Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells

Kanda, Tomomasa; Akiyama, Hiroshi; Yanagida, Akio; Tanabe, Masayuki; Goda, Yukihiro; Toyoda, Masatake; Teshima, Reiko; Saitō, Yukio

doi:10.1271/bbb.62.1284

Cited by 152 publications

(117 citation statements)

References 31 publications

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“…Since glucose release from food sources is the main factor affecting post-prandial hyperglycaemia, retardation of the digestion of starch by key gastrointestinal enzymes can be of benefit to diabetic patients (Puls and Keup, 1973). Also, various dietary components such as polyphenols in tea (Matsuo et al, 2000), soybean (Takasugi et al, 2002), and apple (Kanda et al, 1998), fla-vonoids (Corvazier and Maclouf, 1985), and polyunsaturated fatty acids (Yamada et al, 1996) suppress the release of mediators from basophils or mast cells, which in turn prevent the pathogenesis of type 1 allergy. A type I allergic reaction involves the production of allergen-specific IgE and release of a chemical mediator such as histamine or leukotrienes (LT) from basophils or mast cells.…”

Section: Introductionmentioning

confidence: 99%

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Hossain

Tsujiyama

Takasugi

et al. 2008

FSTR

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To seek out a cheap source of dietary polyphenols and antioxidants along with anti-amylase and antiglucosidase activities, ethanol extracts of eleven cheap Bangladeshi fruits were investigated. The extracts were also examined for anti-allergic activity using rat peritoneal exudate cells exposed to the calcium ionophore A23187. Phyllanthus emblica (emblic myrobalan) had the highest total polyphenol content (339 mg gallic acid equivalent (GAE)/g), followed by Syzygium cumini (Indian blackberry; 192.3 mg GAE/g), and Aegle marmelos (wood apple; 53.7 mg GAE/g). P. emblica, and S. cumini also exhibited the most potent DPPH radical scavenging activity, with an IC 50 of 2.1 and 8.6 μg/mL respectively. These extracts also showed promising reducing powers with P. emblica having the greatest such activity (optical density (O.D.) 1.66), followed by S. cumini (O.D. 1.34), at a concentration of 0.2 mg/mL. The extracts of Artocarpus heterophyllus (jackfruit) and S. cumini showed promising chelating activities. At a concentration of 1 mg/ mL, Dillenia indica (chalta) showed the highest inhibition of α-amylase activity (60%), and A. marmelos, D. indica, P. emblica, Spondias dulcis (hog-plum) & S. cumini completely inhibited α-glucosidase activity (100%). Apart from A. heterophyllus, D. indica and Phyllanthus acidus (star-gooseberry), all other extracts inhibited the release of histamine from the peritoneal exudate cells, with S. cumini having the strongest effect. These fruits therefore have activities beneficial to physiological health. Keywords: antioxidant, anti-amylase, anti-glucosidase, anti-allergy, antihistamine release, fruits, polyphenol *To whom correspondence should be addressed. Email: aoshima@yamaguchi-u.ac.jp IntroductionFruits are major sources of health promoting agents. Of these agents, antioxidants are most important because they inhibit the initiation of lipid peroxidation, which is related to aging and the pathogenesis of diseases such as cardiovascular disorders, cancer, inflammation, and brain dysfunction (Ames, 1983;Shon et al., 2004). Various epidemiological studies have suggested that consumption of fruit and vegetables is associated with reduced risk of cardiovascular diseases and cancers (Kris-Etherton et al., 2002), neurodegenerative diseases such as Parkinson's and Alzheimer's diseases (Di Matteo and Esposito, 2003), as well as with inflammation and aging (Ames et al., 1993).Natural products are reportedly beneficial to physiological health. Various flavonoids and non-flavonoids have been reported as showing radical scavenging activity (Sawa et al., 1999): flavone, and flavonoids inhibit α-amylase and α-glucosidase activities (Havsteen, 1983;Kim et al., 2000); polyphenols have anti-hyperglycemic effects (Hossain et al., 2002;Hanamura et al., 2006), and inhibit the development of diabetes (Zunimo et al., 2007). Since glucose release from food sources is the main factor affecting post-prandial hyperglycaemia, retardation of the digestion of starch by key gastrointestinal enzymes can be of benefit to...

