Inhibitory Effects of Angelicae Dahuricae Radix Extract on COPD induced by Cigarette Smoke Condensate and Lipopolysaccharide in Mice

Kwak, Ho-Geun; Lim, Hyun

doi:10.7783/kjmcs.2011.19.5.380

Korean Journal of Medicinal Crop Science

2011

DOI: 10.7783/kjmcs.2011.19.5.380

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Inhibitory Effects of Angelicae Dahuricae Radix Extract on COPD induced by Cigarette Smoke Condensate and Lipopolysaccharide in Mice

Ho-Geun Kwak¹,

Hyun Lim²

Abstract: : This study was carried out to investigate the inhibitory effect of Angelicae Dahuricae Radix (ADR) extract on chronic obstructive pulmonary disease (COPD) induced by cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) in mice. COPD was induced by intratracheal instillation of LPS and CSC 5 times for 12 days; this increased airway hyperresoponsiveness (

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Cited by 3 publications

References 29 publications

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Plantas medicinais utilizadas no tratamento de doenças respiratórias crônicas: Período de 2010 a 2020

Mourão

Silva

Gomes

et al. 2021

RSD

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A Doença Pulmonar Obstrutiva Crônica (DPOC) é considerada um conjunto de doenças respiratórias como a bronquite crônica e enfisema pulmonar que são caracterizadas principalmente por inflamação progressiva e redução do fluxo de ar nas vias aéreas. Se desenvolvi sobretudo pelo tabagismo ativo ou passivo, inalação de gases ou partículas tóxicas. Seu tratamento consiste na redução de sintomas, progressão e melhorar a vida de seus portadores. Porém, este tratamento é limitado e apresenta efeitos colaterais com o uso prolongado, o que desencadeia a necessidade de busca de novas terapias. O uso de plantas medicinas, no tratamento de doenças pulmonares vem crescendo a cada dia e demostrando ser uma opção viável e eficaz. Seu uso é possível, devido a presença de metabolitos secundários, que apresentam atividades farmacológicas como anti-inflamatória e antioxidante. O objetivo deste trabalho foi realizar uma revisão bibliográfica das plantas medicinais e compostos ativos utilizados como forma de tratamento para DPOC no período de janeiro 2010 a setembro 2020. Identificou-se 79 artigos, dentre eles as pesquisas envolveram plantas medicinais, compostos isolados de plantas medicinais e fitoterápicos utilizados na medicina tradicional chinesa. Em geral, a pesquisa mostrou que os metabolitos secundários identificados apresentaram atividade anti-inflamatória e antioxidante que em sua maioria, pertencem a classe dos flavonoides, alcaloides, saponinas, cumarinas e terpenos.

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Plantas medicinais utilizadas no tratamento de doenças respiratórias crônicas: Período de 2010 a 2020

Mourão

Silva

Gomes

et al. 2021

RSD

View full text Add to dashboard Cite

show abstract

Antiasthmatic Effects on Scutellaria baicalensis Georgi Extracts Against Airway Inflammation and Hyperresponsiveness Induced by Diesel Exhaust Particles with Ovalbumin Sensitization

Lim

Kim²

2012

Korean Journal of Medicinal Crop Science

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: The feature of asthma are airway inflammation (AI), reversible airway obstruction, and an increased sensitivity to bronchoconstricting agents, elevated airway hyperresponsiveness (AHR), excess production of Th2 cytokines, and eosinophil accumulation in the lungs. This study was performed to investigate if oral administration of Scutellaria baicalensis Georgi water extracts (SBG) have the antiasthmatic potential for the treatment of asthma. Asthmatic HI and AHR were induced by systemic sensitization to ovalbumin (OVA) with intratracheal instillation with 0.1 ㎎/mL of diesel exhaust particles (DEP) suspension once a week for 10 weeks in BALB/c mice. SBG was orally administered with the concentraion of 200 ㎎/㎏ 5 days a week for 10 weeks. Long-term SBG treatment suppressed the eosinophil infiltration into airways from blood, the asthmatic AI and AHR by attenuating the production of cytokine IL-4, IL-5 and IL-13, histamine and OVA-specific IgE. Our data suggest that SBG has inhibitory effects on AI and AHR in a mouse model of asthma, may act as a potential Th2 cytokine antagonist, and may have a therapeutic effect on allergic asthma.

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Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

Kwak

Lim²

2013

Korean Journal of Medicinal Crop Science

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: Traditionally, Ligustrum lucidum fruits (LL) is one of the well-known oriental herb used in the treatment of skin and lung inflammation. This study investigated anti-inflammatory effects of LL in the pathogenesis of acute pulmonary inflammation in mice. Acute pulmonary inflammation was induced by intratracheal instillation of cigarette smoke condensate (CSC) and lipopolysaccharide (LPS) 5 times within 12 days in mice. LL extract was administered orally at a dose of 50 or 200 ㎎/㎏. Administration of LPS and CSC significantly elevated airway hyperresponsiveness (AHR) to mice, and increased in the levels of inflammatory cells and mediators in mice. However, the LL extract significantly reduced the elevated AHR, and the increase of neutrophils, CD4 + /CD3+ cells and CD8 + /CD3 + cells, along with reducing the expression of TNF-α, IL-6, and MIP-2. Moreover, the LL extract alleviated the infiltration of inflammatory cells in expanded airway walls histologically. These results indicate that the LL extract has an inhibitory effects on acute pulmonary inflammation and AHR in murine model, and plays a crucial role as a immunomodulator which possess anti-inflammatory property.

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Inhibitory Effects of Angelicae Dahuricae Radix Extract on COPD induced by Cigarette Smoke Condensate and Lipopolysaccharide in Mice

Cited by 3 publications

References 29 publications

Plantas medicinais utilizadas no tratamento de doenças respiratórias crônicas: Período de 2010 a 2020

Plantas medicinais utilizadas no tratamento de doenças respiratórias crônicas: Período de 2010 a 2020

Antiasthmatic Effects on Scutellaria baicalensis Georgi Extracts Against Airway Inflammation and Hyperresponsiveness Induced by Diesel Exhaust Particles with Ovalbumin Sensitization

Ligustrum lucidum Fruits Extract Inhibits Acute Pulmonary Inflammation in Mice

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