Inhibitory Effects of Acylated Acyclic Sesquiterpene Oligoglycosides from the Pericarps of Sapindus rarak on Tumor Necrosis Factor-.ALPHA.-Induced Cytotoxicity

Abstract

Four new acylated acyclic sesquiterpene oligoglycosides (1-4) were isolated from the pericarps of Sapindus rarak DC. together with four known acyclic sesquiterpene oligoglycosides, mukuroziosides Ia (5), Ib (6), IIa (7), and IIb (8). Their structures were elucidated on the basis of chemical and physicochemical evidence. These newly isolated compounds (1-4) were found to show inhibitory effects on tumor necrosis factor-a-induced cytotoxicity in L929 cells at concentrations of 30-100 mM.

Aromatase Inhibitory Activity of Geranylated Coumarins, Mammeasins C and D, Isolated from the Flowers of <i>Mammea siamensis</i>

“…The following instruments were used to obtain physical data: UV spectra, UV-1600 spectrometer (Shimadzu Co., Kyoto, Japan); IR spectra, FTIR-8100 spectrometer (Shimadzu Co.); EI-MS and HR-EI-MS, JMS-GCMATE mass spectrometer (JEOL Ltd., Tokyo, Japan); 1 H-NMR spectra, JNM-ECA500 (500 MHz), and JNM-ECS400 (400 MHz) spectrometers (JEOL); 13 C-NMR spectra, JNM-ECA500 (125 MHz), and JNM-ECS400 (100 MHz) spectrometers (JEOL Ltd.) with tetramethylsilane as an internal standard; HPLC detector, SPD-10Avp UV-VIS detector (Shimadzu Co.); HPLC column, Cosmosil 5C 18 -MS-II (Nacalai Tesque, Inc., Kyoto, Japan), 4.6×250 mm i.d. and 20×250 mm i.d.…”

“…[1][2][3][4][5][6][7][8][9][10] Several coumarins, [1][2][3][4][5][6][7] xanthones, 8,9) triterpenoids, 10) and steroids 10) have been isolated from the flowers, 1,2,6,7,10) seeds, 3,9) twigs, 4,8) and bark 5) of this plant. In the course of our characterization studies on bioactive constituents in Thai natural medicine, 1,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] we reported that the methanol extract of the flowers of M. siamensis and its coumarin constituents showed inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.…”

“…In the course of our characterization studies on bioactive constituents in Thai natural medicine, 1,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] we reported that the methanol extract of the flowers of M. siamensis and its coumarin constituents showed inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 cells. 1) Further studies revealed that the methanol extract inhibited enzymatic activity against aromatase.…”

Iridoid and Acyclic Monoterpene Glycosides, Kankanosides L, M, N, O, and P from Cistanche tubulosa

“…On the basis of above-mentioned concept, we investigated protective constituents from naturally occurring products on TNF-a-induced cell death in L929 cells, a TNF-a-sensitive cell line. 25) Previously, we have reported that several constituents from Piper chaba, [26][27][28][29] Boesenbergia rotunda, 30,31) Punica granatum, 32) Helichrysum arenarium, [33][34][35] and Sapindus rarak, [36][37][38] were found to show inhibitory effects of TNF-a-induced cytotoxicity in L929 cells. Since the phenylethanoid constituents of C. tubulosa (e.g.…”

Structures of Two New Phenolic Glycosides, Kaempferiaosides A and B, and Hepatoprotective Constituents from the Rhizomes of <i>Kaempferia parviflora</i>

“…18) By a previous chemical study on K. parviflora, presence of several methoxyflavones and related phenolic constituents have been revealed. 2,5,6,[10][11][12][13][14][15]17,[19][20][21][22] During the course of our characterization studies on Thai natural medicines, [23][24][25][26][27][28][29][30][31][32] two new phenolic glycosides named kaempferiaosides A (1) and B (2) were isolated from the rhizomes of K. parviflora together with 24 known compounds. This paper deals with the structure elucidation of 1 and 2, as well as hepatoprotective effect of the constituents from the rhizomes of K. parviflora on D-galactosamine (D-GalN)-induced cytotoxicity in primary cultured mouse hepatocytes.…”