Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms

Chang, Han Lin; Chang, Fang Rong; Chen, Jin Shan; Wang, Hui Po; Wu, Yuan-Hua; Wang, Chien Chiao; Wu, Yang Chang; Hwang, Tsong‐Long

doi:10.1016/j.ejphar.2008.02.041

Cited by 26 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, in a couple of studies, Chang et al [11,36] have reported that a clerodane diterpenoid from Formosan P. longifolia var. pendula significantly inhibited the generation of superoxide anion and the release of elastase in activated human neutrophils in a concentration-dependent fashion, thereby demonstrating that the stem bark of P. longifolia possesses anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Gene Expression by Polyalthia longifolia in Postmenopausal Women with Coronary Artery Disease: An In Vitro Study

Mittal

Mahajan

Vijayvergiya

et al. 2009

J. of Cardiovasc. Trans. Res.

View full text Add to dashboard Cite

Chronic underlying inflammation is involved in the pathophysiology of coronary artery disease (CAD). Polyalthia longifolia var. pendula bark extract (PLE) is known to exhibit anti-inflammatory activity and has high content of phytosteroids. Since phytosteroids mimic estrogen structurally, we postulated that PLE may provide protection in postmenopausal women against CAD. Thus the effect of PLE has been explored on expression of estrogen receptors (ERalpha and ERbeta) and inflammatory inducible nitric oxide synthase (iNOS) genes in vitro in peripheral blood mononuclear cells (PBMCs) obtained from postmenopausal women. A total of 20 postmenopausal women were included in the present study. Group I (N = 10) included women with angiographically proven CAD, and group II (N = 10) is composed of equal number of age-matched healthy postmenopausal females as controls. Significantly low levels of serum 17-beta estradiol were observed in subjects of group I as compared to group II (p < 0.01). A marked increase in L: -citrulline levels (p > 0.05) and significantly augmented levels of reactive nitrogen intermediates (p < 0.05) were observed in group I subjects. PLE significantly attenuated PMA-induced expression of both ERalpha and ERbeta receptors and inflammatory iNOS gene in vitro in a dose- and time-dependent manner and had an additive effect on these genes when compared with tamoxifen. Ours is the first report to demonstrate that PLE contains certain bioactive principles, which possess anti-inflammatory and estrogenic properties, and thereby hold the promise to be screened for their anti-atherogenic potential in experimental animals to favorably alter several other markers of cardiovascular risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Modulation of Gene Expression by Polyalthia longifolia in Postmenopausal Women with Coronary Artery Disease: An In Vitro Study

Mittal

Mahajan

Vijayvergiya

et al. 2009

J. of Cardiovasc. Trans. Res.

View full text Add to dashboard Cite

show abstract

“…They play important roles in the host defense against microorganisms and in the pathogenesis of various diseases (Malech and Gallin 1987;Witko-Sarsat et al 2000;Chang et al 2008). In response to diverse stimuli, activated neutrophils secrete the superoxide anion (O 2 -) and a series of cytotoxins (Malech and Gallin 1987;Roos et al 2003;Chang et al 2008). It is essential to control respiratory burst and degranulation in physiological conditions while potentiating these functions in infected tissues and organs (Hsieh et al 2007;Chang et al 2008).…”

Section: Anti-inflammatory Activitymentioning

confidence: 98%

“…In response to diverse stimuli, activated neutrophils secrete the superoxide anion (O 2 -) and a series of cytotoxins (Malech and Gallin 1987;Roos et al 2003;Chang et al 2008). It is essential to control respiratory burst and degranulation in physiological conditions while potentiating these functions in infected tissues and organs (Hsieh et al 2007;Chang et al 2008). Since there are only a few agents used to modulate neutrophil pro-inflammatory responses, the research and development of new generation anti-inflammatory agents continues.…”

Section: Anti-inflammatory Activitymentioning

confidence: 98%

“…Human neutrophils are active phagocytes that are crucial components of immunity (Hsieh et al 2007;Chang et al 2008). They play important roles in the host defense against microorganisms and in the pathogenesis of various diseases (Malech and Gallin 1987;Witko-Sarsat et al 2000;Chang et al 2008).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants

Hsieh

Hsu

Lai

et al. 2009

World J Microbiol Biotechnol

Self Cite

View full text Add to dashboard Cite

The endophytic extracts from 19 endophytes, isolated from 13 species of Taiwanese plants, were evaluated for biological activity, including cytotoxicity, anti-platelet aggregation, and anti-inflammatory activity. The extracts of 12 endophytes exhibited inhibitory effects on collageninduced platelet aggregation with IC 50 values of 19.85-87.64 lg/ml. Four strains, Rahnella aquatilis, Pantoea agglomerans, Rhodotorula sp., and Penicillium paxilli, also showed inhibitory effects on thrombin-induced platelet aggregation with IC 50 values of 42.80-61.54 lg/ml. Additionally 12 extracts of endophytes exhibited cytotoxicities with IC 50 values of 0.12-19.83 lg/ml. However, eight extracts revealed inhibitory effects on superoxide anion generation induced by fMLP (N-formyl-L-methionyl-L-leucyl-L-phenylalanine) in human neutrophils. The extract of Rahnella aquatilis showed anti-platelet aggregation activity, and bioassay-directed fractionation led to the isolation of six compounds, including one isoalloxazine: lumichrome (1); two isoflavones: genistein (2) and daidzein (3); two cyclic peptides: cyclo-Pro-Val (4) and cyclo-Pro-Phe (5); and one benzenoid: methyl 2,4,5-trimethoxybenzoate (6). These results indicated that endophytes from Taiwanese herbal plants could be useful sources for research and development of bioactive lead compounds from nature.

show abstract

Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives

Yang

Kuo

Hwang

et al. 2011

Bioorganic & Medicinal Chemistry

View full text Add to dashboard Cite

Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms

Cited by 26 publications

References 32 publications

Modulation of Gene Expression by Polyalthia longifolia in Postmenopausal Women with Coronary Artery Disease: An In Vitro Study

Modulation of Gene Expression by Polyalthia longifolia in Postmenopausal Women with Coronary Artery Disease: An In Vitro Study

Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants

Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives

Contact Info

Product

Resources

About