Inhibitory effects of chickpea and Tribulus terrestris on lipase, α-amylase and α-glucosidase

Ercan, Pınar; El, Sedef Nehir

doi:10.1016/j.foodchem.2016.03.012

Cited by 109 publications

(65 citation statements)

References 28 publications

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“…The gross saponins of T. terrestris (GSTT) showed inhibitory activity against α -glucosidase. In addition, it showed the inhibition activities of a postprandial increase in blood glucose and improvement in insulin dependent diabetes symptoms [68]. Animal experiments indicated that GSTT significantly reduced the postprandial blood glucose levels by intragastric administration of sucrose in normal rats and type 2 diabetic rats but did not affect the postprandial blood glucose levels of the rats with intragastric administration of glucose [69].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Zhu

Meng

et al. 2017

Chemistry Central Journal

133

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“…F I G U R E 2 Inhibitory effects of Allium mongolicum extracts from methanol and aqueous on the activities of α-glucosidase (a), pancreatic lipase (b), and Angiotensin I-converting enzyme (c) obesity(Ramirez et al, 2016). Thus, inhibition on the activity of pancreatic lipase is a valuable method for the treatment of overweight and obesity(Ercan & El, 2016). The lipase inhibitory effects of samples were measured by monitoring the hydrolysis of p-nitrophenyl laurate (pNP laurate), which releases the yellow chromogen p-nitrophenol(pNP).…”

mentioning

confidence: 99%

Phenolic compounds and bioactivity evaluation of aqueous and methanol extracts ofAllium mongolicumRegel

Wang

Zhang

et al. 2019

Food Science & Nutrition

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Allium mongolicum Regel (AM), widely distributed in western China, is a traditional Mongolian medicine herb. Two different solvents as water and methanol were used to extract AM, and their antioxidant capacity and inhibitory effects against key enzymes related to metabolic syndrome were assessed. The antioxidant capacity was evaluated through the assay of radical scavenging ability on DPPH and ABTS and reducing power assays. In addition, the total phenolic content and total flavonoids content were quantificated and analyzed. Aqueous extract, having higher phenolic content (10.20 mg GAE/g DW) and flavonoid content (4.02 mg QE/g DW), showed better antioxidant and inhibitory effects against lipase and angiotensin‐converting enzyme (ACE); as for α‐glucosidase, the extract made by methanol showed better ability. In general, the aqueous extract of A. mongolicum Regel has the potential to be used as a functional food or nutraceutical in prevention and treatment of obesity and hypertension due to the high antioxidant and sound inhibitory potential against vital enzymes relevant to obesity and hypertension.

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“…Pancreatic lipase (PL) is a key enzyme for hydrolysing dietary triglycerides in the small intestine and rapidly releasing 2‐monoglyceride and free fatty acids (Ercan & El, ). It was reported that white tea and green tea could effectively inhibit the activity of lipase and the inhibition of white tea was more efficient comparatively (Gondoin et al ., ).…”

Section: Inhibitory Effects Of the Tea Or Tea Components On The Enzymesmentioning

confidence: 99%

Stop for tea? Enzyme inhibitors from tea – what good are they?

Zhao

et al. 2016

Int J of Food Sci Tech

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Summary Tea possesses many bioactive components including polyphenols, theanine and caffeine. Inhibitory effect of these components on the various enzymes involved in some chronic diseases was reviewed in this study. Many studies revealed that anti‐obesity of tea was mainly ascribed to the polyphenols which could inhibit the activity of the enzymes related to diet metabolism such as α‐amylase, α‐glucosidase and lipase. Inhibitory effect of catechins and caffeine against β‐ and γ‐secretase, acetylcholinesterase, protein kinase C and histone deacetylase might be responsible for the prevention from nervous system diseases. Cytochrome P450 enzymes, cytosolic sulfotransferases, cyclooxygenase‐2 and phosphoinositide‐3‐kinase could be efficiently suppressed by catechins, which would decrease the risk of cancer initiation and proliferation; theanine could lower the activity of some anticarcinogen‐activated enzymes and alleviate the adverse effect of cancer cure. Catechins and caffeine exhibited significant inhibition against the matrix metalloproteinases, histidine decarboxylase and many kinases related to inflammation. Thus, catechins, theanine and caffeine might be employed as inhibitors of the enzymes associated with these chronic diseases.

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Inhibitory effects of chickpea and Tribulus terrestris on lipase, α-amylase and α-glucosidase

Cited by 109 publications

References 28 publications

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Phenolic compounds and bioactivity evaluation of aqueous and methanol extracts ofAllium mongolicumRegel

Stop for tea? Enzyme inhibitors from tea – what good are they?

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