0%.…”

Section: Effect Of Processing Methods On Proximate Composition Of Aermentioning

confidence: 99%

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Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

et al. 2017

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Section: Effect Of Processing Methods On Proximate Composition Of Aermentioning

confidence: 99%

“…Carbohydrate content constitutes the major dry matter component of all the dried D. bulbifera samples as same as in other yam varieties (Oyenuga, 1968;Ihekeronye and Ngoddy, 1985;Osagie, 1992).…”

Section: Effect Of Processing Methods On Proximate Composition Of Aermentioning

confidence: 99%

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

et al. 2017

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“…Bile produced by the liver also emulsifies fats from food, making it easier for lipase action during digestion (Partel et al, 2019). The hepatic portal vein connects the liver to the heart where it receives oxygenated blood from the heart and in turn supply blood with glucose, vitamins, proteins and nutrients necessary to the heart (Usunomena et al, 2015;Sani et al, 2020;Uchenna et al, 2021). The numerous and multifaceted functions of the liver make it a target for many toxins and pathogens which often results in hepatic diseases such as hepatitis, hepatoma, hepatomegaly, fibrosis, hepatocellular carcinoma, hepatosteatosis and hepatobiliary disorders (Akpanyung et al, 2019;Akharaiyu and Okafor, 2021).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Plant Extracts in Non-Human Models: The Toxicants Solvents and Diseased Models-A Review

Dongsogo,

Larbie,

Idrissu

et al. 2023

Am. J. Multidis. Res. Innov.

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The search for an ideal hepatic regenerative agent has led to the modelling of several forms of liver disorders. This involves the usage of various substances in in-vitro and in-vivo systems that are injurious to the human liver in in-vitro and in-vivo systems and then challenged with plants parts extracted with organic and inorganic solvents. Reported view works on hepatotoxicity have been focused on the plant species, this review therefore focused on the toxicants, the solvents for extraction and models used in inducing the hepatotoxicity. Google search, Elsevier and PubMed databases were searched for primary articles from 2005-2022 on hepatotoxicity. In all, 206 articles were retrieved, of which 46 were rejected and 165 were included for the analysis. Authors reported 55 toxicants used in inducing 10 in-vitro and in-vitro models and challenged with 94 different medicinal plants species extracted using 11 different organic and inorganic solvents. Comparatively, tetrachloromethane (CCL4) was the most frequent toxicant 55 of 94 (58.5%) reported plant species while ethanol 25 (45.5%) was the most frequently used solvent for extracting plant phytoconstituents. For the models used in inducing hepatotoxicity, Wistar albino rats 46 of the 55 (83.6%) reported toxicants was the most predominant. The liver is prone to many available toxicants however, phytohepatoregeneration is possible with many medicinal plants which can easily be extracted with common solvents.

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The Role of Cymbopogon Citratus Extract in Protecting the Liver Against Injurious Effect of Dimethylnitrosamine in Rats

Sarg¹

2015

IJCDA

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Background: N-Nitrosodimethylamine (NDMA) is a potent hepatotoxin that induces fibrosis of the liver. Cymbopogon citratus, a plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. Aim of the work: This work is aimed to study the protective effect of Cymbopogon citratus ethanolic leaf extract against hepatic injury and fibrosis induced by repeated intermittent administration of Dimethylnitrosamine (DMN) in rats. Materials and methods: A total of 30 rats divided into 3 groups were used. Group 1 served as control, Group 2 was given intraperitoneal injection with DMA at a concentration of 10mg/kg body weight on three consecutive days of each week over a period of three weeks. Group 3 was given DMA at a concentration of 10mg/kg body weight on three consecutive days of each week over a period of three weeks and 100 mg/kg body weight of Cymbopogon citratus ethanolic aqueous leaf extract 5 hours after administration of DMN. Results: It was found that DMN produces histopathological changes of the liver; including signs of severe hepatic injury. The cytoplasm of most hepatocytes appeared vacuolated with pyknotic and karyolytic nuclei, congested blood vessels and focal necrotic areas with marked increase of the collagen fibers deposition around the blood vessels. Ultrastructural changes showed Pyknotic nuclei, vacuolated cytoplasm and reduction or complete loss of cristae in the mitochondria. These were reversed by simultaneous treatment with Cymbopogon citratus. In conclusion: The results of this present study indicated that aqueous leaf extracts of Cymbopogon citratus has an antihepatotoxic action against DMN induced hepatic oxidative damage in rats which might be ascribed to its antioxidant and free radical scavenging property.

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Inhibitory Effect of Vernonia amygdalina on Dimethylnitrosamine (DMN)-induced Liver Fibrosis in Rats

Abstract: Materials and Methods Collection, Identification and Preparation of plant materialsFresh leaves of Vernonia amygdalina were purchased from a local market in Benin City, Edo state, Nigeria. The leaves were identified by Dr.

Cited by 6 publications

References 40 publications

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Physicochemical Properties of Processed Aerial Yam (Dioscorea bulbifera) and Sensory Properties of Paste (Amala) Prepared with Cassava Flour

Hepatoprotective Activity of Plant Extracts in Non-Human Models: The Toxicants Solvents and Diseased Models-A Review

The Role of Cymbopogon Citratus Extract in Protecting the Liver Against Injurious Effect of Dimethylnitrosamine in Rats

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