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Section: Introductionmentioning

confidence: 99%

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Hossain

Tsujiyama

Takasugi

et al. 2008

FSTR

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“…So, effect of hyaluronidase inhibition is used to evaluate anti-allergic activity. At present, research on the phytochemical compositions and anti-allergic activities of food materials are progressing (Kaneda et al, 1998;Yamamoto et al, 2004). Hyaluronidase inhibitory activities of extracts from berries were determined.…”

Section: Hyaluronidase Inhibitory Activitymentioning

confidence: 99%

Physicochemical and Health Promoting Properties of Everbearing Strawberry Cultivar, ‘Dekoruju’ Berries

Nagai¹,

Kai²,

Tanoue³

et al. 2018

JAS

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Overall appearance on everbearing strawberry cultivar, 'Dekoruju' berries were observed. Berries were glossy and colors of skins and pulps were favorable (red-fleshed). An eating quality was good and berries had a favorable balance of sweetness and sourness because of higher sugar-acid ration (14.6) of berries. Berries were foods rich in vitamin B 1 (0.35±0.02 mg/100 g FW) and phenol compounds (80.4±0.6 mg/100 g FW) such as anthocyanins and flavonoids. Extracts prepared from berries, especially in 100% concentration, almost completely inhibited linoleic acid peroxidation under the condition tested. These showed extremely high scavenging activities against specially superoxide anion (92.2±2.16%) and DPPH (> 100%) radicals in comparison with all commercially available natural or synthetic antioxidants tested. These also exhibited the foremost inhibitory activities against not only ACE (62.7±5.1%) but also hyaluronidase (67.6±3.5%), suggesting beneficial effects on anti-hypertension, anti-allergy, and anti-inflammatory. The present study indicated that fresh 'Dekoruju' berries may be considered as good sources of natural antioxidants such as phenol compounds (anthocyanins and flavonoids), and may contribute to maintain and promote health and to help protect body against chronic diseases and an allergy disease.

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“…Herbs containing polyphenols often elicit their wound-healing activities by such mechanisms as antibacterial, anti-inlammatory, and proregenerative activities. The antibacterial and anti-inlammatory properties of polyphenols will also prevent swelling and itching of the wounds by inhibiting the release and activities of allergic mediators such as histamine and serotonin [57,58].…”

Section: Health Beneits Of Polyphenolsmentioning

confidence: 99%

Wound Care: Traditional African Medicine Approach

Builders¹,

Builders²

2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Wound care represents a major health burden in "frica. The types and causes of wounds in "frica are numerousɤ however, the interventions to these injuries are easily accessed in hospitals in the urban cities, while in most rural communities, the primary source of interventions is traditional medicine (TMɮ. In recent times, there are incidences of preferences to the use of TM in the management of especially challenging wounds even when conventional interventions are available. In some "frican communities, there are incidences of quasi integration of conventional and traditional "frican medicine (T"Mɮ in wound care. In the typical traditional "frican approach to wound care, diverse practices such as the use of herbal medicine, divination, and other physical interventions are common. There appears to be a favorable future for wound management using T"M with the increasing popularity due to various airmative reasons other than poverty. The recognition, patronage, and uses of T"M for wound care as an alternative or complimentary to the conventional approach is expected to continue, hence, the need for the diferent regional governments in consonance with the WHO to promote the standardization, regulation, and other factors that will assure the safety and eicacy of the various practices and products of T"M.

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Inhibitory Effects of Apple Polyphenol on Induced Histamine Release from RBL-2H3 Cells and Rat Mast Cells

Cited by 152 publications

References 31 publications

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Total Phenolic Content, Antioxidative, Anti-amylase, Anti-glucosidase, and Antihistamine Release Activities of Bangladeshi Fruits

Physicochemical and Health Promoting Properties of Everbearing Strawberry Cultivar, ‘Dekoruju’ Berries

Wound Care: Traditional African Medicine Approach

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