Inhibitory effects of Chrysanthemum species extracts on formation of advanced glycation end products

Naito, Michitaka; Saeki, Hisaaki; Hamano, Miyuki

doi:10.1016/j.foodchem.2009.03.042

Cited by 76 publications

(56 citation statements)

References 30 publications

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“…The anti-glycation capacity of numerous medicinal herbs and dietary plants was comparable with [59], or even stronger than that of aminoguanidine [42,60,[61][62][63]. Several studies have demonstrated that the anti-glycation activity correlates significantly with the phenolic content of the tested plant extracts [5,50,59,64,65].…”

Section: Polyphenolsmentioning

confidence: 94%

“…Moreover, a number of plantderived products have been shown to possess hypoglycemic, hypolipidemic as well as antioxidant properties [40]. Some important compounds such as phenolics [41,42], oligoand polysaccharides [43,44], carotenoids [45,46], unsaturated fatty acids [45,46] and many others have been reported to possess anti-glycating activity. Thus, the daily consumption of dietary components, mainly from plant sources which have an antioxidant effect, is considered to be of potential benefit for prevention of diabetes and diabetic complications [47].…”

Section: Therapeutic Agentsmentioning

confidence: 99%

“…In 2009 Gugliucci et al demonstrated that caffeic acid in Ilex paraguariensis extracts inhibits the generation of fluorescent AGEs in in vitro experiments [65]. Moreover, extracts from two Chrysanthemum species (C. morifolium R. and C. indicum L.) demonstrated marked inhibition of the formation of AGEs and CML in in vitro model systems [42]. The plant extracts inhibited the formation of total AGEs after one week of incubation in BSA/glucose and BSA/fructose systems.…”

Section: Cinnamic Acids and Derivativesmentioning

confidence: 99%

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Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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Section: Polyphenolsmentioning

confidence: 94%

Section: Therapeutic Agentsmentioning

confidence: 99%

Section: Cinnamic Acids and Derivativesmentioning

confidence: 99%

See 1 more Smart Citation

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

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“…Inhibition of Amadori products formation, α-dicarbonyl compounds and glycation of amino group [51] Astragalus membranaceus (Milk Vetch) Astragaloside IV (AGS-IV) Lowering glucose level and aldose reductase pathway increasing plasma insulin levels and glutathione peroxidase activity [67] Camellia sinesis (Green and Black tea) Epicatechins, theaflavins, EGCG Trapping of α-dicarbonyl compounds [54,97] Chrysanthemum morifolium and C. indicum (Chrysanthemum) Chlorogenic acid, flavonoid glucoside, apigenin, caffeic acid, luteolin, kaempferol Free radical and metal scavenging [49] Cinnamomum zeylacnicum (Cinnamon) Cinnamtannin B1, catechin, epicatechin, procyanidin B2…”

Section: Plantmentioning

confidence: 99%

“…Tsuji-Natio et al reported that Chrysanthemum morifolium Ramat. (Asteraceae) prevented the formation of fluorescent AGEs more effectively than Chrysanthemum indicum L. due to a higher content of flavonoids and other active components in its extract [49]. It is evident that different organs of the same plant produce different secondary metabolites.…”

Section: Plantmentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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Variation in Polyphenolic Profiles, Antioxidant and Antimicrobial Activity of Different Achillea Species as Natural Sources of Antiglycative Compounds

Afshari

Rahimmalek

Miroliaei

2018

Chemistry & Biodiversity

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A comparative study was carried out on the methanolic extracts from six Achillea species and the examined polyphenols from these plants on the formation of advanced glycation end-products (AGE) in vitro. A. pachycephala which was richer in flavonoids (15 mg quercetin/g W) and phenolics (111.10 mg tannic acid/g DW) with substantial antioxidant activity (IC = 365.5 μg/ml) presented strong anti-AGE properties. Chlorogenic acid, luteolin, quercetin and caffeic acid were identified as the major polyphenols in the extracts by HPLC. In general, polyphenolic content follows the order of A. pachycephalla > A. nobilis > A. filipendulina > A. santolina > A. aucheri > A. millefolium. Most extracts exhibited marked anti-AGE ability in the bovine serum albumin (BSA)/methylglyoxal (MG) system, though A. pachycephala showed the highest potential. The formation of AGEs was assessed by monitoring the production of fluorescent products and circular dichroism (CD) spectroscopy. Diminution in free radical production (assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays) is discussed as potential mechanism for delay or reduced AGE. The results demonstrate the antiglycative, antioxidant and antimicrobial potential of Achillea species which can be attributed to polyphenols content and the effectiveness on generation of AGEs, thus Achillea species can be considered as natural sources for slowing down glycation related diseases.

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Inhibitory effects of Chrysanthemum species extracts on formation of advanced glycation end products

Cited by 76 publications

References 30 publications

Plant-Derived Agents with Anti-Glycation Activity

Plant-Derived Agents with Anti-Glycation Activity

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

Variation in Polyphenolic Profiles, Antioxidant and Antimicrobial Activity of Different Achillea Species as Natural Sources of Antiglycative Compounds

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