Inhibitory effects of 2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate on allergic inflammatory responses in rat basophilic leukemia cells

Caffeic acid methyl ester inhibits mast cell activation through the suppresion of MAPKs and NF-κB signaling in RBL-2H3 cells

“…NF-κB is the major transcription factor for the expression of a variety of pro-inflammatory mediators such as iNOS, IL-1β, and TNF-α and the expression of adhesion molecules [ 40 , 41 ]. The aberrant activation of NF-κB has been widely demonstrated to be associated with various pathologic conditions including autoimmune diseases [ 42 ].…”

3,4,5‑Trihydroxycinnamic acid suppresses phorbol‑12‑myristate‑13‑acetate and A23187‑induced mast cell activation in RBL‑2H3 cells

“…The addition of PMA and A21387 to mast cells results in the phosphorylation of MAPK cascade including p38, ERK1/2, and JNK pathways and subsequent expression of cytokines (39,40). It has been reported that coumarin derivative attenuated PMA/A21378-induced allergic response by suppressing ERK1/2 signaling pathway in RBL-2H3 cells (41) and CAME, a caffeic acid derivate, has been reported to suppress allergic response by inhibiting JNK activation in HMC-1 human mast cells (6). In addition, bisdemmethoxycoumarin has been reported to inhibit all three MAPKs and suppress allergic response in PMA/A21378-induced HMC-1 human mast cells (7).…”

Flavoring agent dihydrocoumarin alleviates IgE-mediated mast cell activation and allergic inflammation

“…29 Because of its critical roles in mediating immune signaling, the MAPK cascade including p38, ERK, and JNK pathways represents appropriate targets to study inflammatory responses. 30,31 To further examine the effects of DHC treatment on the signaling cascade, the inhibitory activities of DHC against the MAPK pathways were assessed. Previously, the traditional Chinese medicinal product berberine was shown to suppress MCmediated allergic responses via the regulation of FcεRI-…”