Inhibitory effects of 2-substituted-1-naphthol derivatives on cyclooxygenase I and II

Kongkathip, Boonsong; Sangma, Chak; Kirtikara, Kanyawim; Luangkamin, Suwaporn; Hasitapan, Komkrit; Jongkon, Nipa; Hannongbua, Supa; Kongkathip, Ngampong

doi:10.1016/j.bmc.2004.12.054

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…Missing hydrogens and Kollman partial charges were added before performing docking. The grid size was set to 90×90×90 points with 0.25 Å spacing centered on the COX-2 (Kongkathip et al, 2005). The default parameter setting was used to perform the docking calculations and only docking with the lowest binding energies were selected for further investigations.…”

Section: Molecular Dockingmentioning

confidence: 99%

Antioxidant Activity of Piper Caninum and Cyclooxygenase-2 Inhibition by Methoxylated Flavones

Nadri

Naser

Zulkifli

et al. 2015

Afr J Tradit Complement Altern Med

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Background: The crude extracts and pure compounds isolated from Piper caninum was studied for their bioactivities. Material and method: The present study was carried out with the following aims: (1) to quantify the total phenolic content and free radical scavenging activities of the crude extracts by Folin-Ciocalteu and 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay. (2) to determine the cyclooxygenase-2 inhibition activities of selected isolated compounds as assessed by molecular docking and in vitro cyclooxygenase-2 inhibition assay. Results: Methanolic extracts of Piper caninum exhibited the highest total phenolic content and free radical scavenging activities. All the pure compounds possessed significant cyclooxygenase-2 inhibition at physiological concentrations. Conclusion: Based on our findings of the molecular docking and in vitro study, we therefore suggest that Piper caninum methoxylated flavones are potent inhibitors of cyclooxygenase-2 at physiological concentrations.

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Section: Molecular Dockingmentioning

confidence: 99%

Antioxidant Activity of Piper Caninum and Cyclooxygenase-2 Inhibition by Methoxylated Flavones

Nadri

Naser

Zulkifli

et al. 2015

Afr J Tradit Complement Altern Med

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“…(Insanu et al 2014). These compounds, according to another research on different plant, showed an inhibitory effect on COX-2 (Kaur et al, 2009;Shin et al, 2006;Kongkathip et al, 2005;Oku and Ishiguro, 2002). It is strongly believed that it cure the BPH (Indrawati and Razimin, 2013 ) but the molecular mechanism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Apoptotic Potency of Bawang Dayak(Elutherine americana) Bulb Extract as Inhibitor of BPH through Computational Studies

Sutapa

Utomo²,

Widodo

et al. 2019

Pakistan Journal of Scientific & Industrial Research

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Benign Prostatic Hyperplasia (BPH) is indicated by hyperproliferation of prostate epithelial and stromal cells. Bawang Dayak (Elutherine americana) is an Indonesian endemic plant which is used as herbal medicine for BPH. This study aimed to reveal the potency of Bawang Dayak bulbs extracts as an inhibitor agent of BPH cells. The research was conducted based on in silica approach. The 3D structure of active compound and protein target were studied and analyzed molecular interaction, calculated binding affinity, and pharmacophore, visualized biomolecules, and analyzed biological activity of each active compound. They are naphthalene, naphthoquinone, and anthraquinone. All active compounds have a higher binding affinity to COX-2. It has the highest binding affinity value around -8.7 Kcal/mol. Anthraquinone has an ability as anti-inflammatory and apoptosis agonist, which blocks the COX-2 active site, so, the Bcl- 2 would be inactivated and apoptosis can occur immediately. Keywords:

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“…Naphthols and their methyl ethers also possess useful biologically activities. They show inhibitory activity with preferential inhibition on cyclooxygenase I and II [11,12].…”

Section: Introductionmentioning

confidence: 99%

Rearrangements of Cycloalkenyl Aryl Ethers

et al. 2016

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Rearrangement reactions of cycloalkenyl phenol and naphthyl ethers and the acid-catalyzed cyclization of the resulting product were investigated. Claisen rearrangement afforded 2-substituted phenol and naphthol derivatives. Combined Claisen and Cope rearrangement resulted in the formation of 4-substituted phenol and naphthol derivatives. In the case of cycloocthylphenyl ether the consecutive Claisen and Cope rearrangements were followed by an alkyl migration. The mechanism of this novel rearrangement reaction is also discussed.

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Inhibitory effects of 2-substituted-1-naphthol derivatives on cyclooxygenase I and II

Cited by 9 publications

References 25 publications

Antioxidant Activity of Piper Caninum and Cyclooxygenase-2 Inhibition by Methoxylated Flavones

Antioxidant Activity of Piper Caninum and Cyclooxygenase-2 Inhibition by Methoxylated Flavones

Apoptotic Potency of Bawang Dayak(Elutherine americana) Bulb Extract as Inhibitor of BPH through Computational Studies

Rearrangements of Cycloalkenyl Aryl Ethers

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